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CATH Superfamily 2.40.50.100

RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 30: Macrolide transporter subunit MacA

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Efflux transmembrane transporter activity GO:0015562
Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane.
 6 Q5DIV1 (/IDA) Q5DIV1 (/IDA) Q5DIV1 (/IDA) Q9I191 (/IDA) Q9I191 (/IDA) Q9I191 (/IDA)
Efflux transmembrane transporter activity GO:0015562
Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane.
 6 Q5DIV1 (/IMP) Q5DIV1 (/IMP) Q5DIV1 (/IMP) Q9I191 (/IMP) Q9I191 (/IMP) Q9I191 (/IMP)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
 4 P75830 (/IPI) P75830 (/IPI) Q2EHL9 (/IPI) Q2EHL9 (/IPI)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
 2 P75830 (/IPI) P75830 (/IPI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
 2 P75830 (/IDA) P75830 (/IDA)

There are 3 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Pyoverdine biosynthetic process GO:0002049
The chemical reactions and pathways resulting in the formation of the siderochrome pyoverdine.
 6 Q5DIV1 (/IMP) Q5DIV1 (/IMP) Q5DIV1 (/IMP) Q9I191 (/IMP) Q9I191 (/IMP) Q9I191 (/IMP)
Drug export GO:0046618
The directed movement of a drug, a substance used in the diagnosis, treatment or prevention of a disease, out of a cell or organelle.
 2 P75830 (/IDA) P75830 (/IDA)
Drug export GO:0046618
The directed movement of a drug, a substance used in the diagnosis, treatment or prevention of a disease, out of a cell or organelle.
 2 P75830 (/IMP) P75830 (/IMP)

There are 5 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Efflux pump complex GO:1990281
A protein complex that is capable of efflux transmembrane transporter activity.
 6 Q5DIV1 (/IDA) Q5DIV1 (/IDA) Q5DIV1 (/IDA) Q9I191 (/IDA) Q9I191 (/IDA) Q9I191 (/IDA)
Efflux pump complex GO:1990281
A protein complex that is capable of efflux transmembrane transporter activity.
 6 Q5DIV1 (/IMP) Q5DIV1 (/IMP) Q5DIV1 (/IMP) Q9I191 (/IMP) Q9I191 (/IMP) Q9I191 (/IMP)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
 2 P75830 (/IDA) P75830 (/IDA)
Extrinsic component of membrane GO:0019898
The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
 2 P75830 (/IDA) P75830 (/IDA)
MacAB-TolC complex GO:1990196
The MacAB-TolC complex is a macrolide transporter complex found in E.coli and related gram-negative bacteria. Its transport activity is specific to macrolide compounds containing 14- and 15-membered lactones. It consists of the dimeric inner membrane ATPase MacB, the hexameric, periplasmic membrane fusion protein MacA and the trimeric outer membrane factor TolC.
 2 P75830 (/IDA) P75830 (/IDA)