The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: 40S ribosomal protein S21

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 9 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Ribosome binding GO:0043022
Interacting selectively and non-covalently with any part of a ribosome.
97 B3MLA8 (/ISS) B3MLA8 (/ISS) B3MLA8 (/ISS) B3MLA8 (/ISS) B3MLA8 (/ISS) B3MLA8 (/ISS) B3NA78 (/ISS) B3NA78 (/ISS) B3NA78 (/ISS) B3NA78 (/ISS)
(87 more)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
43 P63220 (/HDA) P63220 (/HDA) P63220 (/HDA) P63220 (/HDA) P63220 (/HDA) P63220 (/HDA) P63220 (/HDA) P63220 (/HDA) P63220 (/HDA) P63220 (/HDA)
(33 more)
Protein N-terminus binding GO:0047485
Interacting selectively and non-covalently with a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
43 P63220 (/IPI) P63220 (/IPI) P63220 (/IPI) P63220 (/IPI) P63220 (/IPI) P63220 (/IPI) P63220 (/IPI) P63220 (/IPI) P63220 (/IPI) P63220 (/IPI)
(33 more)
Structural constituent of ribosome GO:0003735
The action of a molecule that contributes to the structural integrity of the ribosome.
15 P0C0V8 (/IDA) P0C0V8 (/IDA) P0C0V8 (/IDA) P0C0V8 (/IDA) P0C0V8 (/IDA) P0C0V8 (/IDA) P0C0V8 (/IDA) P0C0V8 (/IDA) Q3E754 (/IDA) Q3E754 (/IDA)
(5 more)
Structural constituent of ribosome GO:0003735
The action of a molecule that contributes to the structural integrity of the ribosome.
5 O76927 (/HDA) O76927 (/HDA) O76927 (/HDA) O76927 (/HDA) O76927 (/HDA)
Structural constituent of ribosome GO:0003735
The action of a molecule that contributes to the structural integrity of the ribosome.
5 O76927 (/TAS) O76927 (/TAS) O76927 (/TAS) O76927 (/TAS) O76927 (/TAS)
Ribosome binding GO:0043022
Interacting selectively and non-covalently with any part of a ribosome.
5 O76927 (/IPI) O76927 (/IPI) O76927 (/IPI) O76927 (/IPI) O76927 (/IPI)
Protein N-terminus binding GO:0047485
Interacting selectively and non-covalently with a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
3 Q9CQR2 (/ISO) Q9CQR2 (/ISO) Q9CQR2 (/ISO)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 P05764 (/IPI)

There are 18 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasmic translation GO:0002181
The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein.
95 P05765 (/ISS) P63221 (/ISS) P63221 (/ISS) P63221 (/ISS) P63221 (/ISS) P63221 (/ISS) P63221 (/ISS) P63221 (/ISS) P63221 (/ISS) P63221 (/ISS)
(85 more)
Regulation of cell population proliferation GO:0042127
Any process that modulates the frequency, rate or extent of cell proliferation.
50 B3MLA8 (/ISS) B3MLA8 (/ISS) B3MLA8 (/ISS) B3MLA8 (/ISS) B3MLA8 (/ISS) B3MLA8 (/ISS) B3NA78 (/ISS) B3NA78 (/ISS) B3NA78 (/ISS) B3NA78 (/ISS)
(40 more)
Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184
The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins.
43 P63220 (/TAS) P63220 (/TAS) P63220 (/TAS) P63220 (/TAS) P63220 (/TAS) P63220 (/TAS) P63220 (/TAS) P63220 (/TAS) P63220 (/TAS) P63220 (/TAS)
(33 more)
Cytoplasmic translation GO:0002181
The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein.
43 P63220 (/IDA) P63220 (/IDA) P63220 (/IDA) P63220 (/IDA) P63220 (/IDA) P63220 (/IDA) P63220 (/IDA) P63220 (/IDA) P63220 (/IDA) P63220 (/IDA)
(33 more)
Translation GO:0006412
The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.
43 P63220 (/IC) P63220 (/IC) P63220 (/IC) P63220 (/IC) P63220 (/IC) P63220 (/IC) P63220 (/IC) P63220 (/IC) P63220 (/IC) P63220 (/IC)
(33 more)
Translation GO:0006412
The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.
43 P63220 (/NAS) P63220 (/NAS) P63220 (/NAS) P63220 (/NAS) P63220 (/NAS) P63220 (/NAS) P63220 (/NAS) P63220 (/NAS) P63220 (/NAS) P63220 (/NAS)
(33 more)
Translational initiation GO:0006413
The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.
43 P63220 (/TAS) P63220 (/TAS) P63220 (/TAS) P63220 (/TAS) P63220 (/TAS) P63220 (/TAS) P63220 (/TAS) P63220 (/TAS) P63220 (/TAS) P63220 (/TAS)
(33 more)
SRP-dependent cotranslational protein targeting to membrane GO:0006614
The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane.
43 P63220 (/TAS) P63220 (/TAS) P63220 (/TAS) P63220 (/TAS) P63220 (/TAS) P63220 (/TAS) P63220 (/TAS) P63220 (/TAS) P63220 (/TAS) P63220 (/TAS)
(33 more)
Viral transcription GO:0019083
The process by which a viral genome, or part of a viral genome, is transcribed within the host cell.
43 P63220 (/TAS) P63220 (/TAS) P63220 (/TAS) P63220 (/TAS) P63220 (/TAS) P63220 (/TAS) P63220 (/TAS) P63220 (/TAS) P63220 (/TAS) P63220 (/TAS)
(33 more)
Cytoplasmic translation GO:0002181
The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein.
20 O76927 (/IC) O76927 (/IC) O76927 (/IC) O76927 (/IC) O76927 (/IC) P0C0V8 (/IC) P0C0V8 (/IC) P0C0V8 (/IC) P0C0V8 (/IC) P0C0V8 (/IC)
(10 more)
Endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) GO:0000447
Endonucleolytic cleavage between the SSU-rRNA and the 5.8S rRNA of an rRNA molecule originally produced as a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript.
15 P0C0V8 (/IMP) P0C0V8 (/IMP) P0C0V8 (/IMP) P0C0V8 (/IMP) P0C0V8 (/IMP) P0C0V8 (/IMP) P0C0V8 (/IMP) P0C0V8 (/IMP) Q3E754 (/IMP) Q3E754 (/IMP)
(5 more)
Endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) GO:0000461
Endonucleolytic cleavage at the 3'-end of the SSU-rRNA from an originally tricistronic rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript, to produce the mature end of the SSU-rRNA.
15 P0C0V8 (/IMP) P0C0V8 (/IMP) P0C0V8 (/IMP) P0C0V8 (/IMP) P0C0V8 (/IMP) P0C0V8 (/IMP) P0C0V8 (/IMP) P0C0V8 (/IMP) Q3E754 (/IMP) Q3E754 (/IMP)
(5 more)
Cytoplasmic translation GO:0002181
The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein.
5 O76927 (/TAS) O76927 (/TAS) O76927 (/TAS) O76927 (/TAS) O76927 (/TAS)
Regulation of cell population proliferation GO:0042127
Any process that modulates the frequency, rate or extent of cell proliferation.
5 O76927 (/IMP) O76927 (/IMP) O76927 (/IMP) O76927 (/IMP) O76927 (/IMP)
Lymph gland development GO:0048542
The process whose specific outcome is the progression of the lymph gland over time, from its formation to the mature structure. The lymph gland is one of the sites of hemocyte differentiation. It consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages.
5 O76927 (/IMP) O76927 (/IMP) O76927 (/IMP) O76927 (/IMP) O76927 (/IMP)
Cytoplasmic translation GO:0002181
The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein.
3 Q9CQR2 (/ISO) Q9CQR2 (/ISO) Q9CQR2 (/ISO)
Cytoplasmic translational elongation GO:0002182
The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis in the cytoplasm.
1 P05764 (/NAS)
Ribosomal small subunit biogenesis GO:0042274
A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis.
1 P05764 (/IMP)

There are 20 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosolic small ribosomal subunit GO:0022627
The small subunit of a ribosome located in the cytosol.
102 P05765 (/IDA) P0C0V8 (/IDA) P0C0V8 (/IDA) P0C0V8 (/IDA) P0C0V8 (/IDA) P0C0V8 (/IDA) P0C0V8 (/IDA) P0C0V8 (/IDA) P0C0V8 (/IDA) P63220 (/IDA)
(92 more)
Polysomal ribosome GO:0042788
A ribosome bound to mRNA that forms part of a polysome.
95 P05765 (/ISS) P63221 (/ISS) P63221 (/ISS) P63221 (/ISS) P63221 (/ISS) P63221 (/ISS) P63221 (/ISS) P63221 (/ISS) P63221 (/ISS) P63221 (/ISS)
(85 more)
Cytosolic small ribosomal subunit GO:0022627
The small subunit of a ribosome located in the cytosol.
51 Q32PB8 (/ISS) Q32PB8 (/ISS) Q32PB8 (/ISS) Q32PB8 (/ISS) Q32PB8 (/ISS) Q32PB8 (/ISS) Q32PB8 (/ISS) Q32PB8 (/ISS) Q32PB8 (/ISS) Q32PB8 (/ISS)
(41 more)
Ribosome GO:0005840
An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins.
50 B3MLA8 (/ISS) B3MLA8 (/ISS) B3MLA8 (/ISS) B3MLA8 (/ISS) B3MLA8 (/ISS) B3MLA8 (/ISS) B3NA78 (/ISS) B3NA78 (/ISS) B3NA78 (/ISS) B3NA78 (/ISS)
(40 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
43 P63220 (/TAS) P63220 (/TAS) P63220 (/TAS) P63220 (/TAS) P63220 (/TAS) P63220 (/TAS) P63220 (/TAS) P63220 (/TAS) P63220 (/TAS) P63220 (/TAS)
(33 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
43 P63220 (/TAS) P63220 (/TAS) P63220 (/TAS) P63220 (/TAS) P63220 (/TAS) P63220 (/TAS) P63220 (/TAS) P63220 (/TAS) P63220 (/TAS) P63220 (/TAS)
(33 more)
Small ribosomal subunit GO:0015935
The smaller of the two subunits of a ribosome.
43 P63220 (/HDA) P63220 (/HDA) P63220 (/HDA) P63220 (/HDA) P63220 (/HDA) P63220 (/HDA) P63220 (/HDA) P63220 (/HDA) P63220 (/HDA) P63220 (/HDA)
(33 more)
Cytosolic small ribosomal subunit GO:0022627
The small subunit of a ribosome located in the cytosol.
43 P63220 (/HDA) P63220 (/HDA) P63220 (/HDA) P63220 (/HDA) P63220 (/HDA) P63220 (/HDA) P63220 (/HDA) P63220 (/HDA) P63220 (/HDA) P63220 (/HDA)
(33 more)
Cytosolic small ribosomal subunit GO:0022627
The small subunit of a ribosome located in the cytosol.
43 P63220 (/NAS) P63220 (/NAS) P63220 (/NAS) P63220 (/NAS) P63220 (/NAS) P63220 (/NAS) P63220 (/NAS) P63220 (/NAS) P63220 (/NAS) P63220 (/NAS)
(33 more)
Polysomal ribosome GO:0042788
A ribosome bound to mRNA that forms part of a polysome.
43 P63220 (/IDA) P63220 (/IDA) P63220 (/IDA) P63220 (/IDA) P63220 (/IDA) P63220 (/IDA) P63220 (/IDA) P63220 (/IDA) P63220 (/IDA) P63220 (/IDA)
(33 more)
Cytoplasmic side of rough endoplasmic reticulum membrane GO:0098556
The side (leaflet) of the rough endoplasmic reticulum membrane that faces the cytoplasm.
43 P63221 (/IDA) P63221 (/IDA) P63221 (/IDA) P63221 (/IDA) P63221 (/IDA) P63221 (/IDA) P63221 (/IDA) P63221 (/IDA) P63221 (/IDA) P63221 (/IDA)
(33 more)
Cytosolic small ribosomal subunit GO:0022627
The small subunit of a ribosome located in the cytosol.
6 O76927 (/TAS) O76927 (/TAS) O76927 (/TAS) O76927 (/TAS) O76927 (/TAS) P05764 (/TAS)
Ribosome GO:0005840
An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins.
5 O76927 (/IDA) O76927 (/IDA) O76927 (/IDA) O76927 (/IDA) O76927 (/IDA)
Cytosolic ribosome GO:0022626
A ribosome located in the cytosol.
5 O76927 (/HDA) O76927 (/HDA) O76927 (/HDA) O76927 (/HDA) O76927 (/HDA)
Cytosolic small ribosomal subunit GO:0022627
The small subunit of a ribosome located in the cytosol.
3 Q9CQR2 (/ISO) Q9CQR2 (/ISO) Q9CQR2 (/ISO)
Polysomal ribosome GO:0042788
A ribosome bound to mRNA that forms part of a polysome.
3 Q9CQR2 (/ISO) Q9CQR2 (/ISO) Q9CQR2 (/ISO)
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
3 Q9CQR2 (/EXP) Q9CQR2 (/EXP) Q9CQR2 (/EXP)
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
3 Q9CQR2 (/IDA) Q9CQR2 (/IDA) Q9CQR2 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P05764 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P05764 (/HDA)
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