The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Mannose-Binding Protein A, subunit A
".
FunFam 24: C-type lectin domain family 4 member A
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 14 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
|
6 | D3ZWT9 (/ISS) Q3LUH2 (/ISS) Q67EQ0 (/ISS) Q9JKF4 (/ISS) Q9JKF4 (/ISS) Q9QZ15 (/ISS) |
|
Mannose binding GO:0005537
Interacting selectively and non-covalently with mannose, a monosaccharide hexose, stereoisomeric with glucose, that occurs naturally only in polymerized forms called mannans.
|
6 | D3ZWT9 (/ISS) Q3LUH2 (/ISS) Q67EQ0 (/ISS) Q9JKF4 (/ISS) Q9JKF4 (/ISS) Q9QZ15 (/ISS) |
|
Carbohydrate binding GO:0030246
Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates.
|
5 | D3ZWT9 (/ISS) Q3LUH2 (/ISS) Q67EQ0 (/ISS) Q6EIG7 (/ISS) Q9QZ15 (/ISS) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
4 | Q69FH1 (/IPI) Q8WXI8 (/IPI) Q9JKF4 (/IPI) Q9JKF4 (/IPI) |
|
Carbohydrate binding GO:0030246
Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates.
|
4 | Q6EIG7 (/IDA) Q9JKF4 (/IDA) Q9JKF4 (/IDA) Q9UMR7 (/IDA) |
|
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
|
3 | Q9JKF4 (/ISO) Q9JKF4 (/ISO) Q9QZ15 (/ISO) |
|
Mannose binding GO:0005537
Interacting selectively and non-covalently with mannose, a monosaccharide hexose, stereoisomeric with glucose, that occurs naturally only in polymerized forms called mannans.
|
3 | Q9JKF4 (/ISO) Q9JKF4 (/ISO) Q9QZ15 (/ISO) |
|
Carbohydrate binding GO:0030246
Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates.
|
3 | Q9JKF4 (/ISO) Q9JKF4 (/ISO) Q9QZ15 (/ISO) |
|
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
|
2 | Q6EIG7 (/IDA) Q9UMR7 (/IDA) |
|
Mannose binding GO:0005537
Interacting selectively and non-covalently with mannose, a monosaccharide hexose, stereoisomeric with glucose, that occurs naturally only in polymerized forms called mannans.
|
2 | Q6EIG7 (/IDA) Q9UMR7 (/IDA) |
|
Immunoglobulin receptor binding GO:0034987
Interacting selectively and non-covalently with one or more specific sites on an immunoglobulin receptor molecule.
|
2 | Q9Z2H6 (/IPI) Q9Z2H6 (/IPI) |
|
Transmembrane signaling receptor activity GO:0004888
Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.
|
1 | Q9UMR7 (/TAS) |
|
Carbohydrate binding GO:0030246
Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates.
|
1 | Q9QZ15 (/TAS) |
|
Carbohydrate derivative binding GO:0097367
Interacting selectively and non-covalently with a carbohydrate derivative.
|
1 | Q5YIR8 (/IDA) |
There are 36 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Stimulatory C-type lectin receptor signaling pathway GO:0002223
Any series of molecular signals generated as a consequence of binding to a C-type lectin receptor capable of cellular activation.
|
4 | Q6EIG7 (/TAS) Q8WTT0 (/TAS) Q8WXI8 (/TAS) Q9UMR7 (/TAS) |
|
Positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123
Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling.
|
3 | D3ZWT9 (/ISS) Q3LUH2 (/ISS) Q6EIG7 (/ISS) |
|
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
|
3 | D3ZWT9 (/ISS) Q3LUH2 (/ISS) Q6EIG7 (/ISS) |
|
Positive regulation of cytokine secretion GO:0050715
Any process that activates or increases the frequency, rate or extent of the regulated release of cytokines from a cell.
|
3 | D3ZWT9 (/ISS) Q3LUH2 (/ISS) Q6EIG7 (/ISS) |
|
Defense response to fungus GO:0050832
Reactions triggered in response to the presence of a fungus that act to protect the cell or organism.
|
3 | D3ZWT9 (/ISS) Q3LUH2 (/ISS) Q6EIG7 (/ISS) |
|
Negative regulation of cytokine production GO:0001818
Any process that stops, prevents, or reduces the rate of production of a cytokine.
|
2 | Q67EQ0 (/ISS) Q9QZ15 (/ISS) |
|
Adaptive immune response GO:0002250
An immune response mediated by cells expressing specific receptors for antigen produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory).
|
2 | Q9Z2H6 (/IMP) Q9Z2H6 (/IMP) |
|
T cell differentiation involved in immune response GO:0002292
The process in which an antigenically naive T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells.
|
2 | Q9Z2H6 (/IMP) Q9Z2H6 (/IMP) |
|
Plasmacytoid dendritic cell antigen processing and presentation GO:0002470
The process in which a plasmacytoid dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.
|
2 | Q67EQ0 (/ISS) Q9QZ15 (/ISS) |
|
Positive regulation of myeloid dendritic cell activation GO:0030887
Any process that stimulates, induces or increases the rate of myeloid dendritic cell activation.
|
2 | Q9Z2H6 (/IMP) Q9Z2H6 (/IMP) |
|
Positive regulation of myeloid dendritic cell activation GO:0030887
Any process that stimulates, induces or increases the rate of myeloid dendritic cell activation.
|
2 | Q69FH1 (/ISS) Q8WXI8 (/ISS) |
|
Negative regulation of tumor necrosis factor production GO:0032720
Any process that stops, prevents, or reduces the frequency, rate, or extent of tumor necrosis factor production.
|
2 | Q67EQ0 (/ISS) Q9QZ15 (/ISS) |
|
CD8-positive, alpha-beta T cell activation GO:0036037
The change in morphology and behavior of a CD8-positive, alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.
|
2 | Q67EQ0 (/ISS) Q9QZ15 (/ISS) |
|
Fc-gamma receptor signaling pathway GO:0038094
A series of molecular signals initiated by the binding of the Fc portion of immunoglobulin G (IgG) to an Fc-gamma receptor on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region.
|
2 | Q9Z2H6 (/IDA) Q9Z2H6 (/IDA) |
|
Antigen processing and presentation of exogenous peptide antigen via MHC class I GO:0042590
The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex. The peptide antigen is typically, but not always, processed from a whole protein. Class I here refers to classical class I molecules.
|
2 | Q67EQ0 (/ISS) Q9QZ15 (/ISS) |
|
Defense response to bacterium GO:0042742
Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
|
2 | Q9Z2H6 (/IMP) Q9Z2H6 (/IMP) |
|
Positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123
Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling.
|
2 | Q9JKF4 (/IDA) Q9JKF4 (/IDA) |
|
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
|
2 | Q8WTT0 (/TAS) Q8WXI8 (/TAS) |
|
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
|
2 | Q9JKF4 (/IDA) Q9JKF4 (/IDA) |
|
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
|
2 | Q9Z2H6 (/IMP) Q9Z2H6 (/IMP) |
|
Positive regulation of cytokine secretion GO:0050715
Any process that activates or increases the frequency, rate or extent of the regulated release of cytokines from a cell.
|
2 | Q9JKF4 (/IDA) Q9JKF4 (/IDA) |
|
Defense response to fungus GO:0050832
Reactions triggered in response to the presence of a fungus that act to protect the cell or organism.
|
2 | Q9JKF4 (/IDA) Q9JKF4 (/IDA) |
|
Positive regulation of release of sequestered calcium ion into cytosol GO:0051281
Any process that activates or increases the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria.
|
2 | Q7TS58 (/IDA) Q9D8Q7 (/IDA) |
|
Negative regulation of cytokine production GO:0001818
Any process that stops, prevents, or reduces the rate of production of a cytokine.
|
1 | Q9UMR7 (/IDA) |
|
Negative regulation of cytokine production GO:0001818
Any process that stops, prevents, or reduces the rate of production of a cytokine.
|
1 | Q9QZ15 (/ISO) |
|
Plasmacytoid dendritic cell antigen processing and presentation GO:0002470
The process in which a plasmacytoid dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.
|
1 | Q9UMR7 (/IDA) |
|
Plasmacytoid dendritic cell antigen processing and presentation GO:0002470
The process in which a plasmacytoid dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.
|
1 | Q9QZ15 (/ISO) |
|
Positive regulation of antigen processing and presentation GO:0002579
Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation.
|
1 | Q67DU8 (/IDA) |
|
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
|
1 | Q9UMR7 (/TAS) |
|
Cell surface receptor signaling pathway GO:0007166
A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
|
1 | Q9UMR7 (/TAS) |
|
Negative regulation of tumor necrosis factor production GO:0032720
Any process that stops, prevents, or reduces the frequency, rate, or extent of tumor necrosis factor production.
|
1 | Q9UMR7 (/IDA) |
|
Negative regulation of tumor necrosis factor production GO:0032720
Any process that stops, prevents, or reduces the frequency, rate, or extent of tumor necrosis factor production.
|
1 | Q9QZ15 (/ISO) |
|
CD8-positive, alpha-beta T cell activation GO:0036037
The change in morphology and behavior of a CD8-positive, alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.
|
1 | Q9UMR7 (/IDA) |
|
CD8-positive, alpha-beta T cell activation GO:0036037
The change in morphology and behavior of a CD8-positive, alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.
|
1 | Q9QZ15 (/ISO) |
|
Antigen processing and presentation of exogenous peptide antigen via MHC class I GO:0042590
The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex. The peptide antigen is typically, but not always, processed from a whole protein. Class I here refers to classical class I molecules.
|
1 | Q9UMR7 (/IDA) |
|
Antigen processing and presentation of exogenous peptide antigen via MHC class I GO:0042590
The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex. The peptide antigen is typically, but not always, processed from a whole protein. Class I here refers to classical class I molecules.
|
1 | Q9QZ15 (/ISO) |
There are 9 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
6 | Q6EIG7 (/TAS) Q8WTT0 (/TAS) Q8WXI8 (/TAS) Q9JKF4 (/TAS) Q9JKF4 (/TAS) Q9UMR7 (/TAS) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
2 | Q9Z2H6 (/IDA) Q9Z2H6 (/IDA) |
|
Tertiary granule membrane GO:0070821
The lipid bilayer surrounding a tertiary granule.
|
2 | Q8WTT0 (/TAS) Q8WXI8 (/TAS) |
|
Ficolin-1-rich granule membrane GO:0101003
The lipid bilayer surrounding a ficolin-1-rich granule.
|
2 | Q8WTT0 (/TAS) Q8WXI8 (/TAS) |
|
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
1 | Q9UMR7 (/TAS) |
|
External side of plasma membrane GO:0009897
The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
|
1 | Q67DU8 (/IDA) |
|
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
1 | Q9QZ15 (/TAS) |
|
Secretory granule membrane GO:0030667
The lipid bilayer surrounding a secretory granule.
|
1 | Q8WTT0 (/TAS) |
|
Specific granule membrane GO:0035579
The lipid bilayer surrounding a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase.
|
1 | Q8WXI8 (/TAS) |