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CATH Superfamily 3.20.170.30

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: Phosphotransferase, putative

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
2'-phosphotransferase. [EC: 2.7.1.160]
2'-phospho-[ligated tRNA] + NAD(+) = mature tRNA + ADP ribose 1'',2''-phosphate + nicotinamide + H(2)O.
  • Catalyzes the final step of tRNA splicing in the yeast Saccharomyces cerevisiae.
  • The reaction takes place in two steps: in the first step, the 2'-phosphate on the RNA substrate is ADP-ribosylated, causing the relase of nicotinamide and the formation of the reaction intermediate, ADP-ribosylated tRNA.
  • In the second step, dephosphorylated (mature) tRNA is formed along with ADP ribose 1'',2''-cyclic phosphate.
  • Highly specific for oligonucleotide substrates bearing an internal 2'-phosphate.
  • Oligonucleotides with only a terminal 5'- or 3'-phosphate are not substrates.
 6 N1NX51 N1NX51 O14045 Q12272 Q12272 Q8K3A2