The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 155: membrane-associated guanylate kinase, WW and PDZ d...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 26 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
3 O88382 (/IPI) Q86UL8 (/IPI) Q9WVQ1 (/IPI)
Phosphatase binding GO:0019902
Interacting selectively and non-covalently with any phosphatase.
3 G3QG32 (/ISS) O88382 (/ISS) Q9WVQ1 (/ISS)
Receptor signaling complex adaptor activity GO:0030159
Functions to provide a physical support for the assembly of a multiprotein receptor signaling complex.
3 G3QG32 (/ISS) O88382 (/ISS) Q9WVQ1 (/ISS)
Beta-1 adrenergic receptor binding GO:0031697
Interacting selectively and non-covalently with a beta-1 adrenergic receptor.
3 G3QG32 (/ISS) O88382 (/ISS) Q9WVQ1 (/ISS)
SMAD binding GO:0046332
Interacting selectively and non-covalently with a SMAD signaling protein.
3 G3QG32 (/ISS) O88382 (/ISS) Q86UL8 (/ISS)
Type II activin receptor binding GO:0070699
Interacting selectively and non-covalently with a type II activin receptor.
3 G3QG32 (/ISS) O88382 (/ISS) Q86UL8 (/ISS)
Kinesin binding GO:0019894
Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation.
1 O88382 (/IPI)
Kinesin binding GO:0019894
Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation.
1 Q9WVQ1 (/ISO)
Phosphatase binding GO:0019902
Interacting selectively and non-covalently with any phosphatase.
1 Q86UL8 (/IPI)
Phosphatase binding GO:0019902
Interacting selectively and non-covalently with any phosphatase.
1 Q9WVQ1 (/ISO)
Receptor signaling complex adaptor activity GO:0030159
Functions to provide a physical support for the assembly of a multiprotein receptor signaling complex.
1 Q86UL8 (/IDA)
Receptor signaling complex adaptor activity GO:0030159
Functions to provide a physical support for the assembly of a multiprotein receptor signaling complex.
1 Q9WVQ1 (/ISO)
Receptor signaling complex adaptor activity GO:0030159
Functions to provide a physical support for the assembly of a multiprotein receptor signaling complex.
1 Q9WVQ1 (/NAS)
Beta-1 adrenergic receptor binding GO:0031697
Interacting selectively and non-covalently with a beta-1 adrenergic receptor.
1 Q86UL8 (/IPI)
Beta-1 adrenergic receptor binding GO:0031697
Interacting selectively and non-covalently with a beta-1 adrenergic receptor.
1 Q9WVQ1 (/ISO)
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
1 O88382 (/IPI)
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
1 Q9WVQ1 (/ISO)
SMAD binding GO:0046332
Interacting selectively and non-covalently with a SMAD signaling protein.
1 Q9WVQ1 (/IPI)
Activin receptor binding GO:0070697
Interacting selectively and non-covalently with an activin receptor.
1 Q9WVQ1 (/IPI)
Type II activin receptor binding GO:0070699
Interacting selectively and non-covalently with a type II activin receptor.
1 Q9WVQ1 (/IPI)
Structural constituent of postsynaptic specialization GO:0098879
The action of a molecule that contributes to the structural integrity of a postsynaptic specialization.
1 O88382 (/IDA)
Structural constituent of postsynaptic specialization GO:0098879
The action of a molecule that contributes to the structural integrity of a postsynaptic specialization.
1 O88382 (/IMP)
Structural constituent of postsynaptic specialization GO:0098879
The action of a molecule that contributes to the structural integrity of a postsynaptic specialization.
1 Q9WVQ1 (/ISO)
Structural constituent of postsynaptic density GO:0098919
The action of a molecule that contributes to the structural integrity of a postsynaptic density.
1 O88382 (/IDA)
Structural constituent of postsynaptic density GO:0098919
The action of a molecule that contributes to the structural integrity of a postsynaptic density.
1 O88382 (/IMP)
Structural constituent of postsynaptic density GO:0098919
The action of a molecule that contributes to the structural integrity of a postsynaptic density.
1 Q9WVQ1 (/ISO)

There are 51 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of receptor internalization GO:0002092
Any process that activates or increases the frequency, rate or extent of receptor internalization.
3 G3QG32 (/ISS) O88382 (/ISS) Q9WVQ1 (/ISS)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
3 G3QG32 (/ISS) Q86UL8 (/ISS) Q9WVQ1 (/ISS)
Negative regulation of cell migration GO:0030336
Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.
3 G3QG32 (/ISS) Q86UL8 (/ISS) Q9WVQ1 (/ISS)
Positive regulation of phosphoprotein phosphatase activity GO:0032516
Any process that activates or increases the activity of a phosphoprotein phosphatase.
3 G3QG32 (/ISS) O88382 (/ISS) Q9WVQ1 (/ISS)
Negative regulation of activin receptor signaling pathway GO:0032926
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of any activin receptor signaling pathway.
3 G3QG32 (/ISS) O88382 (/ISS) Q86UL8 (/ISS)
Receptor clustering GO:0043113
The receptor metabolic process that results in grouping of a set of receptors at a cellular location, often to amplify the sensitivity of a signaling response.
3 G3QG32 (/ISS) Q86UL8 (/ISS) Q9WVQ1 (/ISS)
Protein heterooligomerization GO:0051291
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers that are not all identical. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
3 G3QG32 (/ISS) Q86UL8 (/ISS) Q9WVQ1 (/ISS)
Negative regulation of protein kinase B signaling GO:0051898
Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
3 G3QG32 (/ISS) O88382 (/ISS) Q9WVQ1 (/ISS)
SMAD protein signal transduction GO:0060395
The cascade of processes by which a signal interacts with a receptor, causing a change in the activity of a SMAD protein, and ultimately effecting a change in the functioning of the cell.
3 G3QG32 (/ISS) O88382 (/ISS) Q86UL8 (/ISS)
Mitotic cell cycle arrest GO:0071850
The process in which the mitotic cell cycle is halted during one of the normal phases (G1, S, G2, M).
3 G3QG32 (/ISS) Q86UL8 (/ISS) Q9WVQ1 (/ISS)
Glomerular visceral epithelial cell development GO:0072015
The process whose specific outcome is the progression of a glomerular visceral epithelial cell over time, from its formation to the mature structure. A glomerular visceral epithelial cell is a specialized epithelial cell that contains \feet\ that interdigitate with the \feet\ of other glomerular epithelial cells.
3 G3QG32 (/ISS) Q86UL8 (/ISS) Q9WVQ1 (/ISS)
Positive regulation of neuron projection development GO:0010976
Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
2 Q86UL8 (/ISS) Q9WVQ1 (/ISS)
Nerve growth factor signaling pathway GO:0038180
A series of molecular signals initiated by the binding of nerve growth factor (NGF) to a receptor on the surface of the target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2 Q86UL8 (/ISS) Q9WVQ1 (/ISS)
Pronephric glomerulus development GO:0039021
The progression of the glomerulus of the pronephric kidney over time from its initial formation until its mature state. The pronephric glomerulus is part of the pronephric nephron and is restricted to one body segment.
2 F1Q897 (/IMP) Q5VSD9 (/IMP)
Cellular response to nerve growth factor stimulus GO:1990090
A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nerve growth factor stimulus.
2 Q86UL8 (/ISS) Q9WVQ1 (/ISS)
Positive regulation of receptor internalization GO:0002092
Any process that activates or increases the frequency, rate or extent of receptor internalization.
1 Q86UL8 (/IDA)
Positive regulation of receptor internalization GO:0002092
Any process that activates or increases the frequency, rate or extent of receptor internalization.
1 Q9WVQ1 (/ISO)
Glomerular filtration GO:0003094
The process in which plasma is filtered through the glomerular membrane which consists of capillary endothelial cells, the basement membrane, and epithelial cells. The glomerular filtrate is the same as plasma except it has no significant amount of protein.
1 O88382 (/IC)
Planar cell polarity pathway involved in axis elongation GO:0003402
The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal to modulate cytoskeletal elements and control cell polarity that contributes to axis elongation.
1 Q86UL8 (/NAS)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
1 Q9WVQ1 (/IPI)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
1 O88382 (/IDA)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
1 Q9WVQ1 (/ISO)
Positive regulation of neuron projection development GO:0010976
Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
1 O88382 (/IMP)
Positive regulation of neuron projection development GO:0010976
Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
1 Q9WVQ1 (/ISO)
Negative regulation of cell migration GO:0030336
Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.
1 O88382 (/IDA)
Negative regulation of cell migration GO:0030336
Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.
1 Q9WVQ1 (/ISO)
Positive regulation of phosphoprotein phosphatase activity GO:0032516
Any process that activates or increases the activity of a phosphoprotein phosphatase.
1 Q86UL8 (/IDA)
Positive regulation of phosphoprotein phosphatase activity GO:0032516
Any process that activates or increases the activity of a phosphoprotein phosphatase.
1 Q9WVQ1 (/ISO)
Negative regulation of activin receptor signaling pathway GO:0032926
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of any activin receptor signaling pathway.
1 Q9WVQ1 (/IDA)
Nerve growth factor signaling pathway GO:0038180
A series of molecular signals initiated by the binding of nerve growth factor (NGF) to a receptor on the surface of the target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 O88382 (/IDA)
Nerve growth factor signaling pathway GO:0038180
A series of molecular signals initiated by the binding of nerve growth factor (NGF) to a receptor on the surface of the target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 Q9WVQ1 (/ISO)
Receptor clustering GO:0043113
The receptor metabolic process that results in grouping of a set of receptors at a cellular location, often to amplify the sensitivity of a signaling response.
1 O88382 (/IDA)
Receptor clustering GO:0043113
The receptor metabolic process that results in grouping of a set of receptors at a cellular location, often to amplify the sensitivity of a signaling response.
1 Q9WVQ1 (/ISO)
Protein heterooligomerization GO:0051291
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers that are not all identical. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
1 O88382 (/IDA)
Protein heterooligomerization GO:0051291
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers that are not all identical. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
1 Q9WVQ1 (/ISO)
Negative regulation of protein kinase B signaling GO:0051898
Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
1 Q86UL8 (/IDA)
Negative regulation of protein kinase B signaling GO:0051898
Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
1 Q9WVQ1 (/ISO)
SMAD protein signal transduction GO:0060395
The cascade of processes by which a signal interacts with a receptor, causing a change in the activity of a SMAD protein, and ultimately effecting a change in the functioning of the cell.
1 Q9WVQ1 (/IDA)
Mitotic cell cycle arrest GO:0071850
The process in which the mitotic cell cycle is halted during one of the normal phases (G1, S, G2, M).
1 O88382 (/IDA)
Mitotic cell cycle arrest GO:0071850
The process in which the mitotic cell cycle is halted during one of the normal phases (G1, S, G2, M).
1 Q9WVQ1 (/ISO)
Glomerular visceral epithelial cell development GO:0072015
The process whose specific outcome is the progression of a glomerular visceral epithelial cell over time, from its formation to the mature structure. A glomerular visceral epithelial cell is a specialized epithelial cell that contains \feet\ that interdigitate with the \feet\ of other glomerular epithelial cells.
1 O88382 (/IEP)
Neuroligin clustering involved in postsynaptic membrane assembly GO:0097118
The receptor clustering process involved in assembly of the postsynaptic membrane in which neuroligins are localized to distinct domains in the cell membrane. Neuroligins are neuronal cell surface proteins on the postsynaptic membrane that mediate synapse formation between neurons.
1 Q9WVQ1 (/IDA)
Regulation of neurotransmitter receptor localization to postsynaptic specialization membrane GO:0098696
Any process that modulates the frequency, rate or extent of neurotransmitter receptor localization to postsynaptic specialization membrane.
1 O88382 (/IDA)
Regulation of neurotransmitter receptor localization to postsynaptic specialization membrane GO:0098696
Any process that modulates the frequency, rate or extent of neurotransmitter receptor localization to postsynaptic specialization membrane.
1 O88382 (/IMP)
Regulation of neurotransmitter receptor localization to postsynaptic specialization membrane GO:0098696
Any process that modulates the frequency, rate or extent of neurotransmitter receptor localization to postsynaptic specialization membrane.
1 Q9WVQ1 (/ISO)
Regulation of synaptic membrane adhesion GO:0099179
Any process that modulates the frequency, rate or extent of adhesion between pre- and post-synaptic membranes.
1 O88382 (/IDA)
Regulation of synaptic membrane adhesion GO:0099179
Any process that modulates the frequency, rate or extent of adhesion between pre- and post-synaptic membranes.
1 O88382 (/IMP)
Regulation of synaptic membrane adhesion GO:0099179
Any process that modulates the frequency, rate or extent of adhesion between pre- and post-synaptic membranes.
1 Q9WVQ1 (/ISO)
Cellular response to nerve growth factor stimulus GO:1990090
A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nerve growth factor stimulus.
1 O88382 (/IDA)
Cellular response to nerve growth factor stimulus GO:1990090
A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nerve growth factor stimulus.
1 Q9WVQ1 (/ISO)
Positive regulation of synaptic vesicle clustering GO:2000809
Any process that activates or increases the frequency, rate or extent of synaptic vesicle clustering.
1 Q9WVQ1 (/IDA)

There are 41 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 G3QG32 (/ISS) O88382 (/ISS) Q9WVQ1 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 O88382 (/IDA) Q86UL8 (/IDA) Q9WVQ1 (/IDA)
Bicellular tight junction GO:0005923
An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes.
3 G3QG32 (/ISS) O88382 (/ISS) Q9WVQ1 (/ISS)
Postsynaptic density GO:0014069
An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
3 G3QG32 (/ISS) Q86UL8 (/ISS) Q9WVQ1 (/ISS)
Slit diaphragm GO:0036057
A specialized cell-cell junction found between the interdigitating foot processes of the glomerular epithelium (the podocytes) in the vertebrate kidney, which is adapted for facilitating glomerular filtration.
3 G3QG32 (/ISS) Q86UL8 (/ISS) Q9WVQ1 (/ISS)
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
3 G3QG32 (/ISS) Q86UL8 (/ISS) Q9WVQ1 (/ISS)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
3 G3QG32 (/ISS) Q86UL8 (/ISS) Q9WVQ1 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 G3QG32 (/ISS) O88382 (/ISS)
Late endosome GO:0005770
A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.
2 Q86UL8 (/ISS) Q9WVQ1 (/ISS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 Q86UL8 (/IDA) Q9WVQ1 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 G3QG32 (/ISS) O88382 (/ISS)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
2 O88382 (/IDA) Q9WVQ1 (/IDA)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
2 Q86UL8 (/ISS) Q9WVQ1 (/ISS)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
2 Q86UL8 (/ISS) Q9WVQ1 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q86UL8 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q9WVQ1 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q9WVQ1 (/ISO)
Late endosome GO:0005770
A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.
1 O88382 (/IDA)
Late endosome GO:0005770
A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.
1 Q9WVQ1 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q9WVQ1 (/ISO)
Bicellular tight junction GO:0005923
An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes.
1 Q86UL8 (/IDA)
Bicellular tight junction GO:0005923
An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes.
1 Q9WVQ1 (/ISO)
Postsynaptic density GO:0014069
An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
1 O88382 (/IDA)
Postsynaptic density GO:0014069
An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
1 Q9WVQ1 (/ISO)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
1 Q9WVQ1 (/ISO)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
1 O88382 (/IDA)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
1 Q9WVQ1 (/ISO)
Slit diaphragm GO:0036057
A specialized cell-cell junction found between the interdigitating foot processes of the glomerular epithelium (the podocytes) in the vertebrate kidney, which is adapted for facilitating glomerular filtration.
1 O88382 (/IDA)
Slit diaphragm GO:0036057
A specialized cell-cell junction found between the interdigitating foot processes of the glomerular epithelium (the podocytes) in the vertebrate kidney, which is adapted for facilitating glomerular filtration.
1 Q9WVQ1 (/ISO)
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
1 O88382 (/IDA)
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
1 Q9WVQ1 (/ISO)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
1 O88382 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
1 Q9WVQ1 (/ISO)
Extrinsic component of postsynaptic membrane GO:0098890
The component of the postsynaptic membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
1 O88382 (/IDA)
Extrinsic component of postsynaptic membrane GO:0098890
The component of the postsynaptic membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
1 Q9WVQ1 (/ISO)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
1 O88382 (/IDA)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
1 O88382 (/IMP)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
1 Q9WVQ1 (/ISO)
GABA-ergic synapse GO:0098982
A synapse that uses GABA as a neurotransmitter. These synapses are typically inhibitory.
1 O88382 (/IDA)
GABA-ergic synapse GO:0098982
A synapse that uses GABA as a neurotransmitter. These synapses are typically inhibitory.
1 O88382 (/IMP)
GABA-ergic synapse GO:0098982
A synapse that uses GABA as a neurotransmitter. These synapses are typically inhibitory.
1 Q9WVQ1 (/ISO)
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