The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 4: Lactoylglutathione lyase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 3 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Lactoylglutathione lyase activity GO:0004462
Catalysis of the reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal.
18 O65398 (/IDA) O65398 (/IDA) O65398 (/IDA) O65398 (/IDA) Q6XC06 (/IDA) Q6XC06 (/IDA) Q8W593 (/IDA) Q8W593 (/IDA) Q8W593 (/IDA) Q8W593 (/IDA)
(8 more)
Nickel cation binding GO:0016151
Interacting selectively and non-covalently with nickel (Ni) cations.
8 Q948T6 (/IDA) Q948T6 (/IDA) Q948T6 (/IDA) Q948T6 (/IDA) Q948T6 (/IDA) Q948T6 (/IDA) Q948T6 (/IDA) Q948T6 (/IDA)
IgE binding GO:0019863
Interacting selectively and non-covalently with an immunoglobulin of the IgE isotype.
8 Q948T6 (/IDA) Q948T6 (/IDA) Q948T6 (/IDA) Q948T6 (/IDA) Q948T6 (/IDA) Q948T6 (/IDA) Q948T6 (/IDA) Q948T6 (/IDA)

There are 10 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Response to osmotic stress GO:0006970
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.
8 Q948T6 (/IMP) Q948T6 (/IMP) Q948T6 (/IMP) Q948T6 (/IMP) Q948T6 (/IMP) Q948T6 (/IMP) Q948T6 (/IMP) Q948T6 (/IMP)
Response to oxidative stress GO:0006979
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
8 Q948T6 (/IDA) Q948T6 (/IDA) Q948T6 (/IDA) Q948T6 (/IDA) Q948T6 (/IDA) Q948T6 (/IDA) Q948T6 (/IDA) Q948T6 (/IDA)
Response to salt stress GO:0009651
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
8 Q948T6 (/IDA) Q948T6 (/IDA) Q948T6 (/IDA) Q948T6 (/IDA) Q948T6 (/IDA) Q948T6 (/IDA) Q948T6 (/IDA) Q948T6 (/IDA)
Methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione GO:0019243
The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, into D-lactate via the intermediate S-lactoyl-glutathione. Glutathione is used in the first step of the pathway and then regenerated in the second step.
8 O65398 (/IGI) O65398 (/IGI) O65398 (/IGI) O65398 (/IGI) Q8W593 (/IGI) Q8W593 (/IGI) Q8W593 (/IGI) Q8W593 (/IGI)
Methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione GO:0019243
The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, into D-lactate via the intermediate S-lactoyl-glutathione. Glutathione is used in the first step of the pathway and then regenerated in the second step.
8 Q948T6 (/IMP) Q948T6 (/IMP) Q948T6 (/IMP) Q948T6 (/IMP) Q948T6 (/IMP) Q948T6 (/IMP) Q948T6 (/IMP) Q948T6 (/IMP)
Response to cold GO:0009409
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism.
4 Q8W593 (/IEP) Q8W593 (/IEP) Q8W593 (/IEP) Q8W593 (/IEP)
Response to cadmium ion GO:0046686
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.
4 O65398 (/IEP) O65398 (/IEP) O65398 (/IEP) O65398 (/IEP)
Response to water deprivation GO:0009414
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water.
2 O04818 (/TAS) O04818 (/TAS)
Aflatoxin biosynthetic process GO:0045122
The chemical reactions and pathways resulting in the formation of aflatoxin, a fungal metabolite found as a contaminant in moldy grains that induces liver cancer. Aflatoxin induces a G to T transversion at codon 249 of p53, leading to its inactivation. Aflatoxin is converted to a chemical carcinogen by P450.
2 Q6XC06 (/TAS) Q6XC06 (/TAS)
Defense response to fungus GO:0050832
Reactions triggered in response to the presence of a fungus that act to protect the cell or organism.
2 Q6XC06 (/IDA) Q6XC06 (/IDA)

There are 10 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Vacuole GO:0005773
A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.
4 O65398 (/IDA) O65398 (/IDA) O65398 (/IDA) O65398 (/IDA)
Peroxisome GO:0005777
A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
4 O65398 (/IDA) O65398 (/IDA) O65398 (/IDA) O65398 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
4 O65398 (/IDA) O65398 (/IDA) O65398 (/IDA) O65398 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
4 O65398 (/IDA) O65398 (/IDA) O65398 (/IDA) O65398 (/IDA)
Chloroplast GO:0009507
A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
4 Q8W593 (/IDA) Q8W593 (/IDA) Q8W593 (/IDA) Q8W593 (/IDA)
Chloroplast stroma GO:0009570
The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis.
4 Q8W593 (/IDA) Q8W593 (/IDA) Q8W593 (/IDA) Q8W593 (/IDA)
Thylakoid GO:0009579
A membranous cellular structure that bears the photosynthetic pigments in plants, algae, and cyanobacteria. In cyanobacteria thylakoids are of various shapes and are attached to, or continuous with, the plasma membrane. In eukaryotes they are flattened, membrane-bounded disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation.
4 Q8W593 (/IDA) Q8W593 (/IDA) Q8W593 (/IDA) Q8W593 (/IDA)
Chloroplast envelope GO:0009941
The double lipid bilayer enclosing the chloroplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space.
4 O65398 (/IDA) O65398 (/IDA) O65398 (/IDA) O65398 (/IDA)
Stromule GO:0010319
Thin filamentous structure extending from the surface of all plastid types examined so far, including chloroplast, proplastid, etioplast, leucoplast, amyloplast, and chromoplast. In general, stromules are more abundant in tissues containing non-green plastids, and in cells containing smaller plastids. The primary function of stromules is still unresolved, although the presence of stromules markedly increases the plastid surface area, potentially increasing transport to and from the cytosol. Other functions of stromules, such as transfer of macromolecules between plastids and starch granule formation in cereal endosperm, may be restricted to particular tissues and cell types.
4 Q8W593 (/IDA) Q8W593 (/IDA) Q8W593 (/IDA) Q8W593 (/IDA)
Thylakoid lumen GO:0031977
The volume enclosed by a thylakoid membrane.
4 Q8W593 (/IDA) Q8W593 (/IDA) Q8W593 (/IDA) Q8W593 (/IDA)
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