The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Transcriptional coactivator/pterin dehydratase
".
FunFam 1: Pterin-4-alpha-carbinolamine dehydratase 2
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 11 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
39 |
P61457 (/IPI)
P61457 (/IPI)
P61457 (/IPI)
P61457 (/IPI)
P61457 (/IPI)
P61457 (/IPI)
P61457 (/IPI)
P61457 (/IPI)
P61457 (/IPI)
P61457 (/IPI)
(29 more) |
|
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
36 |
P61459 (/IDA)
P61459 (/IDA)
P61459 (/IDA)
P61459 (/IDA)
P61459 (/IDA)
P61459 (/IDA)
P61459 (/IDA)
P61459 (/IDA)
P61459 (/IDA)
P61459 (/IDA)
(26 more) |
|
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
36 |
P61457 (/TAS)
P61457 (/TAS)
P61457 (/TAS)
P61457 (/TAS)
P61457 (/TAS)
P61457 (/TAS)
P61457 (/TAS)
P61457 (/TAS)
P61457 (/TAS)
P61457 (/TAS)
(26 more) |
|
4-alpha-hydroxytetrahydrobiopterin dehydratase activity GO:0008124
Catalysis of the reaction: (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H(2)O.
|
36 |
P61459 (/IDA)
P61459 (/IDA)
P61459 (/IDA)
P61459 (/IDA)
P61459 (/IDA)
P61459 (/IDA)
P61459 (/IDA)
P61459 (/IDA)
P61459 (/IDA)
P61459 (/IDA)
(26 more) |
|
4-alpha-hydroxytetrahydrobiopterin dehydratase activity GO:0008124
Catalysis of the reaction: (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H(2)O.
|
36 |
P61459 (/TAS)
P61459 (/TAS)
P61459 (/TAS)
P61459 (/TAS)
P61459 (/TAS)
P61459 (/TAS)
P61459 (/TAS)
P61459 (/TAS)
P61459 (/TAS)
P61459 (/TAS)
(26 more) |
|
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
36 |
P61457 (/IPI)
P61457 (/IPI)
P61457 (/IPI)
P61457 (/IPI)
P61457 (/IPI)
P61457 (/IPI)
P61457 (/IPI)
P61457 (/IPI)
P61457 (/IPI)
P61457 (/IPI)
(26 more) |
|
Phenylalanine 4-monooxygenase activity GO:0004505
Catalysis of the reaction: L-phenylalanine + tetrahydrobiopterin + O2 = L-tyrosine + 4-alpha-hydroxytetrahydrobiopterin.
|
2 | P61458 (/IDA) Q9CZL5 (/IDA) |
|
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
1 | P61458 (/ISO) |
|
4-alpha-hydroxytetrahydrobiopterin dehydratase activity GO:0008124
Catalysis of the reaction: (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H(2)O.
|
1 | O42658 (/ISM) |
|
4-alpha-hydroxytetrahydrobiopterin dehydratase activity GO:0008124
Catalysis of the reaction: (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H(2)O.
|
1 | P61458 (/ISO) |
|
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
1 | P61458 (/ISO) |
There are 11 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
37 |
P61459 (/IDA)
P61459 (/IDA)
P61459 (/IDA)
P61459 (/IDA)
P61459 (/IDA)
P61459 (/IDA)
P61459 (/IDA)
P61459 (/IDA)
P61459 (/IDA)
P61459 (/IDA)
(27 more) |
|
L-phenylalanine metabolic process GO:0006558
The chemical reactions and pathways involving L-phenylalanine, the L-enantiomer of 2-amino-3-phenylpropanoic acid, i.e. (2S)-2-amino-3-phenylpropanoic acid.
|
36 |
P61459 (/IDA)
P61459 (/IDA)
P61459 (/IDA)
P61459 (/IDA)
P61459 (/IDA)
P61459 (/IDA)
P61459 (/IDA)
P61459 (/IDA)
P61459 (/IDA)
P61459 (/IDA)
(26 more) |
|
L-phenylalanine metabolic process GO:0006558
The chemical reactions and pathways involving L-phenylalanine, the L-enantiomer of 2-amino-3-phenylpropanoic acid, i.e. (2S)-2-amino-3-phenylpropanoic acid.
|
36 |
P61459 (/TAS)
P61459 (/TAS)
P61459 (/TAS)
P61459 (/TAS)
P61459 (/TAS)
P61459 (/TAS)
P61459 (/TAS)
P61459 (/TAS)
P61459 (/TAS)
P61459 (/TAS)
(26 more) |
|
L-phenylalanine catabolic process GO:0006559
The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid.
|
36 |
P61457 (/TAS)
P61457 (/TAS)
P61457 (/TAS)
P61457 (/TAS)
P61457 (/TAS)
P61457 (/TAS)
P61457 (/TAS)
P61457 (/TAS)
P61457 (/TAS)
P61457 (/TAS)
(26 more) |
|
Regulation of protein homodimerization activity GO:0043496
Any process that modulates the frequency, rate or extent of protein homodimerization, interacting selectively with an identical protein to form a homodimer.
|
36 |
P61459 (/IDA)
P61459 (/IDA)
P61459 (/IDA)
P61459 (/IDA)
P61459 (/IDA)
P61459 (/IDA)
P61459 (/IDA)
P61459 (/IDA)
P61459 (/IDA)
P61459 (/IDA)
(26 more) |
|
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
2 | P61458 (/ISO) Q9CZL5 (/ISO) |
|
Protein homotetramerization GO:0051289
The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.
|
2 | P61458 (/IPI) Q9CZL5 (/IPI) |
|
Protein heterooligomerization GO:0051291
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers that are not all identical. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
|
2 | P61458 (/IPI) Q9CZL5 (/IPI) |
|
L-phenylalanine metabolic process GO:0006558
The chemical reactions and pathways involving L-phenylalanine, the L-enantiomer of 2-amino-3-phenylpropanoic acid, i.e. (2S)-2-amino-3-phenylpropanoic acid.
|
1 | P61458 (/ISO) |
|
Ascospore formation GO:0030437
The process in which cells that are products of meiosis acquire the specialized features of ascospores. Ascospores are generally found in clusters of four or eight spores within a single mother cell, the ascus, and are characteristic of the ascomycete fungi (phylum Ascomycota).
|
1 | O42658 (/IMP) |
|
Regulation of protein homodimerization activity GO:0043496
Any process that modulates the frequency, rate or extent of protein homodimerization, interacting selectively with an identical protein to form a homodimer.
|
1 | P61458 (/ISO) |
There are 13 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
38 |
P61458 (/IPI)
P61459 (/IPI)
P61459 (/IPI)
P61459 (/IPI)
P61459 (/IPI)
P61459 (/IPI)
P61459 (/IPI)
P61459 (/IPI)
P61459 (/IPI)
P61459 (/IPI)
(28 more) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
36 |
P61457 (/IDA)
P61457 (/IDA)
P61457 (/IDA)
P61457 (/IDA)
P61457 (/IDA)
P61457 (/IDA)
P61457 (/IDA)
P61457 (/IDA)
P61457 (/IDA)
P61457 (/IDA)
(26 more) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
36 |
P61457 (/IDA)
P61457 (/IDA)
P61457 (/IDA)
P61457 (/IDA)
P61457 (/IDA)
P61457 (/IDA)
P61457 (/IDA)
P61457 (/IDA)
P61457 (/IDA)
P61457 (/IDA)
(26 more) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
36 |
P61457 (/IDA)
P61457 (/IDA)
P61457 (/IDA)
P61457 (/IDA)
P61457 (/IDA)
P61457 (/IDA)
P61457 (/IDA)
P61457 (/IDA)
P61457 (/IDA)
P61457 (/IDA)
(26 more) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
36 |
P61457 (/TAS)
P61457 (/TAS)
P61457 (/TAS)
P61457 (/TAS)
P61457 (/TAS)
P61457 (/TAS)
P61457 (/TAS)
P61457 (/TAS)
P61457 (/TAS)
P61457 (/TAS)
(26 more) |
|
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
36 |
P61457 (/HDA)
P61457 (/HDA)
P61457 (/HDA)
P61457 (/HDA)
P61457 (/HDA)
P61457 (/HDA)
P61457 (/HDA)
P61457 (/HDA)
P61457 (/HDA)
P61457 (/HDA)
(26 more) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | O42658 (/HDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | P61458 (/ISO) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
1 | P61458 (/ISO) |
|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
1 | Q9CZL5 (/HDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | O42658 (/HDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | P61458 (/ISO) |
|
Ascospore-type prospore GO:0042764
An immature spore undergoing development. The spore usually consists of nucleic acid, prospore membrane(s) that encase the nucleic acid, and ultimately a cell wall that covers the membrane(s). This type of spore is observed in ascospore-forming fungi.
|
1 | O42658 (/IDA) |