The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
SRCR-like domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 7: Soluble scavenger receptor cysteine-rich domain-co...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 9 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
10 A1L4H1 (/IPI) A1L4H1 (/IPI) A1L4H1 (/IPI) A1L4H1 (/IPI) A1L4H1 (/IPI) Q8BV57 (/IPI) Q8BV57 (/IPI) Q8BV57 (/IPI) Q8BV57 (/IPI) Q8BV57 (/IPI)
Fibronectin binding GO:0001968
Interacting selectively and non-covalently with a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids.
5 Q8BV57 (/IDA) Q8BV57 (/IDA) Q8BV57 (/IDA) Q8BV57 (/IDA) Q8BV57 (/IDA)
Fibronectin binding GO:0001968
Interacting selectively and non-covalently with a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids.
5 A1L4H1 (/ISS) A1L4H1 (/ISS) A1L4H1 (/ISS) A1L4H1 (/ISS) A1L4H1 (/ISS)
Scavenger receptor activity GO:0005044
Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs).
5 Q8BV57 (/IDA) Q8BV57 (/IDA) Q8BV57 (/IDA) Q8BV57 (/IDA) Q8BV57 (/IDA)
Scavenger receptor activity GO:0005044
Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs).
5 A1L4H1 (/ISS) A1L4H1 (/ISS) A1L4H1 (/ISS) A1L4H1 (/ISS) A1L4H1 (/ISS)
Laminin binding GO:0043236
Interacting selectively and non-covalently with laminins, glycoproteins that are major constituents of the basement membrane of cells.
5 Q8BV57 (/IDA) Q8BV57 (/IDA) Q8BV57 (/IDA) Q8BV57 (/IDA) Q8BV57 (/IDA)
Laminin binding GO:0043236
Interacting selectively and non-covalently with laminins, glycoproteins that are major constituents of the basement membrane of cells.
5 A1L4H1 (/ISS) A1L4H1 (/ISS) A1L4H1 (/ISS) A1L4H1 (/ISS) A1L4H1 (/ISS)
Extracellular matrix binding GO:0050840
Interacting selectively and non-covalently with a component of the extracellular matrix.
5 Q8BV57 (/IDA) Q8BV57 (/IDA) Q8BV57 (/IDA) Q8BV57 (/IDA) Q8BV57 (/IDA)
Extracellular matrix binding GO:0050840
Interacting selectively and non-covalently with a component of the extracellular matrix.
5 A1L4H1 (/ISS) A1L4H1 (/ISS) A1L4H1 (/ISS) A1L4H1 (/ISS) A1L4H1 (/ISS)

There are 9 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Defense response GO:0006952
Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.
5 Q8BV57 (/IDA) Q8BV57 (/IDA) Q8BV57 (/IDA) Q8BV57 (/IDA) Q8BV57 (/IDA)
Detection of bacterial lipoprotein GO:0042494
The series of events in which a bacterial lipoprotein stimulus is received by a cell and converted into a molecular signal. Bacterial lipoproteins are lipoproteins characterized by the presence of conserved sequence motifs called pathogen-associated molecular patterns (PAMPs).
5 Q8BV57 (/IDA) Q8BV57 (/IDA) Q8BV57 (/IDA) Q8BV57 (/IDA) Q8BV57 (/IDA)
Detection of bacterial lipoprotein GO:0042494
The series of events in which a bacterial lipoprotein stimulus is received by a cell and converted into a molecular signal. Bacterial lipoproteins are lipoproteins characterized by the presence of conserved sequence motifs called pathogen-associated molecular patterns (PAMPs).
5 A1L4H1 (/ISS) A1L4H1 (/ISS) A1L4H1 (/ISS) A1L4H1 (/ISS) A1L4H1 (/ISS)
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
5 Q8BV57 (/NAS) Q8BV57 (/NAS) Q8BV57 (/NAS) Q8BV57 (/NAS) Q8BV57 (/NAS)
Defense response to Gram-negative bacterium GO:0050829
Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism.
5 Q8BV57 (/IDA) Q8BV57 (/IDA) Q8BV57 (/IDA) Q8BV57 (/IDA) Q8BV57 (/IDA)
Defense response to Gram-positive bacterium GO:0050830
Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism.
5 Q8BV57 (/IDA) Q8BV57 (/IDA) Q8BV57 (/IDA) Q8BV57 (/IDA) Q8BV57 (/IDA)
Regulation of interleukin-8 secretion GO:2000482
Any process that modulates the frequency, rate or extent of interleukin-8 secretion.
5 Q8BV57 (/IDA) Q8BV57 (/IDA) Q8BV57 (/IDA) Q8BV57 (/IDA) Q8BV57 (/IDA)
Negative regulation of interleukin-8 secretion GO:2000483
Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-8 secretion.
5 Q8BV57 (/IDA) Q8BV57 (/IDA) Q8BV57 (/IDA) Q8BV57 (/IDA) Q8BV57 (/IDA)
Negative regulation of interleukin-8 secretion GO:2000483
Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-8 secretion.
5 A1L4H1 (/ISS) A1L4H1 (/ISS) A1L4H1 (/ISS) A1L4H1 (/ISS) A1L4H1 (/ISS)

There are 7 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
5 Q8BV57 (/TAS) Q8BV57 (/TAS) Q8BV57 (/TAS) Q8BV57 (/TAS) Q8BV57 (/TAS)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
5 Q8BV57 (/HDA) Q8BV57 (/HDA) Q8BV57 (/HDA) Q8BV57 (/HDA) Q8BV57 (/HDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
5 Q8BV57 (/IDA) Q8BV57 (/IDA) Q8BV57 (/IDA) Q8BV57 (/IDA) Q8BV57 (/IDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
5 A1L4H1 (/ISS) A1L4H1 (/ISS) A1L4H1 (/ISS) A1L4H1 (/ISS) A1L4H1 (/ISS)
Collagen-containing extracellular matrix GO:0062023
An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells.
5 Q8BV57 (/IDA) Q8BV57 (/IDA) Q8BV57 (/IDA) Q8BV57 (/IDA) Q8BV57 (/IDA)
Collagen-containing extracellular matrix GO:0062023
An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells.
5 A1L4H1 (/ISS) A1L4H1 (/ISS) A1L4H1 (/ISS) A1L4H1 (/ISS) A1L4H1 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 A4IG31 (/IDA) F6PEI8 (/IDA)
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