The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Immunoglobulins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 948: Roundabout 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 3 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
4 M9PC46 (/IDA) Q5U176 (/IDA) Q9GPP7 (/IDA) Q9VQ08 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 O44924 (/IPI) Q9W213 (/IPI)
Heparin binding GO:0008201
Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
2 O44924 (/IDA) Q9W213 (/IDA)

There are 31 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
8 M9PC46 (/IMP) O44924 (/IMP) Q5U176 (/IMP) Q9GPP6 (/IMP) Q9GPP7 (/IMP) Q9VPZ7 (/IMP) Q9VQ08 (/IMP) Q9W213 (/IMP)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
8 M9PC46 (/TAS) O44924 (/TAS) Q5U176 (/TAS) Q9GPP6 (/TAS) Q9GPP7 (/TAS) Q9VPZ7 (/TAS) Q9VQ08 (/TAS) Q9W213 (/TAS)
Gonad development GO:0008406
The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones.
8 M9PC46 (/IMP) O44924 (/IMP) Q5U176 (/IMP) Q9GPP6 (/IMP) Q9GPP7 (/IMP) Q9VPZ7 (/IMP) Q9VQ08 (/IMP) Q9W213 (/IMP)
Outflow tract morphogenesis GO:0003151
The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries.
6 M9PC46 (/IGI) O44924 (/IGI) Q5U176 (/IGI) Q9GPP7 (/IGI) Q9VQ08 (/IGI) Q9W213 (/IGI)
Ventral cord development GO:0007419
The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms.
6 M9PC46 (/IMP) Q5U176 (/IMP) Q9GPP6 (/IMP) Q9GPP7 (/IMP) Q9VPZ7 (/IMP) Q9VQ08 (/IMP)
Salivary gland boundary specification GO:0007432
Determination of where the salivary gland forms, the total number of salivary gland cells and how many cells are allocated to each of the specialised cell types within the salivary gland.
6 M9PC46 (/IMP) O44924 (/IMP) Q5U176 (/IMP) Q9GPP7 (/IMP) Q9VQ08 (/IMP) Q9W213 (/IMP)
Mushroom body development GO:0016319
The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells.
6 M9PC46 (/IMP) Q5U176 (/IMP) Q9GPP6 (/IMP) Q9GPP7 (/IMP) Q9VPZ7 (/IMP) Q9VQ08 (/IMP)
Positive regulation of cell-cell adhesion GO:0022409
Any process that activates or increases the rate or extent of cell adhesion to another cell.
6 M9PC46 (/IMP) O44924 (/IMP) Q5U176 (/IMP) Q9GPP7 (/IMP) Q9VQ08 (/IMP) Q9W213 (/IMP)
Embryonic heart tube development GO:0035050
The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure. The heart tube forms as the heart rudiment from the heart field.
6 M9PC46 (/IMP) O44924 (/IMP) Q5U176 (/IMP) Q9GPP7 (/IMP) Q9VQ08 (/IMP) Q9W213 (/IMP)
Central complex development GO:0048036
The process whose specific outcome is the progression of the central complex over time, from its formation to the mature structure. The central complex region of the insect brain is thought to be crucial for control of locomotive behavior. Located in the middle of the two protocerebral hemispheres, it comprises four neuropilar regions, the fan-shaped body, the ellipsoid body, the protocerebral bridge and the paired noduli.
6 M9PC46 (/IMP) Q5U176 (/IMP) Q9GPP6 (/IMP) Q9GPP7 (/IMP) Q9VPZ7 (/IMP) Q9VQ08 (/IMP)
Regulation of epithelial cell migration, open tracheal system GO:2000274
Any process that modulates the frequency, rate or extent of epithelial cell migration, open tracheal system.
6 M9PC46 (/IMP) O44924 (/IMP) Q5U176 (/IMP) Q9GPP7 (/IMP) Q9VQ08 (/IMP) Q9W213 (/IMP)
Neuron migration GO:0001764
The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
4 M9PC46 (/IMP) Q5U176 (/IMP) Q9GPP7 (/IMP) Q9VQ08 (/IMP)
Neuron recognition GO:0008038
The process in which a neuronal cell in a multicellular organism interprets its surroundings.
4 O44924 (/IMP) Q9GPP6 (/IMP) Q9VPZ7 (/IMP) Q9W213 (/IMP)
Synaptic target recognition GO:0008039
The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses.
4 M9PC46 (/IMP) Q5U176 (/IMP) Q9GPP7 (/IMP) Q9VQ08 (/IMP)
Cardioblast cell fate specification GO:0042685
The process in which a cell becomes capable of differentiating autonomously into a cardioblast cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.
4 M9PC46 (/IMP) Q5U176 (/IMP) Q9GPP7 (/IMP) Q9VQ08 (/IMP)
Motor neuron axon guidance GO:0008045
The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues.
2 O44924 (/IMP) Q9W213 (/IMP)
Entrainment of circadian clock GO:0009649
The synchronization of a circadian rhythm to environmental time cues such as light.
2 O44924 (/IDA) Q9W213 (/IDA)
Axon midline choice point recognition GO:0016199
The recognition of molecules at the central nervous system midline choice point by an axon growth cone; this choice point determines whether the growth cone will cross the midline.
2 O44924 (/IGI) Q9W213 (/IGI)
Axon midline choice point recognition GO:0016199
The recognition of molecules at the central nervous system midline choice point by an axon growth cone; this choice point determines whether the growth cone will cross the midline.
2 O44924 (/IMP) Q9W213 (/IMP)
Axon midline choice point recognition GO:0016199
The recognition of molecules at the central nervous system midline choice point by an axon growth cone; this choice point determines whether the growth cone will cross the midline.
2 O44924 (/TAS) Q9W213 (/TAS)
Synaptic target inhibition GO:0016201
The process in which a neuronal cell in a multicellular organism recognizes chemorepellent signals that inhibit its growth toward the source.
2 M9PC46 (/IGI) Q9VPZ7 (/IGI)
Positive regulation of cell migration GO:0030335
Any process that activates or increases the frequency, rate or extent of cell migration.
2 M9PC46 (/IMP) Q9W213 (/IMP)
Roundabout signaling pathway GO:0035385
A series of molecular signals initiated by the binding of a SLIT protein to a Roundabout (ROBO) family receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2 O44924 (/IGI) Q9W213 (/IGI)
Muscle cell cellular homeostasis GO:0046716
The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state.
2 O44924 (/IGI) Q9W213 (/IGI)
Dendrite morphogenesis GO:0048813
The process in which the anatomical structures of a dendrite are generated and organized.
2 O44924 (/IMP) Q9W213 (/IMP)
Dendrite morphogenesis GO:0048813
The process in which the anatomical structures of a dendrite are generated and organized.
2 O44924 (/TAS) Q9W213 (/TAS)
Regulation of dendrite development GO:0050773
Any process that modulates the frequency, rate or extent of dendrite development.
2 O44924 (/IMP) Q9W213 (/IMP)
Dendrite guidance GO:0070983
The process in which the migration of a dendrite is directed to a specific target site in response to a combination of attractive and repulsive cues.
2 O44924 (/IMP) Q9W213 (/IMP)
Photoreceptor cell axon guidance GO:0072499
The chemotaxis process that directs the migration of a photoreceptor cell axon growth cone to its target in the optic lobe in response to a combination of attractive and repulsive cues.
2 O44924 (/IMP) Q9W213 (/IMP)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
1 Q9W213 (/IPI)
Synaptic target inhibition GO:0016201
The process in which a neuronal cell in a multicellular organism recognizes chemorepellent signals that inhibit its growth toward the source.
1 Q9VPZ7 (/IMP)

There are 10 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
8 M9PC46 (/IDA) O44924 (/IDA) Q5U176 (/IDA) Q9GPP6 (/IDA) Q9GPP7 (/IDA) Q9VPZ7 (/IDA) Q9VQ08 (/IDA) Q9W213 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 O44924 (/IDA) Q9VPZ7 (/IDA) Q9W213 (/IDA)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 O44924 (/ISS) Q9W213 (/ISS)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
2 O44924 (/IDA) Q9W213 (/IDA)
Vesicle GO:0031982
Any small, fluid-filled, spherical organelle enclosed by membrane.
2 O44924 (/IDA) Q9W213 (/IDA)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
2 O44924 (/IPI) Q9W213 (/IPI)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
2 O44924 (/IDA) Q9W213 (/IDA)
Axonal growth cone GO:0044295
The migrating motile tip of a growing nerve cell axon.
2 O44924 (/IDA) Q9W213 (/IDA)
Slit-Robo signaling complex GO:0071666
A protein-carbohydrate complex that consists of a transmembrane roundabout (Robo) receptor, an extracellular Slit ligand and heparin/heparan sulfate.
2 O44924 (/IDA) Q9W213 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 O44924 (/TAS)