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CATH Superfamily 2.40.10.10

Trypsin-like serine proteases

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Trypsin-like serine proteases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
SC:1Tryptase gamma 1Transmembrane serine protease 7Serine endoprotease DegS, periplasmicCoagulation factor XHepatocyte growth factorSerine protease easterComplement C1r subcomponentmannan-binding lectin serine protease 1 isoform X1Complement C1s subcomponentAcrosinHepatocyte growth factor-like proteinProthrombinTrypsin alphaKallikrein 8 (Neuropsin/ovasin)kallikrein-6 isoform X1Mannan-binding lectin serine protease 2Coagulation factor XIISerine protease HtrAGenome polyproteinChymotrypsin-like elastase family member 1Cationic trypsinProstasinGlandular kallikrein-10Granzyme HProbable serine protease PepD (Serine proteinase) (MTB32B)Vitamin K-dependent protein CAnionic trypsin isoform 1Coagulation factor XIProtease Do-like 5, chloroplasticMyeloblastinSC:3Kallikrein related peptidase 11Tryptase beta-2Hepatocyte growth factorserine proteases 1/2HaptoglobinComplement C1r subcomponentTrypsin betaNeutrophil elastaseHepatocyte growth factor-like 1mannan-binding lectin serine protease 1 isoform X1Urokinase-type plasminogen activatorComplement C1s subcomponentSerine protease easterProthrombinserine protease hepsinMannan-binding lectin serine protease 2Coagulation factor XIIKallikrein related-peptidase 10Protein Z, vitamin K-dependent plasma glycoproteinGenome polyproteinProstate-specific antigenSerine protease grassSerine protease Rv3671cAnionic trypsin-2AzurocidinSC:4Complement C1r subcomponentSC:5Genome polyproteinGenome polyproteinSC:6HaptoglobinProtein Z, vitamin K-dependent plasma glycoproteinSC:7Complement factor ITrypsinGlandular kallikreinSC:8Phage baseplate hub subunitPeriplasmic serine protease DegSTransmembrane protease serineTransmembrane serine protease 3Serine protease 37Serine proteinase stubbleCationic trypsinCoagulation factor Xprotease Do-like 9Complement factor DAtrial natriuretic peptide-converting enzymeChymotrypsin-like elastase family member 1Anionic trypsinGenome polyproteinKallikrein 1Genome polyproteinSerine protease 53Genome polyproteinGenome polyproteinKallikrein 1-related peptidase C9Replicase polyprotein 1aEupolytinSerine proteaseBrain-specific serine protease 4Serine protease 23kallikrein-6 isoform X2Kallikrein 1-related peptidase C9serine proteases 1/2polyserase-2 isoform X1Replicase polyprotein 1aComplement factor b,-likeTrypsin etaserine protease 23probable inactive serine protease 37complement C2 isoform X1NeurotrypsinKallikrein related peptidase 11Zgc:100868Tissue-type plasminogen activatorHepatocyte growth factor activatorHepatocyte growth factortransmembrane protease serine 2Hyaluronan-binding protein 2Urokinase-type plasminogen activatorCLIP-domain serine proteaseglyoxysomal processing protease, glyoxysomal-likeStructural polyproteinStructural polyproteinPredicted proteinSerine protease H137Serine protease 53peroxisomal leader peptide-processing proteaseSerine protease 56Plasma kallikreinserine protease hepsinKallikrein-4Transmembrane protease serine 5Kallikrein related-peptidase 12Glyoxysomal processing protease glyoxysomalKallikrein-4Genome polyproteinDipeptidyl-peptidase 7Protease Do-like 1, chloroplasticInactive serine protease 45Probable threonine protease PRSS50TISP43 isoform 6HepsinHepsinBlast:Serine protease nudelMannan-binding lectin serine protease 1Zgc:112285ORF1a polyproteinSerine protease P16Chymotrypsinogen AORF1a polyproteinPutative serine proteasePeptidase S46 family proteinGenome polyproteininactive serine protease 54TISP43 isoform 4Probable threonine protease PRSS50S46 family peptidaseTequila, isoform DChymotrypsinogen AProtease Do-like 9Inactive serine protease 54Glyoxysomal processing protease glyoxysomalUncharacterized protein, isoform BCoagulation factor II (thrombin)Kallikrein related-peptidase 12GD22965Kallikrein related peptidase 11AcrosinCLIP-domain serine proteaseEnterokinase light chainClip-domain serine proteaseSerine protease PepAAGAP011783-PAGenome polyproteinSerine protease 53Kallikrein related peptidase 12CLIP-domain serine proteaseInactive serine protease 35Chymotrypsin-like protease CTRL-1Corin, isoform BPlasminogen activatorVenom plasminogen activator TSV-PAFamily with sequence similarity 111 member AFlocculation FLO11-like proteinMIP06385pGH18608pThrombin-like enzyme saxthrombinComplement C1r subcomponent likeProtease Do-like 7Serine protease DegPProtease Do-like 7AGAP001251-PAJonah 66CiiTrypsin-like serine proteaseCoagulation factor II (thrombin)Genome polyproteinSerine protease 3trypsin-1GG16564Possible proteaseChymotrypsinogen ASerine proteaseTrypsin-like serine proteaseGenome polyproteinIP09419pChymotrypsinogen AZgc:163079Complement component 1, s subcomponentProtease Do-like 5, chloroplasticSerine protease PepAUncharacterized protein, isoform ASi:dkeyp-93a5.2Ovochymase, putativeCoagulation factor II (Thrombin)GM21018CLIP-domain serine proteaseSecreted trypsin-like serine proteaseUncharacterized proteinUncharacterized protein, isoform BPutative low-density lipoprotein receptorchymotrypsin-1Trypsin, putativeSerine protease nudelRT07795pGD11897Membrane-associated serine proteaseLysyl endopeptidaseLysyl endopeptidaseSerine-peptidase 212Serine proteasetrypsin alpha-3serine proteinase stubble isoform X2Serine protease P53Si:dkey-33m11.7Protein Z, vitamin K-dependent plasma glycoprotein aTrypsin domain-containing 1Chymase 1HGF/MSP/plasminogen-like proteinSerine protease nudelUncharacterized proteinSerine protease 1Si:dkey-33m11.8GH15905pGM13756Protease, serine 51GD19101GD10792CG9649 proteinSi:dkey-33m11.7Serine protease 53Trypsin domain-containing 1Serine proteaseBlast:Transmembrane protease serine 6Coagulation factor VIIiAtrial natriuretic peptide-converting enzymePutative trypsinTrypsin, putativeKallikrein related peptidase 13Uncharacterized proteinSerine protease H29Haptoglobinchymotrypsinogen A-likeKLK4 isoform 6GM24079Elastase, neutrophil expressedinactive serine protease 35GG11533Zgc:100868AGAP009216-PAZgc:92511Serine protease H158Trypsin precursorUncharacterized proteinGM14069Transmembrane serine protease 5Transmembrane serine protease 5Uncharacterized proteinTrypsin precursorGM13457MIP04821pUncharacterized proteinUncharacterized proteinIP10114pGM15595AT07689pGG11998Serine proteaseTrypsin domain containing 1Uncharacterized protein, isoform CUncharacterized proteinSerine-type enodpeptidase, putativeCortical granule serine protease 1; Uncharacterized proteinSerine proteaseGranzyme-like ISi:ch211-212d10.1 proteinuncharacterized protein LOC100179458 isoform X1Modular serine proteaseInactive serine protease PAMR1GM18242IP19845pZgc:165423 proteinCoagulation factor precursor, putativeSerine protease easter-like Proteinelastase-1 isoform X1AGAP013254-PAGM13872serine protease gd isoform X1IP20273pAGAP011918-PAKLKBL4 proteinGM13374Putative peptidase Cgl1093Serine protease H65Uncharacterized protein, isoform DComplement component 1, r subcomponentPlasminogen activator, urokinaseUncharacterized proteinComplement component 1, r subcomponentMannose-binding lectin associated serine proteaseUncharacterized proteinCoagulation factor VIILP05421pSerine protease H164GH24985pprostasin-likeUncharacterized proteinGD15727Female reproductive tract proteaseAGAP001252-PAAGAP012315-PAIP19441pAGAP005310-PAMale accessory gland proteinAquariusGM19097Uncharacterized proteinProbable trypsin-like serine proteaseAGAP005196-PATransmembrane protease serine 9-like Protein
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FunFam 349:

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 1 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Peptidase activity GO:0008233
Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
 1 P29598 (/IDA)
Showing 1 to 1 of 1 entries

There are 22 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Angiogenesis GO:0001525
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
 1 P29598 (/IMP)
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
 1 P29598 (/IEP)
Embryo implantation GO:0007566
Attachment of the blastocyst to the uterine lining.
 1 P29598 (/IEP)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
 1 P29598 (/IMP)
Response to activity GO:0014823
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an activity stimulus.
 1 P29598 (/IEP)
Positive regulation of smooth muscle cell migration GO:0014911
Any process that activates, maintains or increases the frequency, rate or extent of smooth muscle cell migration.
 1 P29598 (/IMP)
Response to hepatocyte growth factor GO:0035728
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hepatocyte growth factor stimulus.
 1 P29598 (/IEP)
Cellular response to hepatocyte growth factor stimulus GO:0035729
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hepatocyte growth factor stimulus.
 1 P29598 (/IEP)
Wound healing GO:0042060
The series of events that restore integrity to a damaged tissue, following an injury.
 1 P29598 (/IEP)
Wound healing GO:0042060
The series of events that restore integrity to a damaged tissue, following an injury.
 1 P29598 (/IMP)
Showing 1 to 10 of 22 entries

There are 2 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
 1 P29598 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
 1 P29598 (/IDA)
Showing 1 to 2 of 2 entries
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