The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 24: afadin isoform X2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 3 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
9 A0A0B4KF82 (/IPI) A0A0B4KFK9 (/IPI) A0A0B4KG43 (/IPI) A0A0B4KGI6 (/IPI) Q24279 (/IPI) Q8IPP3 (/IPI) Q8IPP4 (/IPI) Q95TT5 (/IPI) Q9VN82 (/IPI)
Ras GTPase binding GO:0017016
Interacting selectively and non-covalently with any member of the Ras superfamily of monomeric GTPases.
9 A0A0B4KF82 (/IPI) A0A0B4KFK9 (/IPI) A0A0B4KG43 (/IPI) A0A0B4KGI6 (/IPI) Q24279 (/IPI) Q8IPP3 (/IPI) Q8IPP4 (/IPI) Q95TT5 (/IPI) Q9VN82 (/IPI)
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
9 A0A0B4KF82 (/IPI) A0A0B4KFK9 (/IPI) A0A0B4KG43 (/IPI) A0A0B4KGI6 (/IPI) Q24279 (/IPI) Q8IPP3 (/IPI) Q8IPP4 (/IPI) Q95TT5 (/IPI) Q9VN82 (/IPI)

There are 18 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Establishment of mitotic spindle orientation GO:0000132
A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures.
9 A0A0B4KF82 (/IGI) A0A0B4KFK9 (/IGI) A0A0B4KG43 (/IGI) A0A0B4KGI6 (/IGI) Q24279 (/IGI) Q8IPP3 (/IGI) Q8IPP4 (/IGI) Q95TT5 (/IGI) Q9VN82 (/IGI)
Establishment of mitotic spindle orientation GO:0000132
A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures.
9 A0A0B4KF82 (/IMP) A0A0B4KFK9 (/IMP) A0A0B4KG43 (/IMP) A0A0B4KGI6 (/IMP) Q24279 (/IMP) Q8IPP3 (/IMP) Q8IPP4 (/IMP) Q95TT5 (/IMP) Q9VN82 (/IMP)
Establishment or maintenance of cell polarity GO:0007163
Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns.
9 A0A0B4KF82 (/NAS) A0A0B4KFK9 (/NAS) A0A0B4KG43 (/NAS) A0A0B4KGI6 (/NAS) Q24279 (/NAS) Q8IPP3 (/NAS) Q8IPP4 (/NAS) Q95TT5 (/NAS) Q9VN82 (/NAS)
Dorsal closure GO:0007391
The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally.
9 A0A0B4KF82 (/IGI) A0A0B4KFK9 (/IGI) A0A0B4KG43 (/IGI) A0A0B4KGI6 (/IGI) Q24279 (/IGI) Q8IPP3 (/IGI) Q8IPP4 (/IGI) Q95TT5 (/IGI) Q9VN82 (/IGI)
Dorsal closure GO:0007391
The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally.
9 A0A0B4KF82 (/IMP) A0A0B4KFK9 (/IMP) A0A0B4KG43 (/IMP) A0A0B4KGI6 (/IMP) Q24279 (/IMP) Q8IPP3 (/IMP) Q8IPP4 (/IMP) Q95TT5 (/IMP) Q9VN82 (/IMP)
Dorsal closure GO:0007391
The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally.
9 A0A0B4KF82 (/TAS) A0A0B4KFK9 (/TAS) A0A0B4KG43 (/TAS) A0A0B4KGI6 (/TAS) Q24279 (/TAS) Q8IPP3 (/TAS) Q8IPP4 (/TAS) Q95TT5 (/TAS) Q9VN82 (/TAS)
Dorsal closure, elongation of leading edge cells GO:0007394
The change in shape of cells at the dorsal-most (leading) edge of the epidermis from being polygonal to being elongated in the dorsal/ventral axis.
9 A0A0B4KF82 (/NAS) A0A0B4KFK9 (/NAS) A0A0B4KG43 (/NAS) A0A0B4KGI6 (/NAS) Q24279 (/NAS) Q8IPP3 (/NAS) Q8IPP4 (/NAS) Q95TT5 (/NAS) Q9VN82 (/NAS)
Glial cell proliferation GO:0014009
The multiplication or reproduction of glial cells by cell division, resulting in the expansion of their population. Glial cells exist throughout the nervous system, and include Schwann cells, astrocytes, and oligodendrocytes among others.
9 A0A0B4KF82 (/IMP) A0A0B4KFK9 (/IMP) A0A0B4KG43 (/IMP) A0A0B4KGI6 (/IMP) Q24279 (/IMP) Q8IPP3 (/IMP) Q8IPP4 (/IMP) Q95TT5 (/IMP) Q9VN82 (/IMP)
Second mitotic wave involved in compound eye morphogenesis GO:0016330
A discrete cell cycle in the third instar eye imaginal disc after progression of the morphogenetic furrow that contributes to compound eye morphogenesis. It is essential for generation of a sufficient pool of uncommitted cells to develop complete ommatidia.
9 A0A0B4KF82 (/IMP) A0A0B4KFK9 (/IMP) A0A0B4KG43 (/IMP) A0A0B4KGI6 (/IMP) Q24279 (/IMP) Q8IPP3 (/IMP) Q8IPP4 (/IMP) Q95TT5 (/IMP) Q9VN82 (/IMP)
Regulation of protein localization GO:0032880
Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location.
9 A0A0B4KF82 (/IDA) A0A0B4KFK9 (/IDA) A0A0B4KG43 (/IDA) A0A0B4KGI6 (/IDA) Q24279 (/IDA) Q8IPP3 (/IDA) Q8IPP4 (/IDA) Q95TT5 (/IDA) Q9VN82 (/IDA)
Regulation of protein localization GO:0032880
Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location.
9 A0A0B4KF82 (/IMP) A0A0B4KFK9 (/IMP) A0A0B4KG43 (/IMP) A0A0B4KGI6 (/IMP) Q24279 (/IMP) Q8IPP3 (/IMP) Q8IPP4 (/IMP) Q95TT5 (/IMP) Q9VN82 (/IMP)
Regulation of JNK cascade GO:0046328
Any process that modulates the frequency, rate or extent of signal transduction mediated by the JNK cascade.
9 A0A0B4KF82 (/IGI) A0A0B4KFK9 (/IGI) A0A0B4KG43 (/IGI) A0A0B4KGI6 (/IGI) Q24279 (/IGI) Q8IPP3 (/IGI) Q8IPP4 (/IGI) Q95TT5 (/IGI) Q9VN82 (/IGI)
Regulation of JNK cascade GO:0046328
Any process that modulates the frequency, rate or extent of signal transduction mediated by the JNK cascade.
9 A0A0B4KF82 (/IMP) A0A0B4KFK9 (/IMP) A0A0B4KG43 (/IMP) A0A0B4KGI6 (/IMP) Q24279 (/IMP) Q8IPP3 (/IMP) Q8IPP4 (/IMP) Q95TT5 (/IMP) Q9VN82 (/IMP)
Regulation of JNK cascade GO:0046328
Any process that modulates the frequency, rate or extent of signal transduction mediated by the JNK cascade.
9 A0A0B4KF82 (/NAS) A0A0B4KFK9 (/NAS) A0A0B4KG43 (/NAS) A0A0B4KGI6 (/NAS) Q24279 (/NAS) Q8IPP3 (/NAS) Q8IPP4 (/NAS) Q95TT5 (/NAS) Q9VN82 (/NAS)
Embryonic morphogenesis GO:0048598
The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants.
9 A0A0B4KF82 (/IMP) A0A0B4KFK9 (/IMP) A0A0B4KG43 (/IMP) A0A0B4KGI6 (/IMP) Q24279 (/IMP) Q8IPP3 (/IMP) Q8IPP4 (/IMP) Q95TT5 (/IMP) Q9VN82 (/IMP)
Epidermis morphogenesis GO:0048730
The process in which the anatomical structures of the epidermis are generated and organized. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species.
9 A0A0B4KF82 (/IMP) A0A0B4KFK9 (/IMP) A0A0B4KG43 (/IMP) A0A0B4KGI6 (/IMP) Q24279 (/IMP) Q8IPP3 (/IMP) Q8IPP4 (/IMP) Q95TT5 (/IMP) Q9VN82 (/IMP)
Compound eye development GO:0048749
The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye.
9 A0A0B4KF82 (/IGI) A0A0B4KFK9 (/IGI) A0A0B4KG43 (/IGI) A0A0B4KGI6 (/IGI) Q24279 (/IGI) Q8IPP3 (/IGI) Q8IPP4 (/IGI) Q95TT5 (/IGI) Q9VN82 (/IGI)
Ommatidial rotation GO:0016318
The process in which photoreceptors are arranged in ommatidia in the dorsal and ventral fields to be mirror images. The polarity is established in the imaginal discs concurrently with cell fate specification.
1 Q9VN82 (/IMP)

There are 7 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Adherens junction GO:0005912
A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments.
9 A0A0B4KF82 (/IDA) A0A0B4KFK9 (/IDA) A0A0B4KG43 (/IDA) A0A0B4KGI6 (/IDA) Q24279 (/IDA) Q8IPP3 (/IDA) Q8IPP4 (/IDA) Q95TT5 (/IDA) Q9VN82 (/IDA)
Adherens junction GO:0005912
A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments.
9 A0A0B4KF82 (/NAS) A0A0B4KFK9 (/NAS) A0A0B4KG43 (/NAS) A0A0B4KGI6 (/NAS) Q24279 (/NAS) Q8IPP3 (/NAS) Q8IPP4 (/NAS) Q95TT5 (/NAS) Q9VN82 (/NAS)
Adherens junction GO:0005912
A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments.
9 A0A0B4KF82 (/TAS) A0A0B4KFK9 (/TAS) A0A0B4KG43 (/TAS) A0A0B4KGI6 (/TAS) Q24279 (/TAS) Q8IPP3 (/TAS) Q8IPP4 (/TAS) Q95TT5 (/TAS) Q9VN82 (/TAS)
Zonula adherens GO:0005915
A cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells.
9 A0A0B4KF82 (/TAS) A0A0B4KFK9 (/TAS) A0A0B4KG43 (/TAS) A0A0B4KGI6 (/TAS) Q24279 (/TAS) Q8IPP3 (/TAS) Q8IPP4 (/TAS) Q95TT5 (/TAS) Q9VN82 (/TAS)
Connecting hemi-adherens junction GO:0005926
A cell-substrate adherens junction, also known as a hemiadherens junction (HAJ) that forms one of a pair of junctions in opposing cells that are separated by only 30-40nm, with a thin line of extracellular electron-dense material in between; found where muscles attach to epidermal cells directly (in insects).
9 A0A0B4KF82 (/IDA) A0A0B4KFK9 (/IDA) A0A0B4KG43 (/IDA) A0A0B4KGI6 (/IDA) Q24279 (/IDA) Q8IPP3 (/IDA) Q8IPP4 (/IDA) Q95TT5 (/IDA) Q9VN82 (/IDA)
Cell cortex GO:0005938
The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
9 A0A0B4KF82 (/HDA) A0A0B4KFK9 (/HDA) A0A0B4KG43 (/HDA) A0A0B4KGI6 (/HDA) Q24279 (/HDA) Q8IPP3 (/HDA) Q8IPP4 (/HDA) Q95TT5 (/HDA) Q9VN82 (/HDA)
Cell cortex GO:0005938
The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
9 A0A0B4KF82 (/IDA) A0A0B4KFK9 (/IDA) A0A0B4KG43 (/IDA) A0A0B4KGI6 (/IDA) Q24279 (/IDA) Q8IPP3 (/IDA) Q8IPP4 (/IDA) Q95TT5 (/IDA) Q9VN82 (/IDA)