The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
PLAT/LH2 domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 3: Triacylglycerol lipase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 20 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Triglyceride lipase activity GO:0004806
Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate.
10 A5PK46 (/ISS) O88354 (/ISS) P00591 (/ISS) P16233 (/ISS) P29183 (/ISS) P50903 (/ISS) P54317 (/ISS) Q02157 (/ISS) Q64424 (/ISS) Q64425 (/ISS)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
8 A5PK46 (/ISS) P17892 (/ISS) P54315 (/ISS) P54316 (/ISS) P54318 (/ISS) P81139 (/ISS) Q5BKQ4 (/ISS) Q64424 (/ISS)
Triglyceride lipase activity GO:0004806
Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate.
5 P17892 (/IDA) P27657 (/IDA) P54318 (/IDA) P81139 (/IDA) Q6P8U6 (/IDA)
Acylglycerol lipase activity GO:0047372
Catalysis of the reaction: H2O + acylglycerol = a fatty acid + glycerol.
5 A5PK46 (/ISS) P17892 (/ISS) P54318 (/ISS) P81139 (/ISS) Q64424 (/ISS)
Phospholipase activity GO:0004620
Catalysis of the hydrolysis of a glycerophospholipid.
4 A5PK46 (/ISS) P17892 (/ISS) P81139 (/ISS) Q64424 (/ISS)
Lipase activity GO:0016298
Catalysis of the hydrolysis of a lipid or phospholipid.
4 P16233 (/IDA) P27657 (/IDA) P54316 (/IDA) P54318 (/IDA)
Galactolipase activity GO:0047714
Catalysis of the reaction: 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + 2 H2O = 3-beta-D-galactosyl-sn-glycerol + 2 carboxylates.
4 A5PK46 (/ISS) P17892 (/ISS) P81139 (/ISS) Q64424 (/ISS)
Triglyceride lipase activity GO:0004806
Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate.
3 P16233 (/TAS) P54315 (/TAS) P54317 (/TAS)
Lipase activity GO:0016298
Catalysis of the hydrolysis of a lipid or phospholipid.
3 P17892 (/ISO) Q5BKQ4 (/ISO) Q6P8U6 (/ISO)
Phospholipase activity GO:0004620
Catalysis of the hydrolysis of a glycerophospholipid.
2 P54317 (/IDA) P54318 (/IDA)
Triglyceride lipase activity GO:0004806
Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate.
2 A0MBZ6 (/IMP) G1NFD3 (/IMP)
Triglyceride lipase activity GO:0004806
Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate.
2 P17892 (/ISO) Q6P8U6 (/ISO)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
2 P06857 (/IDA) P54317 (/IDA)
Galactolipase activity GO:0047714
Catalysis of the reaction: 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + 2 H2O = 3-beta-D-galactosyl-sn-glycerol + 2 carboxylates.
2 P54317 (/IDA) P54318 (/IDA)
Phospholipase activity GO:0004620
Catalysis of the hydrolysis of a glycerophospholipid.
1 P17892 (/ISO)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
1 P17892 (/ISO)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 P54316 (/IPI)
Acylglycerol lipase activity GO:0047372
Catalysis of the reaction: H2O + acylglycerol = a fatty acid + glycerol.
1 P54317 (/IDA)
Acylglycerol lipase activity GO:0047372
Catalysis of the reaction: H2O + acylglycerol = a fatty acid + glycerol.
1 P17892 (/ISO)
Galactolipase activity GO:0047714
Catalysis of the reaction: 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + 2 H2O = 3-beta-D-galactosyl-sn-glycerol + 2 carboxylates.
1 P17892 (/ISO)

There are 26 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Phospholipid catabolic process GO:0009395
The chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester.
5 A5PK46 (/ISS) P17892 (/ISS) P54318 (/ISS) P81139 (/ISS) Q64424 (/ISS)
Galactolipid catabolic process GO:0019376
The chemical reactions and pathways resulting in the breakdown of galactolipids, any glycolipid containing one of more residues of galactose and/or N-acetylgalactosamine.
4 A5PK46 (/ISS) P17892 (/ISS) P81139 (/ISS) Q64424 (/ISS)
Response to peptide hormone GO:0043434
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals.
3 P27657 (/IEP) P54316 (/IEP) P54318 (/IEP)
Lipid metabolic process GO:0006629
The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
2 P27657 (/IDA) P81139 (/IDA)
Post-embryonic development GO:0009791
The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development.
2 P27657 (/IEP) P54318 (/IEP)
Galactolipid catabolic process GO:0019376
The chemical reactions and pathways resulting in the breakdown of galactolipids, any glycolipid containing one of more residues of galactose and/or N-acetylgalactosamine.
2 P54317 (/IDA) P54318 (/IDA)
Response to lipid GO:0033993
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus.
2 P27657 (/IEP) P54318 (/IEP)
Lipid digestion GO:0044241
The whole of the physical, chemical, and biochemical processes carried out by living organisms to break down ingested lipids into components that may be easily absorbed and directed into metabolism.
2 P16233 (/TAS) P54317 (/TAS)
Response to glucocorticoid GO:0051384
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.
2 P54316 (/IEP) P54318 (/IEP)
Retinoid metabolic process GO:0001523
The chemical reactions and pathways involving retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity.
1 P16233 (/TAS)
Lipid metabolic process GO:0006629
The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
1 P16233 (/IMP)
Lipid metabolic process GO:0006629
The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
1 Q6P8U6 (/ISO)
Triglyceride metabolic process GO:0006641
The chemical reactions and pathways involving triglyceride, any triester of glycerol. The three fatty acid residues may all be the same or differ in any permutation. Triglycerides are important components of plant oils, animal fats and animal plasma lipoproteins.
1 P54317 (/TAS)
Cellular defense response GO:0006968
A defense response that is mediated by cells.
1 P17892 (/IMP)
Phospholipid catabolic process GO:0009395
The chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester.
1 P54317 (/IDA)
Phospholipid catabolic process GO:0009395
The chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester.
1 P17892 (/ISO)
Response to bacterium GO:0009617
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium.
1 P17892 (/IEP)
Post-embryonic development GO:0009791
The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development.
1 P27657 (/IDA)
Post-embryonic development GO:0009791
The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development.
1 Q6P8U6 (/ISO)
Galactolipid catabolic process GO:0019376
The chemical reactions and pathways resulting in the breakdown of galactolipids, any glycolipid containing one of more residues of galactose and/or N-acetylgalactosamine.
1 P17892 (/ISO)
Intestinal cholesterol absorption GO:0030299
Uptake of cholesterol into the blood by absorption from the small intestine.
1 Q6P8U6 (/IMP)
Pancreas development GO:0031016
The process whose specific outcome is the progression of the pancreas over time, from its formation to the mature structure. The pancreas is an endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating enzymes.
1 P54316 (/IEP)
Response to food GO:0032094
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a food stimulus; food is anything which, when taken into the body, serves to nourish or build up the tissues or to supply body heat.
1 P54318 (/IEP)
Intestinal lipid catabolic process GO:0044258
The chemical reactions and pathways resulting in the breakdown into fatty acids and monoglycerides of lipids in the small intestine. Lipids are broken down by lipases released by the pancreas.
1 P17892 (/IMP)
Positive regulation of triglyceride lipase activity GO:0061365
Any process that increases the activity of triglyceride lipase.
1 P16233 (/IDA)
Positive regulation of triglyceride lipase activity GO:0061365
Any process that increases the activity of triglyceride lipase.
1 Q6P8U6 (/ISO)

There are 7 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
5 P16233 (/IDA) P27657 (/IDA) P54316 (/IDA) P54317 (/IDA) P54318 (/IDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
4 A5PK46 (/ISS) P17892 (/ISS) P81139 (/ISS) Q64424 (/ISS)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
3 P16233 (/TAS) P54315 (/TAS) P54317 (/TAS)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
3 P17892 (/ISO) Q5BKQ4 (/ISO) Q6P8U6 (/ISO)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
2 A0MBZ6 (/IMP) G1NFD3 (/IMP)
Zymogen granule membrane GO:0042589
The lipid bilayer surrounding a zymogen granule.
1 P54318 (/IDA)
Zymogen granule membrane GO:0042589
The lipid bilayer surrounding a zymogen granule.
1 P17892 (/ISO)