The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 3: ATPase H+ transporting accessory protein 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 3 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Rab GTPase binding GO:0017137
Interacting selectively and non-covalently with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases.
13 A0A2J8RLX8 (/ISS) A9CB63 (/ISS) A9CB63 (/ISS) A9CB63 (/ISS) G1RVI5 (/ISS) G2HGS7 (/ISS) I2CYP6 (/ISS) I2CYP6 (/ISS) I2CYP6 (/ISS) K9IWA3 (/ISS)
(3 more)
Transporter activity GO:0005215
Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells.
2 Q15904 (/TAS) Q15904 (/TAS)
Rab GTPase binding GO:0017137
Interacting selectively and non-covalently with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases.
2 Q9R1Q9 (/IPI) Q9R1Q9 (/IPI)

There are 40 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of osteoblast differentiation GO:0045669
Any process that activates or increases the frequency, rate or extent of osteoblast differentiation.
13 A0A2J8RLX8 (/ISS) A9CB63 (/ISS) A9CB63 (/ISS) A9CB63 (/ISS) G1RVI5 (/ISS) G2HGS7 (/ISS) I2CYP6 (/ISS) I2CYP6 (/ISS) I2CYP6 (/ISS) K9IWA3 (/ISS)
(3 more)
Positive regulation of bone resorption GO:0045780
Any process that activates or increases the frequency, rate or extent of bone resorption.
13 A0A2J8RLX8 (/ISS) A9CB63 (/ISS) A9CB63 (/ISS) A9CB63 (/ISS) G1RVI5 (/ISS) G2HGS7 (/ISS) I2CYP6 (/ISS) I2CYP6 (/ISS) I2CYP6 (/ISS) K9IWA3 (/ISS)
(3 more)
PH reduction GO:0045851
Any process that reduces the internal pH of an organism, part of an organism or a cell, measured by the concentration of the hydrogen ion.
13 A0A2J8RLX8 (/ISS) A9CB63 (/ISS) A9CB63 (/ISS) A9CB63 (/ISS) G1RVI5 (/ISS) G2HGS7 (/ISS) I2CYP6 (/ISS) I2CYP6 (/ISS) I2CYP6 (/ISS) K9IWA3 (/ISS)
(3 more)
Positive regulation of exocytosis GO:0045921
Any process that activates or increases the frequency, rate or extent of exocytosis.
13 A0A2J8RLX8 (/ISS) A9CB63 (/ISS) A9CB63 (/ISS) A9CB63 (/ISS) G1RVI5 (/ISS) G2HGS7 (/ISS) I2CYP6 (/ISS) I2CYP6 (/ISS) I2CYP6 (/ISS) K9IWA3 (/ISS)
(3 more)
Establishment of organelle localization GO:0051656
The directed movement of an organelle to a specific location.
13 A0A2J8RLX8 (/ISS) A9CB63 (/ISS) A9CB63 (/ISS) A9CB63 (/ISS) G1RVI5 (/ISS) G2HGS7 (/ISS) I2CYP6 (/ISS) I2CYP6 (/ISS) I2CYP6 (/ISS) K9IWA3 (/ISS)
(3 more)
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
13 A0A2J8RLX8 (/ISS) A9CB63 (/ISS) A9CB63 (/ISS) A9CB63 (/ISS) G1RVI5 (/ISS) G2HGS7 (/ISS) I2CYP6 (/ISS) I2CYP6 (/ISS) I2CYP6 (/ISS) K9IWA3 (/ISS)
(3 more)
Positive regulation of osteoclast development GO:2001206
Any process that activates or increases the frequency, rate or extent of osteoclast development.
13 A0A2J8RLX8 (/ISS) A9CB63 (/ISS) A9CB63 (/ISS) A9CB63 (/ISS) G1RVI5 (/ISS) G2HGS7 (/ISS) I2CYP6 (/ISS) I2CYP6 (/ISS) I2CYP6 (/ISS) K9IWA3 (/ISS)
(3 more)
Cellular iron ion homeostasis GO:0006879
Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell.
4 O54715 (/ISS) P40682 (/ISS) Q9R1Q9 (/ISS) Q9R1Q9 (/ISS)
Cellular response to increased oxygen levels GO:0036295
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting an increase in the level of oxygen.
4 O54715 (/ISS) P40682 (/ISS) Q9R1Q9 (/ISS) Q9R1Q9 (/ISS)
Determination of left/right asymmetry in lateral mesoderm GO:0003140
The establishment of the lateral mesoderm with respect to the left and right halves.
3 A2AR67 (/IMP) Q5U3H5 (/IMP) Q8JIU5 (/IMP)
Retinal pigment epithelium development GO:0003406
The progression of the retinal pigment epithelium over time, from its initial formation to the mature structure. The retinal pigment epithelium is the melanin-containing layer of cells between the retina and the choroid that absorbs scattered and reflected light and removes waste products produced by the photoreceptor cells.
3 A2AR67 (/IMP) Q5U3H5 (/IMP) Q8JIU5 (/IMP)
Eye pigment granule organization GO:0008057
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of intracellular pigment storage granules in the eye.
3 A2AR67 (/IMP) Q5U3H5 (/IMP) Q8JIU5 (/IMP)
Regulation of cellular pH GO:0030641
Any process involved in the maintenance of an internal equilibrium of hydrogen ions (protons) within a cell or between a cell and its external environment.
3 A2AR67 (/IMP) Q5U3H5 (/IMP) Q8JIU5 (/IMP)
Melanosome organization GO:0032438
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a melanosome. A melanosome is a tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored.
3 A2AR67 (/IMP) Q5U3H5 (/IMP) Q8JIU5 (/IMP)
Cellular protein localization GO:0034613
Any process in which a protein is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell.
3 A2AR67 (/IMP) Q5U3H5 (/IMP) Q8JIU5 (/IMP)
Regulation of cell population proliferation GO:0042127
Any process that modulates the frequency, rate or extent of cell proliferation.
3 A2AR67 (/IMP) Q5U3H5 (/IMP) Q8JIU5 (/IMP)
Retina development in camera-type eye GO:0060041
The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates.
3 A2AR67 (/IMP) Q5U3H5 (/IMP) Q8JIU5 (/IMP)
Kupffer's vesicle development GO:0070121
The progression of the Kupffer's vesicle over time from its initial formation until its mature state. The Kupffer's vesicle is a small but distinctive epithelial sac containing fluid, located midventrally posterior to the yolk cell or its extension, and transiently present during most of the segmentation period.
3 A2AR67 (/IMP) Q5U3H5 (/IMP) Q8JIU5 (/IMP)
Protein localization to plasma membrane GO:0072659
A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.
3 A2AR67 (/IMP) Q5U3H5 (/IMP) Q8JIU5 (/IMP)
Regulation of heart looping GO:1901207
Any process that modulates the frequency, rate or extent of heart looping.
3 A2AR67 (/IGI) Q5U3H5 (/IGI) Q8JIU5 (/IGI)
Regulation of heart looping GO:1901207
Any process that modulates the frequency, rate or extent of heart looping.
3 A2AR67 (/IMP) Q5U3H5 (/IMP) Q8JIU5 (/IMP)
Regulation of cilium assembly GO:1902017
Any process that modulates the frequency, rate or extent of cilium assembly.
3 A2AR67 (/IMP) Q5U3H5 (/IMP) Q8JIU5 (/IMP)
Cellular iron ion homeostasis GO:0006879
Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell.
2 Q15904 (/IMP) Q15904 (/IMP)
Cellular iron ion homeostasis GO:0006879
Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell.
2 Q9R1Q9 (/ISO) Q9R1Q9 (/ISO)
Cell death GO:0008219
Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538).
2 Q9R1Q9 (/ISO) Q9R1Q9 (/ISO)
Insulin receptor signaling pathway GO:0008286
The series of molecular signals generated as a consequence of the insulin receptor binding to insulin.
2 Q15904 (/TAS) Q15904 (/TAS)
Transferrin transport GO:0033572
The directed movement of transferrin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 Q15904 (/TAS) Q15904 (/TAS)
Ion transmembrane transport GO:0034220
A process in which an ion is transported across a membrane.
2 Q15904 (/TAS) Q15904 (/TAS)
Cellular response to increased oxygen levels GO:0036295
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting an increase in the level of oxygen.
2 Q15904 (/IMP) Q15904 (/IMP)
Cellular response to increased oxygen levels GO:0036295
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting an increase in the level of oxygen.
2 Q9R1Q9 (/ISO) Q9R1Q9 (/ISO)
Positive regulation of osteoblast differentiation GO:0045669
Any process that activates or increases the frequency, rate or extent of osteoblast differentiation.
2 Q9R1Q9 (/IMP) Q9R1Q9 (/IMP)
Positive regulation of bone resorption GO:0045780
Any process that activates or increases the frequency, rate or extent of bone resorption.
2 Q9R1Q9 (/IMP) Q9R1Q9 (/IMP)
PH reduction GO:0045851
Any process that reduces the internal pH of an organism, part of an organism or a cell, measured by the concentration of the hydrogen ion.
2 Q9R1Q9 (/IMP) Q9R1Q9 (/IMP)
Positive regulation of exocytosis GO:0045921
Any process that activates or increases the frequency, rate or extent of exocytosis.
2 Q9R1Q9 (/IMP) Q9R1Q9 (/IMP)
Establishment of organelle localization GO:0051656
The directed movement of an organelle to a specific location.
2 Q9R1Q9 (/IMP) Q9R1Q9 (/IMP)
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
2 Q9R1Q9 (/IMP) Q9R1Q9 (/IMP)
Proton transmembrane transport GO:1902600
The directed movement of a proton across a membrane.
2 Q15904 (/TAS) Q15904 (/TAS)
Positive regulation of osteoclast development GO:2001206
Any process that activates or increases the frequency, rate or extent of osteoclast development.
2 Q9R1Q9 (/IMP) Q9R1Q9 (/IMP)
Aging GO:0007568
A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700).
1 O54715 (/IEP)
Cell death GO:0008219
Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538).
1 O54715 (/IMP)

There are 4 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 A2AR67 (/IDA) Q5U3H5 (/IDA) Q8JIU5 (/IDA)
Endosome membrane GO:0010008
The lipid bilayer surrounding an endosome.
2 Q15904 (/TAS) Q15904 (/TAS)
Proton-transporting two-sector ATPase complex GO:0016469
A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible.
2 Q15904 (/TAS) Q15904 (/TAS)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
2 Q15904 (/HDA) Q15904 (/HDA)