The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
von Hippel-Lindau disease tumour suppressor, beta domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 3: Protein Vhl

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 1 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 Q9V3C1 (/IPI) Q9V3C1 (/IPI)

There are 11 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein export from nucleus GO:0006611
The directed movement of a protein from the nucleus into the cytoplasm.
2 Q9V3C1 (/IMP) Q9V3C1 (/IMP)
Negative regulation of microtubule depolymerization GO:0007026
Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule depolymerization; prevention of depolymerization of a microtubule can result from binding by 'capping' at the plus end (e.g. by interaction with another cellular protein of structure) or by exposing microtubules to a stabilizing drug such as taxol.
2 Q9V3C1 (/IMP) Q9V3C1 (/IMP)
Centrosome cycle GO:0007098
The cell cycle process in which centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle.
2 Q9V3C1 (/IGI) Q9V3C1 (/IGI)
Open tracheal system development GO:0007424
The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster.
2 Q9V3C1 (/IMP) Q9V3C1 (/IMP)
Epithelial cell migration, open tracheal system GO:0007427
The orderly movement of epithelial cells during development of an open tracheal system. An example of this is found in Drosophila melanogaster.
2 Q9V3C1 (/IMP) Q9V3C1 (/IMP)
Establishment or maintenance of polarity of follicular epithelium GO:0016334
Any cellular process that results in the specification, formation or maintenance of a polarized follicular epithelial sheet.
2 Q9V3C1 (/IMP) Q9V3C1 (/IMP)
Protein ubiquitination GO:0016567
The process in which one or more ubiquitin groups are added to a protein.
2 Q9V3C1 (/IDA) Q9V3C1 (/IDA)
Lumen formation, open tracheal system GO:0035149
Creation of the central hole of a tube in an open tracheal system through which gases flow.
2 Q9V3C1 (/IMP) Q9V3C1 (/IMP)
Trachea development GO:0060438
The process whose specific outcome is the progression of a trachea over time, from its formation to the mature structure. The trachea is the portion of the airway that attaches to the bronchi as it branches.
2 Q9V3C1 (/IMP) Q9V3C1 (/IMP)
Mitotic spindle assembly GO:0090307
The aggregation, arrangement and bonding together of a set of components to form the spindle that contributes to the process of mitosis.
2 Q9V3C1 (/IGI) Q9V3C1 (/IGI)
Regulation of cellular response to hypoxia GO:1900037
Any process that modulates the frequency, rate or extent of cellular response to hypoxia.
2 Q9V3C1 (/IMP) Q9V3C1 (/IMP)

There are 1 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
VCB complex GO:0030891
A protein complex that possesses ubiquitin ligase activity; the complex is usually pentameric; for example, in mammals the subunits are pVHL, elongin B, elongin C, cullin-2 (Cul2), and Rbx1.
2 Q9V3C1 (/IDA) Q9V3C1 (/IDA)