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CATH Superfamily 2.80.10.50

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 43: Interleukin-18

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 9 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Cytokine activity GO:0005125
Functions to control the survival, growth, differentiation and effector function of tissues and cells.
 17 O19073 (/ISS) O19073 (/ISS) P70380 (/ISS) P70380 (/ISS) P97636 (/ISS) Q14116 (/ISS) Q14116 (/ISS) Q14116 (/ISS) Q3ZT29 (/ISS) Q5I931 (/ISS)
(7 more)
Interleukin-18 receptor binding GO:0045515
Interacting selectively and non-covalently with the interleukin-18 receptor.
 14 O19073 (/ISS) O19073 (/ISS) P70380 (/ISS) P70380 (/ISS) P97636 (/ISS) Q3ZT29 (/ISS) Q5I931 (/ISS) Q95M33 (/ISS) Q95M33 (/ISS) Q9TU73 (/ISS)
(4 more)
Cytokine activity GO:0005125
Functions to control the survival, growth, differentiation and effector function of tissues and cells.
 5 P70380 (/IDA) P70380 (/IDA) Q14116 (/IDA) Q14116 (/IDA) Q14116 (/IDA)
Cytokine activity GO:0005125
Functions to control the survival, growth, differentiation and effector function of tissues and cells.
 4 O19073 (/IMP) O19073 (/IMP) P70380 (/IMP) P70380 (/IMP)
Cytokine activity GO:0005125
Functions to control the survival, growth, differentiation and effector function of tissues and cells.
 4 Q14116 (/TAS) Q14116 (/TAS) Q14116 (/TAS) Q9XSR0 (/TAS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
 4 P97636 (/IPI) Q14116 (/IPI) Q14116 (/IPI) Q14116 (/IPI)
Interleukin-18 receptor binding GO:0045515
Interacting selectively and non-covalently with the interleukin-18 receptor.
 3 Q14116 (/IDA) Q14116 (/IDA) Q14116 (/IDA)
Cytokine activity GO:0005125
Functions to control the survival, growth, differentiation and effector function of tissues and cells.
 2 P70380 (/ISO) P70380 (/ISO)
Interleukin-18 receptor binding GO:0045515
Interacting selectively and non-covalently with the interleukin-18 receptor.
 2 P70380 (/ISO) P70380 (/ISO)
Showing 1 to 9 of 9 entries

There are 148 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Positive regulation of NF-kappaB transcription factor activity GO:0051092
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
 14 O19073 (/ISS) O19073 (/ISS) P70380 (/ISS) P70380 (/ISS) P97636 (/ISS) Q3ZT29 (/ISS) Q5I931 (/ISS) Q95M33 (/ISS) Q95M33 (/ISS) Q9TU73 (/ISS)
(4 more)
Positive regulation of T-helper 1 cell cytokine production GO:2000556
Any process that activates or increases the frequency, rate or extent of T-helper 1 cell cytokine production.
 14 O19073 (/ISS) O19073 (/ISS) P70380 (/ISS) P70380 (/ISS) P97636 (/ISS) Q3ZT29 (/ISS) Q5I931 (/ISS) Q95M33 (/ISS) Q95M33 (/ISS) Q9TU73 (/ISS)
(4 more)
Positive regulation of interferon-gamma production GO:0032729
Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.
 12 O19073 (/ISS) O19073 (/ISS) P97636 (/ISS) Q3ZT29 (/ISS) Q5I931 (/ISS) Q95M33 (/ISS) Q95M33 (/ISS) Q9TU73 (/ISS) Q9TU73 (/ISS) Q9XSQ7 (/ISS)
(2 more)
Interleukin-18-mediated signaling pathway GO:0035655
A series of molecular signals initiated by the binding of interleukin-18 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
 12 O19073 (/ISS) O19073 (/ISS) P97636 (/ISS) Q3ZT29 (/ISS) Q5I931 (/ISS) Q95M33 (/ISS) Q95M33 (/ISS) Q9TU73 (/ISS) Q9TU73 (/ISS) Q9XSQ7 (/ISS)
(2 more)
Positive regulation of activated T cell proliferation GO:0042104
Any process that activates or increases the rate or extent of activated T cell proliferation.
 6 O19073 (/ISS) O19073 (/ISS) P70380 (/ISS) P70380 (/ISS) P97636 (/ISS) Q9XSR0 (/ISS)
Angiogenesis GO:0001525
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
 5 O19073 (/ISS) O19073 (/ISS) P70380 (/ISS) P70380 (/ISS) P97636 (/ISS)
Sleep GO:0030431
Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain.
 5 P70380 (/ISS) P70380 (/ISS) Q14116 (/ISS) Q14116 (/ISS) Q14116 (/ISS)
Positive regulation of interferon-gamma production GO:0032729
Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.
 5 P70380 (/IDA) P70380 (/IDA) Q14116 (/IDA) Q14116 (/IDA) Q14116 (/IDA)
Interleukin-18-mediated signaling pathway GO:0035655
A series of molecular signals initiated by the binding of interleukin-18 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
 5 P70380 (/IDA) P70380 (/IDA) Q14116 (/IDA) Q14116 (/IDA) Q14116 (/IDA)
Interleukin-13 biosynthetic process GO:0042231
The chemical reactions and pathways resulting in the formation of interleukin-13.
 5 P70380 (/TAS) P70380 (/TAS) Q14116 (/TAS) Q14116 (/TAS) Q14116 (/TAS)
Showing 1 to 10 of 148 entries

There are 8 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
 6 P70380 (/IDA) P70380 (/IDA) P97636 (/IDA) Q14116 (/IDA) Q14116 (/IDA) Q14116 (/IDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
 4 Q14116 (/TAS) Q14116 (/TAS) Q14116 (/TAS) Q9XSR0 (/TAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
 3 Q14116 (/TAS) Q14116 (/TAS) Q14116 (/TAS)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
 2 P70380 (/ISO) P70380 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
 2 P70380 (/ISO) P70380 (/ISO)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
 2 P70380 (/ISO) P70380 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
 1 P97636 (/IDA)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
 1 P97636 (/IDA)
Showing 1 to 8 of 8 entries
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