The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 11: Lactoylglutathione lyase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Lactoylglutathione lyase activity GO:0004462
Catalysis of the reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal.
15 A1Z6X6 (/ISS) Q4R5F2 (/ISS) Q4R5F2 (/ISS) Q4R5F2 (/ISS) Q4R5F2 (/ISS) Q4R5F2 (/ISS) Q4R5F2 (/ISS) Q4R5F2 (/ISS) Q4R5F2 (/ISS) Q4R5F2 (/ISS)
(5 more)
Lactoylglutathione lyase activity GO:0004462
Catalysis of the reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal.
6 B9DH52 (/IDA) Q04760 (/IDA) Q04760 (/IDA) Q6P7Q4 (/IDA) Q9CPU0 (/IDA) Q9CPU0 (/IDA)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
4 Q04760 (/IDA) Q04760 (/IDA) Q9CPU0 (/IDA) Q9CPU0 (/IDA)
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
3 Q8H0V3 (/IPI) Q8H0V3 (/IPI) Q8H0V3 (/IPI)
Lactoylglutathione lyase activity GO:0004462
Catalysis of the reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal.
2 Q9CPU0 (/ISO) Q9CPU0 (/ISO)
Lactoylglutathione lyase activity GO:0004462
Catalysis of the reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal.
2 Q04760 (/TAS) Q04760 (/TAS)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
2 Q9CPU0 (/ISO) Q9CPU0 (/ISO)

There are 21 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
14 Q4R5F2 (/ISS) Q4R5F2 (/ISS) Q4R5F2 (/ISS) Q4R5F2 (/ISS) Q4R5F2 (/ISS) Q4R5F2 (/ISS) Q4R5F2 (/ISS) Q4R5F2 (/ISS) Q4R5F2 (/ISS) Q5BL69 (/ISS)
(4 more)
Carbohydrate metabolic process GO:0005975
The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule.
2 Q9CPU0 (/ISO) Q9CPU0 (/ISO)
Carbohydrate metabolic process GO:0005975
The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule.
2 Q04760 (/NAS) Q04760 (/NAS)
Pyruvate metabolic process GO:0006090
The chemical reactions and pathways involving pyruvate, 2-oxopropanoate.
2 Q04760 (/TAS) Q04760 (/TAS)
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
2 Q9CPU0 (/IDA) Q9CPU0 (/IDA)
Glutathione metabolic process GO:0006749
The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle.
2 Q9CPU0 (/ISO) Q9CPU0 (/ISO)
Response to water deprivation GO:0009414
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water.
2 O04885 (/TAS) Q42891 (/TAS)
Methylglyoxal metabolic process GO:0009438
The chemical reactions and pathways involving methylglyoxal, CH3-CO-CHO, the aldehyde of pyruvic acid.
2 Q9CPU0 (/ISO) Q9CPU0 (/ISO)
Response to salt stress GO:0009651
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
2 O04885 (/TAS) Q42891 (/TAS)
Methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione GO:0019243
The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, into D-lactate via the intermediate S-lactoyl-glutathione. Glutathione is used in the first step of the pathway and then regenerated in the second step.
2 Q9CPU0 (/IC) Q9CPU0 (/IC)
Osteoclast differentiation GO:0030316
The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue.
2 Q9CPU0 (/IMP) Q9CPU0 (/IMP)
Osteoclast differentiation GO:0030316
The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue.
2 Q04760 (/ISS) Q04760 (/ISS)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
2 Q04760 (/IDA) Q04760 (/IDA)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
2 Q04760 (/IMP) Q04760 (/IMP)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
2 Q9CPU0 (/ISO) Q9CPU0 (/ISO)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
2 Q04760 (/TAS) Q04760 (/TAS)
Carbohydrate metabolic process GO:0005975
The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule.
1 Q6P7Q4 (/IDA)
Glutathione metabolic process GO:0006749
The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle.
1 Q6P7Q4 (/IDA)
Methylglyoxal metabolic process GO:0009438
The chemical reactions and pathways involving methylglyoxal, CH3-CO-CHO, the aldehyde of pyruvic acid.
1 Q6P7Q4 (/IDA)
Methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione GO:0019243
The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, into D-lactate via the intermediate S-lactoyl-glutathione. Glutathione is used in the first step of the pathway and then regenerated in the second step.
1 B9DH52 (/IGI)
Response to cadmium ion GO:0046686
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.
1 B9DH52 (/IEP)

There are 10 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
5 B9DH52 (/IDA) Q04760 (/IDA) Q04760 (/IDA) X5DNM4 (/IDA) X5DNM4 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
4 Q04760 (/IDA) Q04760 (/IDA) X5DNM4 (/IDA) X5DNM4 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
4 Q04760 (/IDA) Q04760 (/IDA) X5DNM4 (/IDA) X5DNM4 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 Q9CPU0 (/ISO) Q9CPU0 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q04760 (/TAS) Q04760 (/TAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 Q9CPU0 (/ISO) Q9CPU0 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 Q04760 (/TAS) Q04760 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 Q9CPU0 (/ISO) Q9CPU0 (/ISO)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
2 Q04760 (/HDA) Q04760 (/HDA)
Chloroplast GO:0009507
A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
1 B9DH52 (/IDA)
CATH-Gene3D is a Global Biodata Core Resource Learn more...