The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Aldolase class I
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 21: Fructose-bisphosphate aldolase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 34 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Fructose-bisphosphate aldolase activity GO:0004332
Catalysis of the reaction: D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde-3-phosphate.
22 P00883 (/IDA) P00884 (/IDA) P04075 (/IDA) P04075 (/IDA) P04075 (/IDA) P04075 (/IDA) P05062 (/IDA) P05062 (/IDA) P05064 (/IDA) P05064 (/IDA)
(12 more)
Fructose-bisphosphate aldolase activity GO:0004332
Catalysis of the reaction: D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde-3-phosphate.
14 A5A6I5 (/ISS) P05063 (/ISS) P05064 (/ISS) P05064 (/ISS) P05064 (/ISS) P05064 (/ISS) P05065 (/ISS) P09117 (/ISS) P53448 (/ISS) Q5NVR5 (/ISS)
(4 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
13 P00883 (/IPI) P04075 (/IPI) P04075 (/IPI) P04075 (/IPI) P04075 (/IPI) P05062 (/IPI) P05062 (/IPI) P05065 (/IPI) P09117 (/IPI) P09972 (/IPI)
(3 more)
Cytoskeletal protein binding GO:0008092
Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton).
10 P04075 (/IDA) P04075 (/IDA) P04075 (/IDA) P04075 (/IDA) P05062 (/IDA) P05062 (/IDA) P09972 (/IDA) P09972 (/IDA) P09972 (/IDA) P09972 (/IDA)
Fructose-bisphosphate aldolase activity GO:0004332
Catalysis of the reaction: D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde-3-phosphate.
7 P00883 (/IMP) P05064 (/IMP) P05064 (/IMP) P05064 (/IMP) P05064 (/IMP) Q91Y97 (/IMP) Q91Y97 (/IMP)
Fructose-bisphosphate aldolase activity GO:0004332
Catalysis of the reaction: D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde-3-phosphate.
7 P05063 (/ISO) P05064 (/ISO) P05064 (/ISO) P05064 (/ISO) P05064 (/ISO) Q91Y97 (/ISO) Q91Y97 (/ISO)
Cytoskeletal protein binding GO:0008092
Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton).
7 P05063 (/ISO) P05064 (/ISO) P05064 (/ISO) P05064 (/ISO) P05064 (/ISO) Q91Y97 (/ISO) Q91Y97 (/ISO)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
6 P05064 (/ISO) P05064 (/ISO) P05064 (/ISO) P05064 (/ISO) Q91Y97 (/ISO) Q91Y97 (/ISO)
Fructose binding GO:0070061
Interacting selectively and non-covalently with the D- or L-enantiomer of fructose, the ketohexose arabino-hex-2-ulose.
6 P05064 (/ISO) P05064 (/ISO) P05064 (/ISO) P05064 (/ISO) Q91Y97 (/ISO) Q91Y97 (/ISO)
Protease binding GO:0002020
Interacting selectively and non-covalently with any protease or peptidase.
4 P05064 (/IPI) P05064 (/IPI) P05064 (/IPI) P05064 (/IPI)
Showing 1 to 10 of 34 entries

There are 92 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Gluconeogenesis GO:0006094
The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol.
11 P04075 (/TAS) P04075 (/TAS) P04075 (/TAS) P04075 (/TAS) P05062 (/TAS) P05062 (/TAS) P07341 (/TAS) P09972 (/TAS) P09972 (/TAS) P09972 (/TAS)
(1 more)
Protein homotetramerization GO:0051289
The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.
11 A5A6I5 (/ISS) P04075 (/ISS) P04075 (/ISS) P04075 (/ISS) P04075 (/ISS) P05064 (/ISS) P05064 (/ISS) P05064 (/ISS) P05064 (/ISS) P05065 (/ISS)
(1 more)
Fructose 1,6-bisphosphate metabolic process GO:0030388
The chemical reactions and pathways involving fructose 1,6-bisphosphate, also known as FBP. The D enantiomer is a metabolic intermediate in glycolysis and gluconeogenesis.
10 P04075 (/IDA) P04075 (/IDA) P04075 (/IDA) P04075 (/IDA) P05062 (/IDA) P05062 (/IDA) P09972 (/IDA) P09972 (/IDA) P09972 (/IDA) P09972 (/IDA)
Canonical glycolysis GO:0061621
The glycolytic process that begins with the conversion of glucose to glucose-6-phosphate by glucokinase activity. Glycolytic processes are the chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP.
10 P04075 (/TAS) P04075 (/TAS) P04075 (/TAS) P04075 (/TAS) P05062 (/TAS) P05062 (/TAS) P09972 (/TAS) P09972 (/TAS) P09972 (/TAS) P09972 (/TAS)
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
8 P04075 (/TAS) P04075 (/TAS) P04075 (/TAS) P04075 (/TAS) P09972 (/TAS) P09972 (/TAS) P09972 (/TAS) P09972 (/TAS)
Glycolytic process GO:0006096
The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules.
7 A5A6I5 (/ISS) P05064 (/ISS) P05064 (/ISS) P05064 (/ISS) P05064 (/ISS) P05065 (/ISS) Q5NVR5 (/ISS)
Fructose 1,6-bisphosphate metabolic process GO:0030388
The chemical reactions and pathways involving fructose 1,6-bisphosphate, also known as FBP. The D enantiomer is a metabolic intermediate in glycolysis and gluconeogenesis.
7 P05063 (/ISO) P05064 (/ISO) P05064 (/ISO) P05064 (/ISO) P05064 (/ISO) Q91Y97 (/ISO) Q91Y97 (/ISO)
Fructose 1,6-bisphosphate metabolic process GO:0030388
The chemical reactions and pathways involving fructose 1,6-bisphosphate, also known as FBP. The D enantiomer is a metabolic intermediate in glycolysis and gluconeogenesis.
7 P05063 (/ISS) P09117 (/ISS) P53448 (/ISS) Q5R1X4 (/ISS) Q9GKW3 (/ISS) Q9GKW3 (/ISS) Q9GKW3 (/ISS)
Fructose metabolic process GO:0006000
The chemical reactions and pathways involving fructose, the ketohexose arabino-2-hexulose. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey.
6 P04075 (/IMP) P04075 (/IMP) P04075 (/IMP) P04075 (/IMP) P05062 (/IMP) P05062 (/IMP)
Fructose metabolic process GO:0006000
The chemical reactions and pathways involving fructose, the ketohexose arabino-2-hexulose. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey.
6 P05064 (/ISO) P05064 (/ISO) P05064 (/ISO) P05064 (/ISO) Q91Y97 (/ISO) Q91Y97 (/ISO)
Showing 1 to 10 of 92 entries

There are 64 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
13 H3BQN4 (/IDA) H3BQN4 (/IDA) J3KPS3 (/IDA) J3KPS3 (/IDA) P00884 (/IDA) P04075 (/IDA) P04075 (/IDA) P04075 (/IDA) P04075 (/IDA) V9HWN7 (/IDA)
(3 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
11 P04075 (/TAS) P04075 (/TAS) P04075 (/TAS) P04075 (/TAS) P05062 (/TAS) P05062 (/TAS) P07341 (/TAS) P09972 (/TAS) P09972 (/TAS) P09972 (/TAS)
(1 more)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
10 P04075 (/HDA) P04075 (/HDA) P04075 (/HDA) P04075 (/HDA) P05062 (/HDA) P05062 (/HDA) P09972 (/HDA) P09972 (/HDA) P09972 (/HDA) P09972 (/HDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
8 P04075 (/TAS) P04075 (/TAS) P04075 (/TAS) P04075 (/TAS) P09972 (/TAS) P09972 (/TAS) P09972 (/TAS) P09972 (/TAS)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
8 P04075 (/HDA) P04075 (/HDA) P04075 (/HDA) P04075 (/HDA) P05064 (/HDA) P05064 (/HDA) P05064 (/HDA) P05064 (/HDA)
Secretory granule lumen GO:0034774
The volume enclosed by the membrane of a secretory granule.
8 P04075 (/TAS) P04075 (/TAS) P04075 (/TAS) P04075 (/TAS) P09972 (/TAS) P09972 (/TAS) P09972 (/TAS) P09972 (/TAS)
Tertiary granule lumen GO:1904724
Any membrane-enclosed lumen that is part of a tertiary granule.
8 P04075 (/TAS) P04075 (/TAS) P04075 (/TAS) P04075 (/TAS) P09972 (/TAS) P09972 (/TAS) P09972 (/TAS) P09972 (/TAS)
Ficolin-1-rich granule lumen GO:1904813
Any membrane-enclosed lumen that is part of a ficolin-1-rich granule.
8 P04075 (/TAS) P04075 (/TAS) P04075 (/TAS) P04075 (/TAS) P09972 (/TAS) P09972 (/TAS) P09972 (/TAS) P09972 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
7 P00884 (/IDA) P05064 (/IDA) P05064 (/IDA) P05064 (/IDA) P05064 (/IDA) P05065 (/IDA) P09117 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
7 P05063 (/ISO) P05064 (/ISO) P05064 (/ISO) P05064 (/ISO) P05064 (/ISO) Q91Y97 (/ISO) Q91Y97 (/ISO)
Showing 1 to 10 of 64 entries
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