The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Trypsin-like serine proteases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 86: serine protease hepsin

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Serine-type peptidase activity GO:0008236
Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
10 A1L5C6 (/ISS) E2RKP5 (/ISS) E2RKP5 (/ISS) F7B8K3 (/ISS) G1L013 (/ISS) G1NYX6 (/ISS) G1RJH3 (/ISS) G1U4B0 (/ISS) O35453 (/ISS) Q05511 (/ISS)
Calcium-activated potassium channel activity GO:0015269
Enables the calcium concentration-regulatable energy-independent passage of potassium ions across a lipid bilayer down a concentration gradient.
9 A1L5C6 (/ISS) E2RKP5 (/ISS) E2RKP5 (/ISS) F7B8K3 (/ISS) G1L013 (/ISS) G1NYX6 (/ISS) G1RJH3 (/ISS) G1U4B0 (/ISS) Q05511 (/ISS)
Serine-type endopeptidase activity GO:0004252
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
1 O35453 (/ISO)
Peptidase activity GO:0008233
Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
1 O35453 (/ISO)
Serine-type peptidase activity GO:0008236
Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
1 O35453 (/ISO)
Calcium-activated potassium channel activity GO:0015269
Enables the calcium concentration-regulatable energy-independent passage of potassium ions across a lipid bilayer down a concentration gradient.
1 O35453 (/IMP)

There are 38 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
10 A1L5C6 (/ISS) E2RKP5 (/ISS) E2RKP5 (/ISS) F7B8K3 (/ISS) G1L013 (/ISS) G1NYX6 (/ISS) G1RJH3 (/ISS) G1U4B0 (/ISS) O35453 (/ISS) Q05511 (/ISS)
Regulation of cell shape GO:0008360
Any process that modulates the surface configuration of a cell.
10 A1L5C6 (/ISS) E2RKP5 (/ISS) E2RKP5 (/ISS) F7B8K3 (/ISS) G1L013 (/ISS) G1NYX6 (/ISS) G1RJH3 (/ISS) G1U4B0 (/ISS) O35453 (/ISS) Q05511 (/ISS)
Negative regulation of epithelial to mesenchymal transition GO:0010719
Any process that decreases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
10 A1L5C6 (/ISS) E2RKP5 (/ISS) E2RKP5 (/ISS) F7B8K3 (/ISS) G1L013 (/ISS) G1NYX6 (/ISS) G1RJH3 (/ISS) G1U4B0 (/ISS) O35453 (/ISS) Q05511 (/ISS)
Positive regulation of plasminogen activation GO:0010756
Any process that increases the rate, frequency or extent of plasminogen activation. Plasminogen activation is the process in which plasminogen is processed to plasmin.
10 A1L5C6 (/ISS) E2RKP5 (/ISS) E2RKP5 (/ISS) F7B8K3 (/ISS) G1L013 (/ISS) G1NYX6 (/ISS) G1RJH3 (/ISS) G1U4B0 (/ISS) O35453 (/ISS) Q05511 (/ISS)
Positive regulation of cell growth GO:0030307
Any process that activates or increases the frequency, rate, extent or direction of cell growth.
10 A1L5C6 (/ISS) E2RKP5 (/ISS) E2RKP5 (/ISS) F7B8K3 (/ISS) G1L013 (/ISS) G1NYX6 (/ISS) G1RJH3 (/ISS) G1U4B0 (/ISS) O35453 (/ISS) Q05511 (/ISS)
Basement membrane disassembly GO:0034769
The controlled breakdown of the basement membrane in the context of a normal process such as imaginal disc eversion.
10 A1L5C6 (/ISS) E2RKP5 (/ISS) E2RKP5 (/ISS) F7B8K3 (/ISS) G1L013 (/ISS) G1NYX6 (/ISS) G1RJH3 (/ISS) G1U4B0 (/ISS) O35453 (/ISS) Q05511 (/ISS)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
10 A1L5C6 (/ISS) E2RKP5 (/ISS) E2RKP5 (/ISS) F7B8K3 (/ISS) G1L013 (/ISS) G1NYX6 (/ISS) G1RJH3 (/ISS) G1U4B0 (/ISS) O35453 (/ISS) Q05511 (/ISS)
Positive regulation by host of viral transcription GO:0043923
Any process in which a host organism activates or increases the frequency, rate or extent of viral transcription, the synthesis of either RNA on a template of DNA or DNA on a template of RNA.
10 A1L5C6 (/ISS) E2RKP5 (/ISS) E2RKP5 (/ISS) F7B8K3 (/ISS) G1L013 (/ISS) G1NYX6 (/ISS) G1RJH3 (/ISS) G1U4B0 (/ISS) O35453 (/ISS) Q05511 (/ISS)
Negative regulation of epithelial cell proliferation GO:0050680
Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation.
10 A1L5C6 (/ISS) E2RKP5 (/ISS) E2RKP5 (/ISS) F7B8K3 (/ISS) G1L013 (/ISS) G1NYX6 (/ISS) G1RJH3 (/ISS) G1U4B0 (/ISS) O35453 (/ISS) Q05511 (/ISS)
Positive regulation of hepatocyte proliferation GO:2000347
Any process that activates or increases the frequency, rate or extent of hepatocyte proliferation.
10 A1L5C6 (/ISS) E2RKP5 (/ISS) E2RKP5 (/ISS) F7B8K3 (/ISS) G1L013 (/ISS) G1NYX6 (/ISS) G1RJH3 (/ISS) G1U4B0 (/ISS) O35453 (/ISS) Q05511 (/ISS)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
9 A1L5C6 (/ISS) E2RKP5 (/ISS) E2RKP5 (/ISS) F7B8K3 (/ISS) G1L013 (/ISS) G1NYX6 (/ISS) G1RJH3 (/ISS) G1U4B0 (/ISS) Q05511 (/ISS)
Detection of mechanical stimulus involved in sensory perception of sound GO:0050910
The series of events involved in the perception of sound vibration in which the vibration is received and converted into a molecular signal.
9 A1L5C6 (/ISS) E2RKP5 (/ISS) E2RKP5 (/ISS) F7B8K3 (/ISS) G1L013 (/ISS) G1NYX6 (/ISS) G1RJH3 (/ISS) G1U4B0 (/ISS) Q05511 (/ISS)
Potassium ion transmembrane transport GO:0071805
A process in which a potassium ion is transported from one side of a membrane to the other.
9 A1L5C6 (/ISS) E2RKP5 (/ISS) E2RKP5 (/ISS) F7B8K3 (/ISS) G1L013 (/ISS) G1NYX6 (/ISS) G1RJH3 (/ISS) G1U4B0 (/ISS) Q05511 (/ISS)
Cochlea morphogenesis GO:0090103
The process in which the cochlea is generated and organized.
9 A1L5C6 (/ISS) E2RKP5 (/ISS) E2RKP5 (/ISS) F7B8K3 (/ISS) G1L013 (/ISS) G1NYX6 (/ISS) G1RJH3 (/ISS) G1U4B0 (/ISS) Q05511 (/ISS)
Response to thyroid hormone GO:0097066
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroid hormone stimulus.
9 A1L5C6 (/ISS) E2RKP5 (/ISS) E2RKP5 (/ISS) F7B8K3 (/ISS) G1L013 (/ISS) G1NYX6 (/ISS) G1RJH3 (/ISS) G1U4B0 (/ISS) Q05511 (/ISS)
Pilomotor reflex GO:0097195
The reflex process in which the arrectores pilorum (hair follicle) muscles contract and cause the hair to stand erect.
9 A1L5C6 (/ISS) E2RKP5 (/ISS) E2RKP5 (/ISS) F7B8K3 (/ISS) G1L013 (/ISS) G1NYX6 (/ISS) G1RJH3 (/ISS) G1U4B0 (/ISS) Q05511 (/ISS)
Positive regulation of thyroid hormone generation GO:2000611
Any process that activates or increases the frequency, rate or extent of thyroid hormone generation.
9 A1L5C6 (/ISS) E2RKP5 (/ISS) E2RKP5 (/ISS) F7B8K3 (/ISS) G1L013 (/ISS) G1NYX6 (/ISS) G1RJH3 (/ISS) G1U4B0 (/ISS) Q05511 (/ISS)
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
1 O35453 (/ISO)
Sensory perception of sound GO:0007605
The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound.
1 O35453 (/IMP)
Regulation of cell shape GO:0008360
Any process that modulates the surface configuration of a cell.
1 O35453 (/ISO)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 O35453 (/IMP)
Negative regulation of alkaline phosphatase activity GO:0010693
Any process that decreases the frequency, rate or extent of alkaline phosphatase activity, the catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum.
1 O35453 (/IMP)
Negative regulation of epithelial to mesenchymal transition GO:0010719
Any process that decreases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
1 O35453 (/ISO)
Positive regulation of plasminogen activation GO:0010756
Any process that increases the rate, frequency or extent of plasminogen activation. Plasminogen activation is the process in which plasminogen is processed to plasmin.
1 O35453 (/ISO)
Positive regulation of cell growth GO:0030307
Any process that activates or increases the frequency, rate, extent or direction of cell growth.
1 O35453 (/ISO)
Basement membrane disassembly GO:0034769
The controlled breakdown of the basement membrane in the context of a normal process such as imaginal disc eversion.
1 O35453 (/ISO)
Cholesterol homeostasis GO:0042632
Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell.
1 O35453 (/IMP)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
1 O35453 (/ISO)
Positive regulation by host of viral transcription GO:0043923
Any process in which a host organism activates or increases the frequency, rate or extent of viral transcription, the synthesis of either RNA on a template of DNA or DNA on a template of RNA.
1 O35453 (/ISO)
Negative regulation of epithelial cell proliferation GO:0050680
Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation.
1 O35453 (/ISO)
Detection of mechanical stimulus involved in sensory perception of sound GO:0050910
The series of events involved in the perception of sound vibration in which the vibration is received and converted into a molecular signal.
1 O35453 (/IMP)
Epithelium development GO:0060429
The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure.
1 O35453 (/IEP)
Potassium ion transmembrane transport GO:0071805
A process in which a potassium ion is transported from one side of a membrane to the other.
1 O35453 (/IMP)
Cochlea morphogenesis GO:0090103
The process in which the cochlea is generated and organized.
1 O35453 (/IMP)
Response to thyroid hormone GO:0097066
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroid hormone stimulus.
1 O35453 (/IMP)
Pilomotor reflex GO:0097195
The reflex process in which the arrectores pilorum (hair follicle) muscles contract and cause the hair to stand erect.
1 O35453 (/IMP)
Positive regulation of hepatocyte proliferation GO:2000347
Any process that activates or increases the frequency, rate or extent of hepatocyte proliferation.
1 O35453 (/ISO)
Positive regulation of thyroid hormone generation GO:2000611
Any process that activates or increases the frequency, rate or extent of thyroid hormone generation.
1 O35453 (/IMP)

There are 15 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
10 A1L5C6 (/ISS) E2RKP5 (/ISS) E2RKP5 (/ISS) F7B8K3 (/ISS) G1L013 (/ISS) G1NYX6 (/ISS) G1RJH3 (/ISS) G1U4B0 (/ISS) O35453 (/ISS) Q05511 (/ISS)
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
10 A1L5C6 (/ISS) E2RKP5 (/ISS) E2RKP5 (/ISS) F7B8K3 (/ISS) G1L013 (/ISS) G1NYX6 (/ISS) G1RJH3 (/ISS) G1U4B0 (/ISS) O35453 (/ISS) Q05511 (/ISS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
10 A1L5C6 (/ISS) E2RKP5 (/ISS) E2RKP5 (/ISS) F7B8K3 (/ISS) G1L013 (/ISS) G1NYX6 (/ISS) G1RJH3 (/ISS) G1U4B0 (/ISS) O35453 (/ISS) Q05511 (/ISS)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
10 A1L5C6 (/ISS) E2RKP5 (/ISS) E2RKP5 (/ISS) F7B8K3 (/ISS) G1L013 (/ISS) G1NYX6 (/ISS) G1RJH3 (/ISS) G1U4B0 (/ISS) O35453 (/ISS) Q05511 (/ISS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
9 A1L5C6 (/ISS) E2RKP5 (/ISS) E2RKP5 (/ISS) F7B8K3 (/ISS) G1L013 (/ISS) G1NYX6 (/ISS) G1RJH3 (/ISS) G1U4B0 (/ISS) Q05511 (/ISS)
Cell-cell junction GO:0005911
A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals.
9 A1L5C6 (/ISS) E2RKP5 (/ISS) E2RKP5 (/ISS) F7B8K3 (/ISS) G1L013 (/ISS) G1NYX6 (/ISS) G1RJH3 (/ISS) G1U4B0 (/ISS) Q05511 (/ISS)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
9 A1L5C6 (/ISS) E2RKP5 (/ISS) E2RKP5 (/ISS) F7B8K3 (/ISS) G1L013 (/ISS) G1NYX6 (/ISS) G1RJH3 (/ISS) G1U4B0 (/ISS) Q05511 (/ISS)
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
1 O35453 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 O35453 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 O35453 (/ISO)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 O35453 (/ISO)
Cell-cell junction GO:0005911
A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals.
1 O35453 (/IMP)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
1 O35453 (/ISO)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 O35453 (/ISO)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
1 O35453 (/IDA)