The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Homocysteine-binding-like domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 3: Betaine--homocysteine S-methyltransferase 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 13 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
4 Q93088 (/IDA) Q93088 (/IDA) Q9H2M3 (/IDA) Q9H2M3 (/IDA)
Betaine-homocysteine S-methyltransferase activity GO:0047150
Catalysis of the reaction: L-homocysteine + betaine = N,N-dimethylglycine + L-methionine.
4 O09171 (/IDA) O35490 (/IDA) Q93088 (/IDA) Q93088 (/IDA)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
2 O35490 (/ISO) Q91WS4 (/ISO)
Betaine-homocysteine S-methyltransferase activity GO:0047150
Catalysis of the reaction: L-homocysteine + betaine = N,N-dimethylglycine + L-methionine.
2 Q93088 (/NAS) Q93088 (/NAS)
S-methylmethionine-homocysteine S-methyltransferase activity GO:0061627
Catalysis of the reaction: S-methyl-L-methionine + L-homocysteine = 2 L-methionine + H+.
2 Q9H2M3 (/IDA) Q9H2M3 (/IDA)
Methyltransferase activity GO:0008168
Catalysis of the transfer of a methyl group to an acceptor molecule.
1 O09171 (/IDA)
Methyltransferase activity GO:0008168
Catalysis of the transfer of a methyl group to an acceptor molecule.
1 O35490 (/ISO)
S-adenosylmethionine-homocysteine S-methyltransferase activity GO:0008898
Catalysis of the reaction: S-adenosyl-L-methionine + L-homocysteine = S-adenosyl-L-homocysteine + L-methionine.
1 Q91WS4 (/ISO)
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
1 O09171 (/IDA)
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
1 O35490 (/ISO)
Betaine-homocysteine S-methyltransferase activity GO:0047150
Catalysis of the reaction: L-homocysteine + betaine = N,N-dimethylglycine + L-methionine.
1 O09171 (/IMP)
Betaine-homocysteine S-methyltransferase activity GO:0047150
Catalysis of the reaction: L-homocysteine + betaine = N,N-dimethylglycine + L-methionine.
1 O35490 (/ISO)
S-methylmethionine-homocysteine S-methyltransferase activity GO:0061627
Catalysis of the reaction: S-methyl-L-methionine + L-homocysteine = 2 L-methionine + H+.
1 Q91WS4 (/ISO)

There are 19 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Sulfur amino acid metabolic process GO:0000096
The chemical reactions and pathways involving amino acids containing sulfur, comprising cysteine, homocysteine, methionine and selenocysteine.
4 Q93088 (/TAS) Q93088 (/TAS) Q9H2M3 (/TAS) Q9H2M3 (/TAS)
L-methionine salvage GO:0071267
Any process that generates L-methionine from derivatives of it, without de novo synthesis.
4 Q93088 (/IDA) Q93088 (/IDA) Q9H2M3 (/IDA) Q9H2M3 (/IDA)
Protein methylation GO:0006479
The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom.
2 Q93088 (/NAS) Q93088 (/NAS)
Amino-acid betaine metabolic process GO:0006577
The chemical reactions and pathways involving any betaine, the N-trimethyl derivative of an amino acid.
2 Q93088 (/IDA) Q93088 (/IDA)
Methionine biosynthetic process GO:0009086
The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins.
2 O09171 (/IDA) O35490 (/IDA)
Methionine biosynthetic process GO:0009086
The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins.
2 O35490 (/ISO) Q91WS4 (/ISO)
S-methylmethionine metabolic process GO:0033477
The chemical reactions and pathways involving S-methyl-methionine (SMM). SMM can be converted to methionine by donating a methyl group to homocysteine, and concurrent operation of this reaction and that mediated by MMT sets up the SMM cycle.
2 Q9H2M3 (/IDA) Q9H2M3 (/IDA)
Choline catabolic process GO:0042426
The chemical reactions and pathways resulting in the breakdown of choline (2-hydroxyethyltrimethylammonium), an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine.
2 Q93088 (/TAS) Q93088 (/TAS)
S-adenosylmethionine metabolic process GO:0046500
The chemical reactions and pathways involving S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism.
2 Q9H2M3 (/IDA) Q9H2M3 (/IDA)
Regulation of homocysteine metabolic process GO:0050666
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid.
2 Q93088 (/NAS) Q93088 (/NAS)
L-methionine salvage GO:0071267
Any process that generates L-methionine from derivatives of it, without de novo synthesis.
2 O35490 (/ISO) Q91WS4 (/ISO)
Type B pancreatic cell development GO:0003323
The process whose specific outcome is the progression of a type B pancreatic cell over time, from its formation to the mature structure. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin.
1 Q32LQ4 (/IMP)
Protein methylation GO:0006479
The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom.
1 O09171 (/IDA)
Protein methylation GO:0006479
The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom.
1 O35490 (/ISO)
Amino-acid betaine metabolic process GO:0006577
The chemical reactions and pathways involving any betaine, the N-trimethyl derivative of an amino acid.
1 O35490 (/ISO)
Response to organonitrogen compound GO:0010243
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond.
1 O09171 (/IEP)
S-methylmethionine metabolic process GO:0033477
The chemical reactions and pathways involving S-methyl-methionine (SMM). SMM can be converted to methionine by donating a methyl group to homocysteine, and concurrent operation of this reaction and that mediated by MMT sets up the SMM cycle.
1 Q91WS4 (/ISO)
S-adenosylmethionine metabolic process GO:0046500
The chemical reactions and pathways involving S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism.
1 Q91WS4 (/ISO)
Digestive system development GO:0055123
The process whose specific outcome is the progression of the digestive system over time, from its formation to the mature structure. The digestive system is the entire structure in which digestion takes place. Digestion is all of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.
1 Q32LQ4 (/IMP)

There are 8 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
5 O09171 (/IDA) Q93088 (/IDA) Q93088 (/IDA) V9HWA4 (/IDA) V9HWA4 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
4 Q93088 (/TAS) Q93088 (/TAS) Q9H2M3 (/TAS) Q9H2M3 (/TAS)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
4 Q93088 (/HDA) Q93088 (/HDA) Q9H2M3 (/HDA) Q9H2M3 (/HDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
2 Q93088 (/IDA) Q93088 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 O35490 (/ISO)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
1 O09171 (/IDA)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
1 O35490 (/ISO)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 O35490 (/ISO)
CATH-Gene3D is a Global Biodata Core Resource Learn more...