The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Nucleic acid-binding proteins
".
FunFam 64: Replication protein A subunit
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 19 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
13 |
P22336 (/IPI)
P22336 (/IPI)
P22336 (/IPI)
P27694 (/IPI)
Q10Q08 (/IPI)
Q10Q08 (/IPI)
Q10Q08 (/IPI)
Q10Q08 (/IPI)
Q19537 (/IPI)
Q65XV7 (/IPI)
(3 more) |
Single-stranded DNA binding GO:0003697
Interacting selectively and non-covalently with single-stranded DNA.
|
9 | Q01588 (/ISS) Q19537 (/ISS) Q23696 (/ISS) Q5FW17 (/ISS) Q5FW17 (/ISS) Q5R7Q4 (/ISS) Q5ZJJ2 (/ISS) Q6NY74 (/ISS) Q8VEE4 (/ISS) |
Damaged DNA binding GO:0003684
Interacting selectively and non-covalently with damaged DNA.
|
7 | Q01588 (/ISS) Q5FW17 (/ISS) Q5FW17 (/ISS) Q5R7Q4 (/ISS) Q5ZJJ2 (/ISS) Q6NY74 (/ISS) Q8VEE4 (/ISS) |
Single-stranded DNA binding GO:0003697
Interacting selectively and non-covalently with single-stranded DNA.
|
7 | A0A0G2KAT3 (/IDA) P22336 (/IDA) P22336 (/IDA) P22336 (/IDA) P27694 (/IDA) Q24492 (/IDA) Q7TP21 (/IDA) |
Damaged DNA binding GO:0003684
Interacting selectively and non-covalently with damaged DNA.
|
5 | Q384B5 (/ISO) Q384B5 (/ISO) Q384B5 (/ISO) Q384B5 (/ISO) Q8VEE4 (/ISO) |
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
|
4 | P22336 (/IDA) P22336 (/IDA) P22336 (/IDA) Q54HE3 (/IDA) |
Double-stranded DNA binding GO:0003690
Interacting selectively and non-covalently with double-stranded DNA.
|
3 | P22336 (/IDA) P22336 (/IDA) P22336 (/IDA) |
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
|
3 | P22336 (/HDA) P22336 (/HDA) P22336 (/HDA) |
Damaged DNA binding GO:0003684
Interacting selectively and non-covalently with damaged DNA.
|
2 | P27694 (/IDA) Q4Q884 (/IDA) |
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
|
1 | Q8VEE4 (/IDA) |
Showing 1 to 10 of 19 entries
There are 86 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
DNA replication GO:0006260
The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
|
11 |
Q01588 (/ISS)
Q19537 (/ISS)
Q23696 (/ISS)
Q24492 (/ISS)
Q5FW17 (/ISS)
Q5FW17 (/ISS)
Q5R7Q4 (/ISS)
Q5ZJJ2 (/ISS)
Q6NY74 (/ISS)
Q8VEE4 (/ISS)
(1 more) |
DNA repair GO:0006281
The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
|
7 | P22336 (/IMP) P22336 (/IMP) P22336 (/IMP) P27694 (/IMP) Q6YZ49 (/IMP) Q6YZ49 (/IMP) Q92372 (/IMP) |
Protein localization to chromosome GO:0034502
Any process in which a protein is transported to, or maintained at, a specific location on a chromosome.
|
7 | Q01588 (/ISS) Q5FW17 (/ISS) Q5FW17 (/ISS) Q5R7Q4 (/ISS) Q5ZJJ2 (/ISS) Q6NY74 (/ISS) Q8VEE4 (/ISS) |
Cellular response to DNA damage stimulus GO:0006974
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
|
6 | Q384B5 (/ISO) Q384B5 (/ISO) Q384B5 (/ISO) Q384B5 (/ISO) Q4Q884 (/ISO) Q8VEE4 (/ISO) |
DNA replication GO:0006260
The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
|
4 | P22336 (/IMP) P22336 (/IMP) P22336 (/IMP) P27694 (/IMP) |
Telomere maintenance via recombination GO:0000722
Any recombinational process that contributes to the maintenance of proper telomeric length.
|
3 | P22336 (/IGI) P22336 (/IGI) P22336 (/IGI) |
Double-strand break repair via homologous recombination GO:0000724
The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule.
|
3 | P22336 (/IGI) P22336 (/IGI) P22336 (/IGI) |
DNA topological change GO:0006265
The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.
|
3 | P22336 (/IDA) P22336 (/IDA) P22336 (/IDA) |
DNA unwinding involved in DNA replication GO:0006268
The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication.
|
3 | P22336 (/IDA) P22336 (/IDA) P22336 (/IDA) |
DNA repair GO:0006281
The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
|
3 | Q5ZJJ2 (/TAS) Q9SD82 (/TAS) Q9SD82 (/TAS) |
Showing 1 to 10 of 86 entries
There are 33 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
DNA replication factor A complex GO:0005662
A conserved heterotrimeric complex that binds nonspecifically to single-stranded DNA and is required for multiple processes in eukaryotic DNA metabolism, including DNA replication, DNA repair, and recombination. In all eukaryotic organisms examined the complex is composed of subunits of approximately 70, 30, and 14 kDa.
|
12 |
A0A0G2KAT3 (/IDA)
P22336 (/IDA)
P22336 (/IDA)
P22336 (/IDA)
P27694 (/IDA)
Q10Q08 (/IDA)
Q10Q08 (/IDA)
Q10Q08 (/IDA)
Q10Q08 (/IDA)
Q24492 (/IDA)
(2 more) |
DNA replication factor A complex GO:0005662
A conserved heterotrimeric complex that binds nonspecifically to single-stranded DNA and is required for multiple processes in eukaryotic DNA metabolism, including DNA replication, DNA repair, and recombination. In all eukaryotic organisms examined the complex is composed of subunits of approximately 70, 30, and 14 kDa.
|
9 | Q01588 (/ISS) Q19537 (/ISS) Q23696 (/ISS) Q5FW17 (/ISS) Q5FW17 (/ISS) Q5R7Q4 (/ISS) Q5ZJJ2 (/ISS) Q6NY74 (/ISS) Q8VEE4 (/ISS) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
7 | P22336 (/IDA) P22336 (/IDA) P22336 (/IDA) P27694 (/IDA) Q19537 (/IDA) Q24492 (/IDA) Q8VEE4 (/IDA) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
7 | Q01588 (/ISS) Q23696 (/ISS) Q5FW17 (/ISS) Q5FW17 (/ISS) Q5R7Q4 (/ISS) Q5ZJJ2 (/ISS) Q6NY74 (/ISS) |
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
6 | P27694 (/IDA) Q19537 (/IDA) Q384B5 (/IDA) Q384B5 (/IDA) Q384B5 (/IDA) Q384B5 (/IDA) |
Nuclear chromosome, telomeric region GO:0000784
The terminal region of a linear nuclear chromosome that includes the telomeric DNA repeats and associated proteins.
|
5 | Q384B5 (/ISO) Q384B5 (/ISO) Q384B5 (/ISO) Q384B5 (/ISO) Q4Q884 (/ISO) |
Condensed nuclear chromosome GO:0000794
A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct nuclear chromosome.
|
4 | P22336 (/IDA) P22336 (/IDA) P22336 (/IDA) Q8VEE4 (/IDA) |
Nuclear periphery GO:0034399
The portion of the nuclear lumen proximal to the inner nuclear membrane.
|
4 | Q384B5 (/ISO) Q384B5 (/ISO) Q384B5 (/ISO) Q384B5 (/ISO) |
Chromosome, telomeric region GO:0000781
The terminal region of a linear chromosome that includes the telomeric DNA repeats and associated proteins.
|
3 | P22336 (/IMP) P22336 (/IMP) P22336 (/IMP) |
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
3 | P27694 (/TAS) Q5ZJJ2 (/TAS) Q8VEE4 (/TAS) |
Showing 1 to 10 of 33 entries