The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Nucleic acid-binding proteins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 44: 26S protease regulatory subunit 8

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 22 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
196 P62194 (/ISS) P62194 (/ISS) P62194 (/ISS) P62194 (/ISS) P62194 (/ISS) P62194 (/ISS) P62194 (/ISS) P62194 (/ISS) P62194 (/ISS) P62194 (/ISS)
(186 more)
Thyrotropin-releasing hormone receptor binding GO:0031531
Interacting selectively and non-covalently with a receptor for thyrotropin-releasing hormone, a tripeptide hormone that is produced by the hypothalamus and stimulates the release of thyroid-stimulating hormone (TSH) and prolactin by the anterior pituitary.
196 P62194 (/ISS) P62194 (/ISS) P62194 (/ISS) P62194 (/ISS) P62194 (/ISS) P62194 (/ISS) P62194 (/ISS) P62194 (/ISS) P62194 (/ISS) P62194 (/ISS)
(186 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
106 O18413 (/IPI) P62195 (/IPI) P62195 (/IPI) P62195 (/IPI) P62195 (/IPI) P62195 (/IPI) P62195 (/IPI) P62195 (/IPI) P62195 (/IPI) P62195 (/IPI)
(96 more)
ATPase activity GO:0016887
Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.
74 P62195 (/ISS) P62195 (/ISS) P62195 (/ISS) P62195 (/ISS) P62195 (/ISS) P62195 (/ISS) P62195 (/ISS) P62195 (/ISS) P62195 (/ISS) P62195 (/ISS)
(64 more)
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
48 P62196 (/IPI) P62196 (/IPI) P62196 (/IPI) P62196 (/IPI) P62196 (/IPI) P62196 (/IPI) P62196 (/IPI) P62196 (/IPI) P62196 (/IPI) P62196 (/IPI)
(38 more)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
48 P62195 (/IDA) P62195 (/IDA) P62195 (/IDA) P62195 (/IDA) P62195 (/IDA) P62195 (/IDA) P62195 (/IDA) P62195 (/IDA) P62195 (/IDA) P62195 (/IDA)
(38 more)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
48 P62195 (/IPI) P62195 (/IPI) P62195 (/IPI) P62195 (/IPI) P62195 (/IPI) P62195 (/IPI) P62195 (/IPI) P62195 (/IPI) P62195 (/IPI) P62195 (/IPI)
(38 more)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
48 P62196 (/ISA) P62196 (/ISA) P62196 (/ISA) P62196 (/ISA) P62196 (/ISA) P62196 (/ISA) P62196 (/ISA) P62196 (/ISA) P62196 (/ISA) P62196 (/ISA)
(38 more)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
48 P62196 (/ISO) P62196 (/ISO) P62196 (/ISO) P62196 (/ISO) P62196 (/ISO) P62196 (/ISO) P62196 (/ISO) P62196 (/ISO) P62196 (/ISO) P62196 (/ISO)
(38 more)
ATPase activity GO:0016887
Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.
48 P62198 (/IDA) P62198 (/IDA) P62198 (/IDA) P62198 (/IDA) P62198 (/IDA) P62198 (/IDA) P62198 (/IDA) P62198 (/IDA) P62198 (/IDA) P62198 (/IDA)
(38 more)
Showing 1 to 10 of 22 entries

There are 54 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
197 P62194 (/ISS) P62194 (/ISS) P62194 (/ISS) P62194 (/ISS) P62194 (/ISS) P62194 (/ISS) P62194 (/ISS) P62194 (/ISS) P62194 (/ISS) P62194 (/ISS)
(187 more)
MAPK cascade GO:0000165
An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
48 P62195 (/TAS) P62195 (/TAS) P62195 (/TAS) P62195 (/TAS) P62195 (/TAS) P62195 (/TAS) P62195 (/TAS) P62195 (/TAS) P62195 (/TAS) P62195 (/TAS)
(38 more)
Protein polyubiquitination GO:0000209
Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain.
48 P62195 (/TAS) P62195 (/TAS) P62195 (/TAS) P62195 (/TAS) P62195 (/TAS) P62195 (/TAS) P62195 (/TAS) P62195 (/TAS) P62195 (/TAS) P62195 (/TAS)
(38 more)
Stimulatory C-type lectin receptor signaling pathway GO:0002223
Any series of molecular signals generated as a consequence of binding to a C-type lectin receptor capable of cellular activation.
48 P62195 (/TAS) P62195 (/TAS) P62195 (/TAS) P62195 (/TAS) P62195 (/TAS) P62195 (/TAS) P62195 (/TAS) P62195 (/TAS) P62195 (/TAS) P62195 (/TAS)
(38 more)
Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479
The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class I molecule. Class I here refers to classical class I molecules.
48 P62195 (/TAS) P62195 (/TAS) P62195 (/TAS) P62195 (/TAS) P62195 (/TAS) P62195 (/TAS) P62195 (/TAS) P62195 (/TAS) P62195 (/TAS) P62195 (/TAS)
(38 more)
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
48 P62195 (/IDA) P62195 (/IDA) P62195 (/IDA) P62195 (/IDA) P62195 (/IDA) P62195 (/IDA) P62195 (/IDA) P62195 (/IDA) P62195 (/IDA) P62195 (/IDA)
(38 more)
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
48 P62196 (/ISO) P62196 (/ISO) P62196 (/ISO) P62196 (/ISO) P62196 (/ISO) P62196 (/ISO) P62196 (/ISO) P62196 (/ISO) P62196 (/ISO) P62196 (/ISO)
(38 more)
Regulation of cellular amino acid metabolic process GO:0006521
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids.
48 P62195 (/TAS) P62195 (/TAS) P62195 (/TAS) P62195 (/TAS) P62195 (/TAS) P62195 (/TAS) P62195 (/TAS) P62195 (/TAS) P62195 (/TAS) P62195 (/TAS)
(38 more)
Negative regulation of G2/M transition of mitotic cell cycle GO:0010972
Any signalling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle.
48 P62195 (/TAS) P62195 (/TAS) P62195 (/TAS) P62195 (/TAS) P62195 (/TAS) P62195 (/TAS) P62195 (/TAS) P62195 (/TAS) P62195 (/TAS) P62195 (/TAS)
(38 more)
Protein deubiquitination GO:0016579
The removal of one or more ubiquitin groups from a protein.
48 P62195 (/TAS) P62195 (/TAS) P62195 (/TAS) P62195 (/TAS) P62195 (/TAS) P62195 (/TAS) P62195 (/TAS) P62195 (/TAS) P62195 (/TAS) P62195 (/TAS)
(38 more)
Showing 1 to 10 of 54 entries

There are 38 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Proteasome complex GO:0000502
A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core.
213 P62194 (/ISS) P62194 (/ISS) P62194 (/ISS) P62194 (/ISS) P62194 (/ISS) P62194 (/ISS) P62194 (/ISS) P62194 (/ISS) P62194 (/ISS) P62194 (/ISS)
(203 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
196 P62194 (/ISS) P62194 (/ISS) P62194 (/ISS) P62194 (/ISS) P62194 (/ISS) P62194 (/ISS) P62194 (/ISS) P62194 (/ISS) P62194 (/ISS) P62194 (/ISS)
(186 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
196 P62194 (/ISS) P62194 (/ISS) P62194 (/ISS) P62194 (/ISS) P62194 (/ISS) P62194 (/ISS) P62194 (/ISS) P62194 (/ISS) P62194 (/ISS) P62194 (/ISS)
(186 more)
Proteasome accessory complex GO:0022624
A protein complex, that caps one or both ends of the proteasome core complex and regulates entry into, or exit from, the proteasome core complex.
193 P46470 (/ISS) P62194 (/ISS) P62194 (/ISS) P62194 (/ISS) P62194 (/ISS) P62194 (/ISS) P62194 (/ISS) P62194 (/ISS) P62194 (/ISS) P62194 (/ISS)
(183 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
106 O18413 (/IDA) P62195 (/IDA) P62195 (/IDA) P62195 (/IDA) P62195 (/IDA) P62195 (/IDA) P62195 (/IDA) P62195 (/IDA) P62195 (/IDA) P62195 (/IDA)
(96 more)
Proteasome complex GO:0000502
A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core.
100 P62195 (/IDA) P62195 (/IDA) P62195 (/IDA) P62195 (/IDA) P62195 (/IDA) P62195 (/IDA) P62195 (/IDA) P62195 (/IDA) P62195 (/IDA) P62195 (/IDA)
(90 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
49 P41836 (/HDA) P62195 (/HDA) P62195 (/HDA) P62195 (/HDA) P62195 (/HDA) P62195 (/HDA) P62195 (/HDA) P62195 (/HDA) P62195 (/HDA) P62195 (/HDA)
(39 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
49 O18413 (/TAS) P62195 (/TAS) P62195 (/TAS) P62195 (/TAS) P62195 (/TAS) P62195 (/TAS) P62195 (/TAS) P62195 (/TAS) P62195 (/TAS) P62195 (/TAS)
(39 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
49 O18413 (/IDA) P62195 (/IDA) P62195 (/IDA) P62195 (/IDA) P62195 (/IDA) P62195 (/IDA) P62195 (/IDA) P62195 (/IDA) P62195 (/IDA) P62195 (/IDA)
(39 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
49 O18413 (/TAS) P62195 (/TAS) P62195 (/TAS) P62195 (/TAS) P62195 (/TAS) P62195 (/TAS) P62195 (/TAS) P62195 (/TAS) P62195 (/TAS) P62195 (/TAS)
(39 more)
Showing 1 to 10 of 38 entries
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