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CATH Superfamily 2.40.10.10

Trypsin-like serine proteases

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Trypsin-like serine proteases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 52: Neutrophil elastase

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Leukocyte elastase. [EC: 3.4.21.37]
Hydrolysis of proteins, including elastin. Preferential cleavage: Val-|-Xaa > Ala-|-Xaa.
  • Differs from pancreatic elastase in specificity on synthetic substrates and in inhibitor sensitivity.
  • Belongs to peptidase family S1.
  • Formerly EC 3.4.4.7 and EC 3.4.21.11.
 2 P08246 Q3UP87
Myeloblastin. [EC: 3.4.21.76]
Hydrolysis of proteins, including elastin, by preferential cleavage: -Ala-|-Xaa- > -Val-|-Xaa-.
  • Not inhibited by secretory leukocyte proteinase inhibitor.
  • Belongs to peptidase family S1.
 2 P24158 Q61096
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