The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Nucleic acid-binding proteins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 113: polyribonucleotide nucleotidyltransferase 1, mitoc...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 17 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
3'-5'-exoribonuclease activity GO:0000175
Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule.
3 Q5RCW2 (/ISS) Q5RCW2 (/ISS) Q8K1R3 (/ISS)
Polyribonucleotide nucleotidyltransferase activity GO:0004654
Catalysis of the reaction: RNA(n+1) + phosphate <=> RNA(n) + a nucleoside diphosphate.
3 Q5RCW2 (/ISS) Q5RCW2 (/ISS) Q8K1R3 (/ISS)
Poly(U) RNA binding GO:0008266
Interacting selectively and non-covalently with a sequence of uracil residues in an RNA molecule.
3 Q5RCW2 (/ISS) Q5RCW2 (/ISS) Q8K1R3 (/ISS)
Poly(G) binding GO:0034046
Interacting selectively and non-covalently with a sequence of guanine residues in an RNA molecule.
3 Q5RCW2 (/ISS) Q5RCW2 (/ISS) Q8K1R3 (/ISS)
MiRNA binding GO:0035198
Interacting selectively and non-covalently with a microRNA, a 21-23 nucleotide RNA that is processed from a stem-loop RNA precursor (pre-miRNA) that is encoded within plant and animal genomes.
3 Q5RCW2 (/ISS) Q5RCW2 (/ISS) Q8K1R3 (/ISS)
Polyribonucleotide nucleotidyltransferase activity GO:0004654
Catalysis of the reaction: RNA(n+1) + phosphate <=> RNA(n) + a nucleoside diphosphate.
2 G3V6G7 (/IDA) Q8TCS8 (/IDA)
3'-5'-exoribonuclease activity GO:0000175
Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule.
1 Q8TCS8 (/IDA)
3'-5'-exoribonuclease activity GO:0000175
Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule.
1 Q8K1R3 (/ISO)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
1 Q8TCS8 (/HDA)
Polyribonucleotide nucleotidyltransferase activity GO:0004654
Catalysis of the reaction: RNA(n+1) + phosphate <=> RNA(n) + a nucleoside diphosphate.
1 Q8K1R3 (/ISO)
Showing 1 to 10 of 17 entries

There are 72 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Regulation of mitochondrial mRNA stability GO:0044528
Any process that modulates the propensity of mitochondrial mRNA molecules to degradation. Includes processes that both stabilize and destabilize mitochondrial mRNAs.
4 Q5U1D1 (/IMP) Q8IH29 (/IMP) Q95RX7 (/IMP) Q9V9X7 (/IMP)
Mitochondrial RNA catabolic process GO:0000957
The chemical reactions and pathways resulting in the breakdown of RNA transcribed from the mitochondrial genome and occurring in the mitochondrion.
3 Q5RCW2 (/ISS) Q5RCW2 (/ISS) Q8K1R3 (/ISS)
Positive regulation of mitochondrial RNA catabolic process GO:0000962
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving catabolism in the mitochondrion of RNA transcribed from the mitochondrial genome.
3 Q5RCW2 (/ISS) Q5RCW2 (/ISS) Q8K1R3 (/ISS)
Mitochondrial RNA 5'-end processing GO:0000964
Any process involved in forming the mature 5' end of an RNA molecule transcribed from a mitochondrial genome; occurs in the mitochondrion.
3 Q5RCW2 (/ISS) Q5RCW2 (/ISS) Q8K1R3 (/ISS)
Mitochondrial RNA 3'-end processing GO:0000965
Any process involved in forming the mature 3' end of an RNA molecule transcribed from a mitochondrial genome; occurs in the mitochondrion.
3 Q5RCW2 (/ISS) Q5RCW2 (/ISS) Q8K1R3 (/ISS)
RNA catabolic process GO:0006401
The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.
3 Q5RCW2 (/ISS) Q5RCW2 (/ISS) Q8K1R3 (/ISS)
MRNA catabolic process GO:0006402
The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes.
3 Q5RCW2 (/ISS) Q5RCW2 (/ISS) Q8K1R3 (/ISS)
Cellular response to oxidative stress GO:0034599
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
3 Q5RCW2 (/ISS) Q5RCW2 (/ISS) Q8K1R3 (/ISS)
RNA import into mitochondrion GO:0035927
The process in which a rRNA, ribosomal ribonucleic acid, is transported from the cytosol, into the mitochondrial matrix.
3 Q5RCW2 (/ISS) Q5RCW2 (/ISS) Q8K1R3 (/ISS)
RRNA import into mitochondrion GO:0035928
The process in which a rRNA, ribosomal ribonucleic acid, transported from the cytosol, into the mitochondrial matrix.
3 Q5RCW2 (/ISS) Q5RCW2 (/ISS) Q8K1R3 (/ISS)
Showing 1 to 10 of 72 entries

There are 19 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Mitochondrial degradosome GO:0045025
A mitochondrial protein complex with 3' to 5' exoribonuclease activity that participates in intron-independent turnover and processing of mitochondrial transcripts. In humans, the mitochondrial degradosome is a pentameric complex, and in yeast it exists as a heterodimer.
3 Q5RCW2 (/ISS) Q5RCW2 (/ISS) Q8K1R3 (/ISS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 Q8K1R3 (/IDA) Q8TCS8 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 Q5RCW2 (/ISS) Q5RCW2 (/ISS)
Mitochondrial intermembrane space GO:0005758
The region between the inner and outer lipid bilayers of the mitochondrial envelope.
2 Q8K1R3 (/IDA) Q8TCS8 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 G3V6G7 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q8K1R3 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q8TCS8 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q8K1R3 (/ISO)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q8K1R3 (/HDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q8K1R3 (/ISO)
Showing 1 to 10 of 19 entries
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