The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Immunoglobulins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 662: Tyrosine-protein kinase receptor UFO

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 12 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Growth factor binding GO:0019838
Interacting selectively and non-covalently with any growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate.
5 A0A0G2K2H0 (/TAS) E9PSX9 (/TAS) E9PSY0 (/TAS) Q8VI99 (/TAS) Q8VIA0 (/TAS)
Myosin heavy chain binding GO:0032036
Interacting selectively and non-covalently with a heavy chain of a myosin complex.
5 A0A0G2K2H0 (/IPI) E9PSX9 (/IPI) E9PSY0 (/IPI) Q8VI99 (/IPI) Q8VIA0 (/IPI)
Phosphatidylinositol 3-kinase binding GO:0043548
Interacting selectively and non-covalently with a phosphatidylinositol 3-kinase, any enzyme that catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring.
5 A0A0G2K2H0 (/IPI) E9PSX9 (/IPI) E9PSY0 (/IPI) Q8VI99 (/IPI) Q8VIA0 (/IPI)
Phosphatidylserine binding GO:0001786
Interacting selectively and non-covalently with phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine.
1 P30530 (/IDA)
Phosphatidylserine binding GO:0001786
Interacting selectively and non-covalently with phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine.
1 Q00993 (/ISO)
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
1 P30530 (/EXP)
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
1 Q00993 (/ISO)
Transmembrane receptor protein tyrosine kinase activity GO:0004714
Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.
1 P30530 (/TAS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 P30530 (/IPI)
Myosin heavy chain binding GO:0032036
Interacting selectively and non-covalently with a heavy chain of a myosin complex.
1 Q00993 (/ISO)
Phosphatidylinositol 3-kinase binding GO:0043548
Interacting selectively and non-covalently with a phosphatidylinositol 3-kinase, any enzyme that catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring.
1 Q00993 (/ISO)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
1 Q00993 (/IPI)

There are 60 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
6 A0A0G2K2H0 (/IMP) E9PSX9 (/IMP) E9PSY0 (/IMP) Q00993 (/IMP) Q8VI99 (/IMP) Q8VIA0 (/IMP)
Cell differentiation GO:0030154
The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
5 A0A0G2K2H0 (/IMP) E9PSX9 (/IMP) E9PSY0 (/IMP) Q8VI99 (/IMP) Q8VIA0 (/IMP)
Animal organ regeneration GO:0031100
The regrowth of a lost or destroyed animal organ.
5 A0A0G2K2H0 (/IEP) E9PSX9 (/IEP) E9PSY0 (/IEP) Q8VI99 (/IEP) Q8VIA0 (/IEP)
Tissue regeneration GO:0042246
The regrowth of lost or destroyed tissues.
5 A0A0G2K2H0 (/TAS) E9PSX9 (/TAS) E9PSY0 (/TAS) Q8VI99 (/TAS) Q8VIA0 (/TAS)
Tissue remodeling GO:0048771
The reorganization or renovation of existing tissues. This process can either change the characteristics of a tissue such as in blood vessel remodeling, or result in the dynamic equilibrium of a tissue such as in bone remodeling.
5 A0A0G2K2H0 (/TAS) E9PSX9 (/TAS) E9PSY0 (/TAS) Q8VI99 (/TAS) Q8VIA0 (/TAS)
Cellular response to hydrogen peroxide GO:0070301
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
5 A0A0G2K2H0 (/IDA) E9PSX9 (/IDA) E9PSY0 (/IDA) Q8VI99 (/IDA) Q8VIA0 (/IDA)
Neuron migration GO:0001764
The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
1 Q00993 (/IGI)
Neuron migration GO:0001764
The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
1 Q00993 (/IMP)
Natural killer cell differentiation GO:0001779
The process in which a relatively unspecialized cell acquires the specialized features of a natural killer cell.
1 Q00993 (/IGI)
Negative regulation of cytokine production GO:0001818
Any process that stops, prevents, or reduces the rate of production of a cytokine.
1 Q00993 (/IGI)
Positive regulation of cytokine-mediated signaling pathway GO:0001961
Any process that activates or increases the frequency, rate or extent of a cytokine mediated signaling pathway.
1 P30530 (/IDA)
Positive regulation of cytokine-mediated signaling pathway GO:0001961
Any process that activates or increases the frequency, rate or extent of a cytokine mediated signaling pathway.
1 Q00993 (/ISO)
Blood vessel remodeling GO:0001974
The reorganization or renovation of existing blood vessels.
1 Q00993 (/IMP)
Phagocytosis GO:0006909
A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.
1 P30530 (/IDA)
Phagocytosis GO:0006909
A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.
1 Q00993 (/IGI)
Phagocytosis GO:0006909
A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.
1 Q00993 (/ISO)
Inflammatory response GO:0006954
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
1 Q00993 (/IMP)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
1 P30530 (/TAS)
Enzyme linked receptor protein signaling pathway GO:0007167
Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell, where the receptor possesses catalytic activity or is closely associated with an enzyme such as a protein kinase, and ending with regulation of a downstream cellular process, e.g. transcription.
1 Q00993 (/IGI)
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
1 Q00993 (/IGI)
Forebrain cell migration GO:0021885
The orderly movement of a cell from one site to another at least one of which is located in the forebrain.
1 Q00993 (/IGI)
Cell differentiation GO:0030154
The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
1 Q00993 (/ISO)
Platelet activation GO:0030168
A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug.
1 Q00993 (/IMP)
Cellular response to extracellular stimulus GO:0031668
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus.
1 Q00993 (/IDA)
Negative regulation of interferon-gamma production GO:0032689
Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.
1 P30530 (/IDA)
Negative regulation of interferon-gamma production GO:0032689
Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.
1 Q00993 (/ISO)
Negative regulation of tumor necrosis factor production GO:0032720
Any process that stops, prevents, or reduces the frequency, rate, or extent of tumor necrosis factor production.
1 Q00993 (/IGI)
Positive regulation of natural killer cell differentiation GO:0032825
Any process that activates or increases the frequency, rate or extent of natural killer cell differentiation.
1 P30530 (/IDA)
Positive regulation of natural killer cell differentiation GO:0032825
Any process that activates or increases the frequency, rate or extent of natural killer cell differentiation.
1 Q00993 (/ISO)
Secretion by cell GO:0032940
The controlled release of a substance by a cell.
1 Q00993 (/IMP)
Erythrocyte homeostasis GO:0034101
Any process of regulating the production and elimination of erythrocytes within an organism.
1 Q00993 (/IGI)
Erythrocyte homeostasis GO:0034101
Any process of regulating the production and elimination of erythrocytes within an organism.
1 Q00993 (/IMP)
Substrate adhesion-dependent cell spreading GO:0034446
The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate.
1 Q00993 (/IMP)
Cellular response to interferon-alpha GO:0035457
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-alpha stimulus. Interferon-alpha is a type I interferon.
1 P30530 (/IDA)
Cellular response to interferon-alpha GO:0035457
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-alpha stimulus. Interferon-alpha is a type I interferon.
1 Q00993 (/ISO)
Ovulation cycle GO:0042698
The type of sexual cycle seen in females, often with physiologic changes in the endometrium that recur at regular intervals during the reproductive years.
1 Q00993 (/IGI)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
1 Q00993 (/IGI)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
1 Q00993 (/ISO)
Apoptotic cell clearance GO:0043277
The recognition and removal of an apoptotic cell by a neighboring cell or by a phagocyte.
1 Q00993 (/IGI)
Apoptotic cell clearance GO:0043277
The recognition and removal of an apoptotic cell by a neighboring cell or by a phagocyte.
1 Q00993 (/IMP)
Protein kinase B signaling GO:0043491
A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase B (also called AKT), which occurs as a result of a single trigger reaction or compound.
1 Q00993 (/IGI)
Protein kinase B signaling GO:0043491
A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase B (also called AKT), which occurs as a result of a single trigger reaction or compound.
1 Q00993 (/IMP)
Negative regulation of neuron apoptotic process GO:0043524
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.
1 Q00993 (/IGI)
Negative regulation of neuron apoptotic process GO:0043524
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.
1 Q00993 (/IMP)
Viral entry into host cell GO:0046718
The process that occurs after viral attachment by which a virus, or viral nucleic acid, breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the viral nucleic acid is released into the host cell cytoplasm.
1 P30530 (/IMP)
Viral entry into host cell GO:0046718
The process that occurs after viral attachment by which a virus, or viral nucleic acid, breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the viral nucleic acid is released into the host cell cytoplasm.
1 Q00993 (/ISO)
Vascular endothelial growth factor receptor signaling pathway GO:0048010
Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor (VEGFR) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 P30530 (/TAS)
Cell maturation GO:0048469
A developmental process, independent of morphogenetic (shape) change, that is required for a cell to attain its fully functional state.
1 P30530 (/IEP)
Positive regulation of pinocytosis GO:0048549
Any process that activates, maintains or increases the rate of pinocytosis. Pinocytosis is the process in which cells take in liquid material from their external environment; literally 'cell drinking'. Liquid is enclosed in vesicles, formed by invagination of the plasma membrane. These vesicles then move into the cell and pass their contents to endosomes.
1 P30530 (/IMP)
Positive regulation of pinocytosis GO:0048549
Any process that activates, maintains or increases the rate of pinocytosis. Pinocytosis is the process in which cells take in liquid material from their external environment; literally 'cell drinking'. Liquid is enclosed in vesicles, formed by invagination of the plasma membrane. These vesicles then move into the cell and pass their contents to endosomes.
1 Q00993 (/ISO)
Negative regulation of lymphocyte activation GO:0051250
Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte activation.
1 Q00993 (/IGI)
Positive regulation of protein kinase B signaling GO:0051897
Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
1 Q00993 (/IMP)
Vagina development GO:0060068
The reproductive developmental process whose specific outcome is the progression of the vagina over time, from its formation to the mature structure.
1 Q00993 (/IGI)
Cellular response to hydrogen peroxide GO:0070301
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
1 Q00993 (/ISO)
Cellular response to lipopolysaccharide GO:0071222
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
1 P30530 (/IDA)
Cellular response to lipopolysaccharide GO:0071222
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
1 Q00993 (/ISO)
Dendritic cell differentiation GO:0097028
The process in which a precursor cell type acquires the specialized features of a dendritic cell. A dendritic cell is a leukocyte of dendritic lineage specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation.
1 P30530 (/IEP)
Neutrophil clearance GO:0097350
The selective elimination of senescent neutrophils from the body by autoregulatory mechanisms.
1 Q00993 (/IGI)
Negative regulation of dendritic cell apoptotic process GO:2000669
Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell apoptotic process.
1 P30530 (/IDA)
Negative regulation of dendritic cell apoptotic process GO:2000669
Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell apoptotic process.
1 Q00993 (/ISO)

There are 10 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 P30530 (/IDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 Q00993 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P30530 (/TAS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 P30530 (/TAS)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
1 P30530 (/HDA)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
1 P30530 (/IDA)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
1 Q00993 (/ISO)
Host cell surface GO:0044228
The external part of the host cell wall and/or host plasma membrane.
1 P30530 (/IDA)
Host cell surface GO:0044228
The external part of the host cell wall and/or host plasma membrane.
1 Q00993 (/ISO)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 P30530 (/HDA)
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