The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
SC:1Membrane associated guanylate kinase, WW and PDZ domain containing 1microtubule-associated serine/threonine-protein kinase 4 isoform X2Membrane associated guanylate kinase, WW and PDZ domain containing 1Glutamate receptor interacting protein 1PDZ domain containing ring finger 4Rho guanine nucleotide exchange factor (GEF) 11Glutamate receptor interacting protein 1Glutamate receptor interacting protein 1protein scribble homolog isoform X1Tyrosine-protein phosphatase non-receptor typeMAGUK p55 subfamily member 7disks large homolog 1 isoform X1PDZ and LIM domain protein 3multiple PDZ domain protein isoform X1Multiple PDZ domain proteinprotein scribble homolog isoform X2Tight junction protein ZO-2 isoform 2LIM domain kinase 2 isoform X2disks large homolog 1 isoform X8PDZ domain-containing protein GIPC1 isoform 1regulator of G-protein signaling 3 isoform X1Shroom family member 2inaD-like protein isoform X3Membrane associated guanylate kinase, WW and PDZ domain containing 2protein scribble homolog isoform X1Regulator of G-protein signaling 12Tax1-binding protein 3PDZ domain containing ring finger 4LIM domain only 7Membrane associated guanylate kinase, WW and PDZ domain containing 2T cell lymphoma invasion and metastasis 1General receptor for phosphoinositides 1-associated scaffold proteinFERM and PDZ domain-containing protein 1tight junction protein ZO-1 isoform X2E3 ubiquitin-protein ligase LNX isoform X1Inactivation-no-after-potential D proteinInactivation-no-after-potential D proteinSAM domaincontaining proteinSC:10Regulating synaptic membrane exocytosis protein 1, putativePartitioning defective 6 homolog betaNitric oxide synthaseSC:2Periplasmic serine endoprotease DegP-likeZinc metalloproteaseZinc metalloproteasePeriplasmic proteaseSC:326S proteasome non-ATPase regulatory subunit 9SC:4Erbin isoform 7Periplasmic serine peptidase DegSSerine protease HTRA1serine protease HTRA2, mitochondrialPutative serine protease HTRA3Protease Do-like 1, chloroplasticSerine proteaseTricorn protease homologProbable serine protease PepD (Serine proteinase) (MTB32B)Protease Do-like 8, chloroplasticPutative serine protease HhoASC:5Glutamate receptor interacting protein 1Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 isoform 1MAGUK p55 subfamily member 6Syntrophin beta 1protein lap4 isoform X1PDZ domain-containing protein 11Pro-interleukin-16syntaxin-binding protein 4 isoform X1Synaptojanin-2-binding proteinNa(+)/H(+) exchange regulatory cofactor NHE-RF3 isoform X1PDZ and LIM domain protein 3SC:6Putative tight junction protein ZO-1Afadin isoform Aharmonin isoform X1harmonin isoform X1Partitioning defective 3 homolog BWhirlin amultiple PDZ domain protein isoform X1PDZ domain containing 7Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1PATJ, crumbs cell polarity complex componentMembrane associated guanylate kinase, WW and PDZ domain containing 2disks large homolog 5 isoform X1Cytohesin-interacting protein isoform X1Na(+)/H(+) exchange regulatory cofactor NHE-RF3inactivation-no-after-potential D proteinInactivation-no-after-potential D proteinSC:7Rho GTPase activating protein 21Whirlin aWhirlin aSC:8Na(+)/H(+) exchange regulatory cofactor NHE-RFInteracting with PRKCAmultiple PDZ domain protein isoform X1Tyrosine-protein phosphatase non-receptor type 13multiple PDZ domain protein isoform X2membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 isoform X1Pro-interleukin-16Ras-associating and dilute domain-containing proteinRHPN1 isoform 1Na(+)/H(+) exchange regulatory cofactor NHE-RF3SC:9Glutamate receptor interacting protein 1Disks large homolog 1 isoform 2Disks large homolog 4 isoform 2Disks large homolog 4 isoform 2Membrane associated guanylate kinase, WW and PDZ domain containing 1Amyloid beta A4 protein-binding family A memberPutative tight junction protein ZO-1Neurabin-1 isoform 1partitioning defective 3 homolog isoform X1Membrane associated guanylate kinase, WW and PDZ domain containing 1Segment polarity protein dishevelled homolog DVL-3peripheral plasma membrane protein CASK isoform X2Amyloid beta A4 protein-binding family A member 1SH3 and multiple ankyrin repeat domains protein 2LIM domain binding 3 isoform 1partitioning defective 3 homolog isoform X1Glutamate receptor interacting protein 1Glutamate receptor interacting protein 1rap guanine nucleotide exchange factor 2 isoform X1Golgi reassembly stacking protein 2Signal-induced proliferation-associated 1-like protein 1 isoform 2tight junction protein ZO-1 isoform X1Periplasmic serine endoprotease DegP-likeMultiple PDZ domain protein isoform X1Lin-7 homolog Bpartitioning defective 3 homolog isoform X2Syntenin-1 isoform X1Multiple PDZ domain protein isoform X1disks large homolog 1 isoform X1Multiple PDZ domain protein isoform X1FERM and PDZ domain-containing protein 4multiple PDZ domain protein isoform X1Golgi reassembly-stacking protein 2 isoform 1multiple PDZ domain protein isoform X1unconventional myosin-XVIIIa isoform X1Connector enhancer of kinase suppressor of Ras 2sorting nexin-27 isoform X2Peptidase, S41 familysyntenin-1 isoform X1Golgi-associated PDZ and coiled-coil motif-containing protein-likemultiple PDZ domain protein isoform X1Protein lin-7 homologSyntrophin gamma 1Ligand of Numb protein X 2Tail-specific proteaseTyrosine-protein phosphatase non-receptor type 13Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2Tyrosine-protein phosphatase non-receptor type 13MAGUK p55 subfamily member 5PDZ domain containing 7LIM domain kinase 1Putative pro-interleukin-16membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X2harmonin isoform X2Neuroblast differentiation-associated protein AHNAKMultiple PDZ domain protein isoform X1partitioning defective 3 homolog isoform X9Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2partitioning defective 3 homolog B isoform X2Uncharacterized protein, isoform ZMembrane associated guanylate kinase, WW and PDZ domain containing 2Ligand of numb-protein X 2Na(+)/H(+) exchange regulatory cofactor NHE-RF4DEP domain-containing mTOR-interacting protein isoform X1Piccolo presynaptic cytomatrix proteinPro-interleukin-16T cell lymphoma invasion and metastasis 2Tyrosine-protein phosphatase non-receptor type 13PDZ and LIM domain 2 (mystique)disks large homolog 5 isoform X1Caspase recruitment domain family member 11Synaptopodin 2-like aUncharacterized protein, isoform Csynaptopodin-2 isoform X1Multiple PDZ domain crumbs cell polarity complex componentPhosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1Membrane associated guanylate kinase, WW and PDZ domain containing 2Carboxyl-terminal-processing peptidase 1, chloroplasticmembrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 isoform X1PeriaxinStill life isoforms C/SIF type 2Scribbled, isoform Tmembrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X4PDZ domain containing 8 (Predicted)amyloid beta A4 precursor protein-binding family A member 3Tail-specific proteaserho GTPase-activating protein 100F isoform X1Ligand of numb-protein X 2whirlin isoform X1FERM and PDZ domain containing 3PDZ domain containing 7Caspase recruitment domain family member 14whirlin isoform X4Tyrosine-protein phosphatase non-receptor type 13FERM and PDZ domain containing 2Signal-induced proliferation-associated 1delphilin isoform X1disks large homolog 5 isoform X2Uncharacterized protein, isoform GPDZ domain containing 2whirlin isoform X2Golgi reassembly-stacking protein 2Uncharacterized protein, isoform BProtostome-specific GEF, isoform BBig bang, isoform FPDZ domain containing 2Big bang, isoform FUncharacterized protein, isoform KSerine proteaseUncharacterized protein, isoform JSyntrophin gamma 1ligand of Numb protein X 2Serine protease, DegP/HtrAInturned planar cell polarity proteinPeriplasmic serine endoprotease DegP-likeNa(+)/H(+) exchange regulatory cofactor NHE-RF4Uncharacterized protein, isoform Edelphilin isoform X1DiSHevelled relatedFife, isoform BSpoIVB peptidase 42 kDa isoformGlutamate receptor-interacting protein 1tax1-binding protein 3 isoform X2PDZ domain containing 3Patj, isoform BPDZ domain-containing protein 11tax1-binding protein 3 isoform X2Discs large MAGUK scaffold protein 5uncharacterized protein KIAA1614 homologUncharacterized protein, isoform FPDZ domain containing 2PDZ domain containing 2Uncharacterized protein, isoform Cuncharacterized protein LOC108099354 isoform X6Golgi re-assembly stacking protein 1USH1 protein network component harmoninArc, isoform AAHNAK2 isoform 1Golgi reassembly-stacking protein 2PDZ domain containing 2Rab3 interacting molecule, isoform RUncharacterized proteinUncharacterized protein, isoform EZO-1 (Zonula Occludens tight junctional protein) OrthologUncharacterized protein, isoform ARelated to GRH1-acetylated protein, involved in ER to Golgi transportProtein KINaseTyrosine-protein phosphataseuncharacterized protein LOC108093793 isoform X3AFaDin (Actin filament binding protein) homologGolgi reassembly-stacking protein 1 isoform X3Golgi reassembly-stacking protein 2 isoform X226S proteasome non-ATPase regulatory subunit 9LIM domain kinase 1Uncharacterized proteinUncharacterized protein, isoform ASip1Uncharacterized protein, isoform ADegP protease 7Protease Do-like 7membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1-like isoform X2Lap1, isoform BShroom family member 2MAGI (Membrane Associated Guanylate kinase Inverted) homologUncharacterized proteinCaspase recruitment domain family, member 14Multiple PDZ domain proteinProtease Do-like 9Uncharacterized protein, isoform BUncharacterized protein, isoform AUncharacterized proteinmembrane-associated guanylate kinase, WW and PDZ domain-containing protein 1-like isoform X3general receptor for phosphoinositides 1-associated scaffold protein isoform X2Golgi reassembly stacking proteinMultiple PDZ domain proteinMultiple PDZ domain proteinTail-specific proteaseUncharacterized protein, isoform AProtein CBR-STN-1DegP protease 7Multiple PDZ domain proteindisks large homolog 2Pdz domain containing protein, putativePartitioning defective protein 3Par-3 family cell polarity regulatorInactivation-no-after-potential D proteinGeneral secretion pathway protein Csorting nexin-27 isoform X2DEGP protease 2Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3Big bang, isoform CUsher syndrome 1CVaricose, isoform CUncharacterized protein, isoform ECaspase recruitment domain family, member 11LIM domain kinaseSerine proteaseMAGI family member, X-linked aGlutamate receptor-interacting protein 2-like ProteinPartitioning defective protein 3Partitioning defective protein 3Protein CBG16414Uncharacterized protein, isoform AAlpha-1-syntrophinRho GTPase activating protein at 19D, isoform DSerine protease PepAProtein lin-7 homolog AMAGI (Membrane Associated Guanylate kinase Inverted) homologPar-3 family cell polarity regulator betaMembrane metalloprotease ARASP, chloroplasticProtein CBG01035Endopeptidase LaGolgi re-assembly stacking protein 2GRASP65 homolog protein 1CBN-SHN-1 proteinRap guanine nucleotide exchange factorPro-apoptotic serine protease NMA111Pro-apoptotic serine protease NMA111Protein MET1, chloroplasticGlutamate receptor interacting protein 1MAGI (Membrane Associated Guanylate kinase Inverted) homologCarboxy-terminal processing proteaseAGAP011205-PAUncharacterized proteinUncharacterized proteinArc, isoform AProteasome regulatory subunit, putativePDZ and LIM domain 1MAGI family member, X-linked bMAGI family member, X-linked aLeucine-rich repeat-containing proteinPeriplasmic serine peptidase DegSSyntenin-1Protein inturnedFERM domain (Protein4.1-ezrin-radixin-moesin) familyCarboxy-terminal processing proteaseHtrA-like serine proteaseLeucine-rich repeat-containing proteinMembrane-associated guanylate kinase, WW and PDZ domain-containing proteinMitochondrial scaffolding protein 1NHERF (Mammalian Na/H Exchange Regulatory Factor) LikeSyndecan binding proteinGolgi reassembly stacking protein (GRASP homologue), putativeZinc metalloproteaseZinc metalloproteasePutative proteasome 26S non-ATPase subunit 9GD20482Uncharacterized protein, isoform ALIM domain kinase 1bMembrane associated guanylate kinase, WW and PDZ domain containing 3Rubredoxin family proteinPeriplasmic serine endoprotease DegP-likeMAGI (Membrane Associated Guanylate kinase Inverted) homologALP/Enigma encodingprotein inturned isoform X2protein lin-7 homolog BUncharacterized proteinLnx2 proteinSperm Meiosis PDZ domain containing proteinsPutative Golgi reassembly stacking protein (GRASP homologue)Protein lap1LIM domain kinase 1 isoform X3Periplasmic serine endoprotease DegP-likePeriplasmic serine endoprotease DegP-likeTail-specific proteaseDiscs large 5, isoform CGlutamate receptor-interacting protein 2aWD domain, G-beta repeat, putativeSlip1, isoform C
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FunFam 29: tight junction protein ZO-1 isoform X1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
10 A0A0G2K2P5 (/IPI) A0A2L2BH75 (/IPI) A0A2R8Q396 (/IPI) A0A2R8QMK9 (/IPI) E7F2W2 (/IPI) E9QET4 (/IPI) F1M4A0 (/IPI) O97758 (/IPI) P39447 (/IPI) Q07157 (/IPI)
Cell adhesion molecule binding GO:0050839
Interacting selectively and non-covalently with a cell adhesion molecule.
2 A0A0B4K6Y7 (/IPI) Q9VHK3 (/IPI)
Protein C-terminus binding GO:0008022
Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
1 A0A0G2K2P5 (/IPI)
Protein C-terminus binding GO:0008022
Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
1 P39447 (/ISO)
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
1 P39447 (/IPI)
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
1 Q07157 (/HDA)
Connexin binding GO:0071253
Interacting selectively and non-covalently with a connexin, any of a group of related proteins that assemble to form gap junctions.
1 P39447 (/IPI)
Showing 1 to 7 of 7 entries

There are 41 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Pigmentation GO:0043473
The accumulation of pigment in an organism, tissue or cell, either by increased deposition or by increased number of cells.
5 A0A2L2BH75 (/IGI) A0A2R8Q396 (/IGI) A0A2R8QMK9 (/IGI) E7F2W2 (/IGI) E9QET4 (/IGI)
Pigmentation GO:0043473
The accumulation of pigment in an organism, tissue or cell, either by increased deposition or by increased number of cells.
5 A0A2L2BH75 (/IMP) A0A2R8Q396 (/IMP) A0A2R8QMK9 (/IMP) E7F2W2 (/IMP) E9QET4 (/IMP)
Actin filament organization GO:0007015
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking.
4 H1UBK8 (/IMP) H1UBK9 (/IMP) Q56VX4 (/IMP) Q8I103 (/IMP)
Embryo development ending in birth or egg hatching GO:0009792
The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell.
4 H1UBK8 (/IGI) H1UBK9 (/IGI) Q56VX4 (/IGI) Q8I103 (/IGI)
Embryonic morphogenesis GO:0048598
The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants.
4 H1UBK8 (/IMP) H1UBK9 (/IMP) Q56VX4 (/IMP) Q8I103 (/IMP)
Compound eye morphogenesis GO:0001745
The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster.
2 A0A0B4K6Y7 (/IMP) Q9VHK3 (/IMP)
Dorsal closure GO:0007391
The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally.
2 A0A0B4K6Y7 (/IMP) Q9VHK3 (/IMP)
Synapse assembly GO:0007416
The aggregation, arrangement and bonding together of a set of components to form a synapse. This process ends when the synapse is mature (functional).
2 E7FE08 (/IMP) X1WHN9 (/IMP)
Open tracheal system development GO:0007424
The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster.
2 A0A0B4K6Y7 (/IMP) Q9VHK3 (/IMP)
Head involution GO:0008258
Movement of the anterior ectoderm to the interior of the embryo.
2 A0A0B4K6Y7 (/IMP) Q9VHK3 (/IMP)
Showing 1 to 10 of 41 entries

There are 40 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Bicellular tight junction GO:0005923
An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes.
13 A0A0G2K2P5 (/IDA) A0A2L2BH75 (/IDA) A0A2R8Q396 (/IDA) A0A2R8QMK9 (/IDA) E7F2W2 (/IDA) E9QET4 (/IDA) H1UBK8 (/IDA) H1UBK9 (/IDA) O97758 (/IDA) P39447 (/IDA)
(3 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
7 A0A087X0K9 (/IDA) A0A0B4K6Y7 (/IDA) G3V1L9 (/IDA) G5E9E7 (/IDA) P39447 (/IDA) Q07157 (/IDA) Q9VHK3 (/IDA)
Cell-cell adherens junction GO:0005913
An adherens junction which connects a cell to another cell.
7 A0A0B4K6Y7 (/IDA) H1UBK8 (/IDA) H1UBK9 (/IDA) P39447 (/IDA) Q56VX4 (/IDA) Q8I103 (/IDA) Q9VHK3 (/IDA)
Cell junction GO:0030054
A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix.
5 A0A087X0K9 (/IDA) G3V1L9 (/IDA) G5E9E7 (/IDA) P39447 (/IDA) Q07157 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
4 A0A087X0K9 (/IDA) G3V1L9 (/IDA) G5E9E7 (/IDA) Q07157 (/IDA)
Apical part of cell GO:0045177
The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.
4 A0A0B4K6Y7 (/IDA) P39447 (/IDA) Q07157 (/IDA) Q9VHK3 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 A0A0G2K2P5 (/IDA) P39447 (/IDA) Q07157 (/IDA)
Adherens junction GO:0005912
A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments.
3 A0A0B4K6Y7 (/IDA) P39447 (/IDA) Q9VHK3 (/IDA)
Gap junction GO:0005921
A cell-cell junction composed of pannexins or innexins and connexins, two different families of channel-forming proteins.
3 O97758 (/ISS) P39447 (/ISS) Q07157 (/ISS)
Basolateral plasma membrane GO:0016323
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
3 A0A0B4K6Y7 (/IDA) Q07157 (/IDA) Q9VHK3 (/IDA)
Showing 1 to 10 of 40 entries
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