The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 49: Interleukin-1 alpha

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 8 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Copper ion binding GO:0005507
Interacting selectively and non-covalently with copper (Cu) ions.
20 O46612 (/ISS) O46613 (/ISS) P01582 (/ISS) P01582 (/ISS) P04822 (/ISS) P04822 (/ISS) P04822 (/ISS) P08831 (/ISS) P16598 (/ISS) P18430 (/ISS)
(10 more)
Cytokine activity GO:0005125
Functions to control the survival, growth, differentiation and effector function of tissues and cells.
3 P01583 (/IMP) P01583 (/IMP) P01583 (/IMP)
Cytokine activity GO:0005125
Functions to control the survival, growth, differentiation and effector function of tissues and cells.
3 P01583 (/TAS) P01583 (/TAS) P01583 (/TAS)
Copper ion binding GO:0005507
Interacting selectively and non-covalently with copper (Cu) ions.
3 P01583 (/IDA) P01583 (/IDA) P01583 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
3 P01583 (/IPI) P01583 (/IPI) P01583 (/IPI)
Cytokine activity GO:0005125
Functions to control the survival, growth, differentiation and effector function of tissues and cells.
2 P01582 (/IDA) P01582 (/IDA)
Cytokine activity GO:0005125
Functions to control the survival, growth, differentiation and effector function of tissues and cells.
2 P01582 (/ISO) P01582 (/ISO)
Copper ion binding GO:0005507
Interacting selectively and non-covalently with copper (Cu) ions.
2 P01582 (/ISO) P01582 (/ISO)

There are 69 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cellular response to heat GO:0034605
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
20 O46612 (/ISS) O46613 (/ISS) P01582 (/ISS) P01582 (/ISS) P04822 (/ISS) P04822 (/ISS) P04822 (/ISS) P08831 (/ISS) P16598 (/ISS) P18430 (/ISS)
(10 more)
Response to copper ion GO:0046688
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus.
20 O46612 (/ISS) O46613 (/ISS) P01582 (/ISS) P01582 (/ISS) P04822 (/ISS) P04822 (/ISS) P04822 (/ISS) P08831 (/ISS) P16598 (/ISS) P18430 (/ISS)
(10 more)
Apoptotic process GO:0006915
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
3 P01583 (/TAS) P01583 (/TAS) P01583 (/TAS)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
3 P01583 (/IDA) P01583 (/IDA) P01583 (/IDA)
Positive regulation of vascular endothelial growth factor production GO:0010575
Any process that increases or activates the frequency, rate, or extent of production of vascular endothelial growth factor.
3 P01583 (/ISS) P01583 (/ISS) P01583 (/ISS)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
3 P01583 (/IDA) P01583 (/IDA) P01583 (/IDA)
Cytokine-mediated signaling pathway GO:0019221
A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
3 P01583 (/IMP) P01583 (/IMP) P01583 (/IMP)
Cytokine-mediated signaling pathway GO:0019221
A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
3 P01583 (/TAS) P01583 (/TAS) P01583 (/TAS)
Cellular response to heat GO:0034605
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
3 P01583 (/IDA) P01583 (/IDA) P01583 (/IDA)
Positive regulation of interleukin-2 biosynthetic process GO:0045086
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-2.
3 P01583 (/IMP) P01583 (/IMP) P01583 (/IMP)
Positive regulation of angiogenesis GO:0045766
Any process that activates or increases angiogenesis.
3 P01583 (/ISS) P01583 (/ISS) P01583 (/ISS)
Positive regulation of mitotic nuclear division GO:0045840
Any process that activates or increases the frequency, rate or extent of mitosis.
3 P01583 (/IMP) P01583 (/IMP) P01583 (/IMP)
Response to copper ion GO:0046688
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus.
3 P01583 (/IDA) P01583 (/IDA) P01583 (/IDA)
Positive regulation of protein secretion GO:0050714
Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell.
3 P01583 (/IMP) P01583 (/IMP) P01583 (/IMP)
Positive regulation of cytokine secretion GO:0050715
Any process that activates or increases the frequency, rate or extent of the regulated release of cytokines from a cell.
3 P01583 (/IDA) P01583 (/IDA) P01583 (/IDA)
Interleukin-1-mediated signaling pathway GO:0070498
A series of molecular signals initiated by the binding of interleukin-1 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
3 P01583 (/TAS) P01583 (/TAS) P01583 (/TAS)
Negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240
Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand.
3 P01583 (/TAS) P01583 (/TAS) P01583 (/TAS)
Connective tissue replacement involved in inflammatory response wound healing GO:0002248
The series of events leading to growth of connective tissue when loss of tissues that are incapable of regeneration occurs, or when fibrinous exudate cannot be adequately cleared that contribute to an inflammatory response.
2 P01582 (/IMP) P01582 (/IMP)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
2 P01582 (/ISO) P01582 (/ISO)
Positive regulation of vascular endothelial growth factor production GO:0010575
Any process that increases or activates the frequency, rate, or extent of production of vascular endothelial growth factor.
2 P01582 (/IMP) P01582 (/IMP)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
2 P01582 (/ISO) P01582 (/ISO)
Positive regulation of steroid biosynthetic process GO:0010893
Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.
2 P01582 (/ISO) P01582 (/ISO)
Cytokine-mediated signaling pathway GO:0019221
A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2 P01582 (/ISO) P01582 (/ISO)
Keratinization GO:0031424
The process in which the cytoplasm of the outermost cells of the vertebrate epidermis is replaced by keratin. Keratinization occurs in the stratum corneum, feathers, hair, claws, nails, hooves, and horns.
2 P01582 (/ISO) P01582 (/ISO)
Positive regulation of prostaglandin secretion GO:0032308
Any process that activates or increases the frequency, rate or extent of the regulated release of a prostaglandin from a cell.
2 P01582 (/ISO) P01582 (/ISO)
Positive regulation of interleukin-6 production GO:0032755
Any process that activates or increases the frequency, rate, or extent of interleukin-6 production.
2 P01582 (/ISO) P01582 (/ISO)
Positive regulation of stress-activated MAPK cascade GO:0032874
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade.
2 P01582 (/ISO) P01582 (/ISO)
Regulation of actin cytoskeleton organization GO:0032956
Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
2 P01582 (/ISO) P01582 (/ISO)
Cellular response to heat GO:0034605
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
2 P01582 (/ISO) P01582 (/ISO)
Ectopic germ cell programmed cell death GO:0035234
Programmed cell death of an errant germ line cell that is outside the normal migratory path or ectopic to the gonad. This is an important mechanism of regulating germ cell survival within the embryo.
2 P01582 (/IGI) P01582 (/IGI)
Positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123
Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling.
2 P01582 (/ISO) P01582 (/ISO)
Positive regulation of interleukin-2 biosynthetic process GO:0045086
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-2.
2 P01582 (/ISO) P01582 (/ISO)
Positive regulation of angiogenesis GO:0045766
Any process that activates or increases angiogenesis.
2 P01582 (/IMP) P01582 (/IMP)
Positive regulation of mitotic nuclear division GO:0045840
Any process that activates or increases the frequency, rate or extent of mitosis.
2 P01582 (/ISO) P01582 (/ISO)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
2 P01582 (/IGI) P01582 (/IGI)
Positive regulation of JNK cascade GO:0046330
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade.
2 P01582 (/ISO) P01582 (/ISO)
Response to copper ion GO:0046688
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus.
2 P01582 (/ISO) P01582 (/ISO)
Positive regulation of protein secretion GO:0050714
Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell.
2 P01582 (/ISO) P01582 (/ISO)
Positive regulation of cytokine secretion GO:0050715
Any process that activates or increases the frequency, rate or extent of the regulated release of cytokines from a cell.
2 P01582 (/ISO) P01582 (/ISO)
Regulation of sensory perception of pain GO:0051930
Any process that modulates the frequency, rate or extent of the sensory perception of pain, the series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal.
2 P01582 (/ISO) P01582 (/ISO)
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
2 P01582 (/ISO) P01582 (/ISO)
Extrinsic apoptotic signaling pathway in absence of ligand GO:0097192
A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with withdrawal of a ligand from a cell surface receptor, and ends when the execution phase of apoptosis is triggered.
2 P01582 (/IMP) P01582 (/IMP)
Positive regulation of neutrophil migration GO:1902624
Any process that activates or increases the frequency, rate or extent of neutrophil migration.
2 P01582 (/ISO) P01582 (/ISO)
Negative regulation of establishment of Sertoli cell barrier GO:1904445
Any process that stops, prevents or reduces the frequency, rate or extent of establishment of Sertoli cell barrier.
2 P01582 (/ISO) P01582 (/ISO)
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
1 P16598 (/IEP)
Acute inflammatory response GO:0002526
Inflammation which comprises a rapid, short-lived, relatively uniform response to acute injury or antigenic challenge and is characterized by accumulations of fluid, plasma proteins, and granulocytic leukocytes. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response.
1 P16598 (/IEP)
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
1 P16598 (/IEP)
Heart development GO:0007507
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
1 P16598 (/IEP)
Response to heat GO:0009408
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
1 P16598 (/IEP)
Response to organic substance GO:0010033
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus.
1 P16598 (/IEP)
Response to ozone GO:0010193
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ozone stimulus.
1 P16598 (/IEP)
Response to organonitrogen compound GO:0010243
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond.
1 P16598 (/IEP)
Response to gamma radiation GO:0010332
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum.
1 P16598 (/IEP)
Positive regulation of steroid biosynthetic process GO:0010893
Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.
1 P16598 (/IDA)
Response to organic cyclic compound GO:0014070
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
1 P16598 (/IEP)
Keratinization GO:0031424
The process in which the cytoplasm of the outermost cells of the vertebrate epidermis is replaced by keratin. Keratinization occurs in the stratum corneum, feathers, hair, claws, nails, hooves, and horns.
1 P16598 (/IDA)
Positive regulation of prostaglandin secretion GO:0032308
Any process that activates or increases the frequency, rate or extent of the regulated release of a prostaglandin from a cell.
1 P16598 (/IDA)
Response to lipopolysaccharide GO:0032496
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
1 P16598 (/IEP)
Positive regulation of interleukin-6 production GO:0032755
Any process that activates or increases the frequency, rate, or extent of interleukin-6 production.
1 P16598 (/IMP)
Positive regulation of stress-activated MAPK cascade GO:0032874
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade.
1 P16598 (/IDA)
Regulation of actin cytoskeleton organization GO:0032956
Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
1 P16598 (/IDA)
Response to L-ascorbic acid GO:0033591
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an L-ascorbic acid (vitamin C) stimulus.
1 P16598 (/IEP)
Wound healing GO:0042060
The series of events that restore integrity to a damaged tissue, following an injury.
1 P16598 (/IEP)
Positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123
Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling.
1 P16598 (/IDA)
Positive regulation of JNK cascade GO:0046330
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade.
1 P16598 (/IDA)
Regulation of sensory perception of pain GO:0051930
Any process that modulates the frequency, rate or extent of the sensory perception of pain, the series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal.
1 P16598 (/IDA)
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
1 P16598 (/IDA)
Positive regulation of neutrophil migration GO:1902624
Any process that activates or increases the frequency, rate or extent of neutrophil migration.
1 P16598 (/IMP)
Negative regulation of establishment of Sertoli cell barrier GO:1904445
Any process that stops, prevents or reduces the frequency, rate or extent of establishment of Sertoli cell barrier.
1 P16598 (/IDA)

There are 13 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
20 O46612 (/ISS) O46613 (/ISS) P01582 (/ISS) P01582 (/ISS) P04822 (/ISS) P04822 (/ISS) P04822 (/ISS) P08831 (/ISS) P16598 (/ISS) P18430 (/ISS)
(10 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
20 O46612 (/ISS) O46613 (/ISS) P01582 (/ISS) P01582 (/ISS) P04822 (/ISS) P04822 (/ISS) P04822 (/ISS) P08831 (/ISS) P16598 (/ISS) P18430 (/ISS)
(10 more)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
6 P01582 (/IDA) P01582 (/IDA) P01583 (/IDA) P01583 (/IDA) P01583 (/IDA) P16598 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
4 P01583 (/IDA) P01583 (/IDA) P01583 (/IDA) P16598 (/IDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
3 P01583 (/TAS) P01583 (/TAS) P01583 (/TAS)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
3 P01583 (/IMP) P01583 (/IMP) P01583 (/IMP)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
3 P01583 (/TAS) P01583 (/TAS) P01583 (/TAS)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
2 P01582 (/ISO) P01582 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 P01582 (/ISO) P01582 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 P01582 (/ISO) P01582 (/ISO)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
2 P01582 (/ISO) P01582 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P16598 (/IDA)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
1 P16598 (/IDA)
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