The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.
FunFam 123: Na(+)/H(+) exchange regulatory cofactor NHE-RF4
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 15 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
6 | Q5T2W1 (/IPI) Q865P3 (/IPI) Q86UT5 (/IPI) Q99MJ6 (/IPI) Q9JIL4 (/IPI) Q9JJ40 (/IPI) |
|
Scavenger receptor binding GO:0005124
Interacting selectively and non-covalently with scavenger receptors, a family of proteins that are expressed on myeloid cells and are involved in the uptake of effete cellular components and foreign particles.
|
1 | Q9JJ40 (/IDA) |
|
Scavenger receptor binding GO:0005124
Interacting selectively and non-covalently with scavenger receptors, a family of proteins that are expressed on myeloid cells and are involved in the uptake of effete cellular components and foreign particles.
|
1 | Q9JIL4 (/ISO) |
|
Protein C-terminus binding GO:0008022
Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
|
1 | Q86UT5 (/IPI) |
|
Protein C-terminus binding GO:0008022
Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
|
1 | Q99MJ6 (/ISO) |
|
Ion channel inhibitor activity GO:0008200
Stops, prevents, or reduces the activity of an ion channel.
|
1 | Q86UT5 (/TAS) |
|
PDZ domain binding GO:0030165
Interacting selectively and non-covalently with a PDZ domain of a protein, a domain found in diverse signaling proteins.
|
1 | Q5T2W1 (/IPI) |
|
PDZ domain binding GO:0030165
Interacting selectively and non-covalently with a PDZ domain of a protein, a domain found in diverse signaling proteins.
|
1 | Q9JIL4 (/ISO) |
|
Guanylate cyclase inhibitor activity GO:0030251
Stops, prevents or reduces the activity of guanylate cyclase.
|
1 | Q86UT5 (/IDA) |
|
Guanylate cyclase inhibitor activity GO:0030251
Stops, prevents or reduces the activity of guanylate cyclase.
|
1 | Q99MJ6 (/ISO) |
|
Guanylate cyclase inhibitor activity GO:0030251
Stops, prevents or reduces the activity of guanylate cyclase.
|
1 | Q99MJ6 (/ISS) |
|
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
|
1 | Q9JJ40 (/IPI) |
|
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
|
1 | Q9JIL4 (/ISO) |
|
Ubiquitin-specific protease binding GO:1990381
Interacting selectively and non-covalently with a ubiquitin-specific protease.
|
1 | Q86UT5 (/IPI) |
|
Ubiquitin-specific protease binding GO:1990381
Interacting selectively and non-covalently with a ubiquitin-specific protease.
|
1 | Q99MJ6 (/ISO) |
There are 22 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Regulation of anion transport GO:0044070
Any process that modulates the frequency, rate or extent of the directed movement of anions, atoms or small molecules with a net negative charge into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
5 | Q3T0X8 (/ISS) Q5RCF7 (/ISS) Q5T2W1 (/ISS) Q865P3 (/ISS) Q9JJ40 (/ISS) |
|
Positive regulation of protein targeting to membrane GO:0090314
Any process that increases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein.
|
5 | Q3T0X8 (/ISS) Q5RCF7 (/ISS) Q5T2W1 (/ISS) Q865P3 (/ISS) Q9JJ40 (/ISS) |
|
In utero embryonic development GO:0001701
The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus.
|
1 | Q9JIL4 (/IMP) |
|
Ion transport GO:0006811
The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
1 | Q86UT5 (/NAS) |
|
Water transport GO:0006833
The directed movement of water (H2O) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
1 | Q86UT5 (/NAS) |
|
Receptor guanylyl cyclase signaling pathway GO:0007168
A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses guanylyl cyclase activity, and ending with regulation of a downstream cellular process, e.g. transcription.
|
1 | Q86UT5 (/IC) |
|
Cell population proliferation GO:0008283
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
|
1 | Q5T2W1 (/TAS) |
|
Response to toxic substance GO:0009636
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus.
|
1 | Q86UT5 (/TAS) |
|
Negative regulation of cGMP-mediated signaling GO:0010754
Any process that decreases the rate, frequency or extent of cGMP-mediated signaling. cGMP-mediated signaling is a series of molecular signals in which a cell uses cyclic GMP to convert an extracellular signal into a response.
|
1 | Q86UT5 (/IDA) |
|
Negative regulation of cGMP-mediated signaling GO:0010754
Any process that decreases the rate, frequency or extent of cGMP-mediated signaling. cGMP-mediated signaling is a series of molecular signals in which a cell uses cyclic GMP to convert an extracellular signal into a response.
|
1 | Q99MJ6 (/ISO) |
|
Carnitine transport GO:0015879
The directed movement of carnitine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carnitine is a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane.
|
1 | Q5T2W1 (/IDA) |
|
Carnitine transport GO:0015879
The directed movement of carnitine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carnitine is a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane.
|
1 | Q9JIL4 (/ISO) |
|
Cholesterol transport GO:0030301
The directed movement of cholesterol, cholest-5-en-3-beta-ol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
1 | Q9JJ40 (/NAS) |
|
Positive regulation of ion transmembrane transporter activity GO:0032414
Any process that activates or increases the activity of an ion transporter.
|
1 | Q5T2W1 (/IDA) |
|
Positive regulation of ion transmembrane transporter activity GO:0032414
Any process that activates or increases the activity of an ion transporter.
|
1 | Q9JIL4 (/ISO) |
|
Regulation of anion transport GO:0044070
Any process that modulates the frequency, rate or extent of the directed movement of anions, atoms or small molecules with a net negative charge into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
1 | Q9JIL4 (/IMP) |
|
Intracellular transport GO:0046907
The directed movement of substances within a cell.
|
1 | Q9JJ40 (/NAS) |
|
Protein localization to plasma membrane GO:0072659
A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.
|
1 | Q9JIL4 (/IMP) |
|
Positive regulation of protein targeting to membrane GO:0090314
Any process that increases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein.
|
1 | Q9JIL4 (/IMP) |
|
Positive regulation of cation transmembrane transport GO:1904064
Any process that activates or increases the frequency, rate or extent of cation transmembrane transport.
|
1 | Q5T2W1 (/IDA) |
|
Positive regulation of cation transmembrane transport GO:1904064
Any process that activates or increases the frequency, rate or extent of cation transmembrane transport.
|
1 | Q9JIL4 (/ISO) |
|
Xenobiotic detoxification by transmembrane export across the plasma membrane GO:1990961
A process that reduces or removes the toxicity of a xenobiotic by exporting it outside the cell.
|
1 | Q5T2W1 (/NAS) |
There are 20 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
5 | Q3T0X8 (/ISS) Q5RCF7 (/ISS) Q5T2W1 (/ISS) Q865P3 (/ISS) Q9JJ40 (/ISS) |
|
Brush border membrane GO:0031526
The portion of the plasma membrane surrounding the brush border.
|
5 | Q3T0X8 (/ISS) Q5RCF7 (/ISS) Q5T2W1 (/ISS) Q865P3 (/ISS) Q9JJ40 (/ISS) |
|
Brush border GO:0005903
The dense covering of microvilli on the apical surface of a epithelial cells in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell.
|
2 | Q86UT5 (/IDA) Q99MJ6 (/IDA) |
|
Apical part of cell GO:0045177
The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.
|
2 | Q86UT5 (/IDA) Q99MJ6 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q99MJ6 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q86UT5 (/TAS) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | Q9JIL4 (/IDA) |
|
Brush border GO:0005903
The dense covering of microvilli on the apical surface of a epithelial cells in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell.
|
1 | Q99MJ6 (/ISO) |
|
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
1 | Q99MJ6 (/IDA) |
|
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
|
1 | Q9JJ40 (/IDA) |
|
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
|
1 | Q9JIL4 (/ISO) |
|
Brush border membrane GO:0031526
The portion of the plasma membrane surrounding the brush border.
|
1 | Q9JIL4 (/IDA) |
|
Microvillus membrane GO:0031528
The portion of the plasma membrane surrounding a microvillus.
|
1 | Q9JJ40 (/IDA) |
|
Microvillus membrane GO:0031528
The portion of the plasma membrane surrounding a microvillus.
|
1 | Q9JIL4 (/ISO) |
|
Subapical complex GO:0035003
The most apical region of the lateral plasma membrane of an invertebrate epithelial cell. The subapical complex lies above the zonula adherens and the septate junction, and is comparable to the position of the tight junction of vertebrate cells.
|
1 | Q86UT5 (/IDA) |
|
Subapical complex GO:0035003
The most apical region of the lateral plasma membrane of an invertebrate epithelial cell. The subapical complex lies above the zonula adherens and the septate junction, and is comparable to the position of the tight junction of vertebrate cells.
|
1 | Q99MJ6 (/ISO) |
|
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
|
1 | Q9JJ40 (/IDA) |
|
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
|
1 | Q9JIL4 (/ISO) |
|
Apical part of cell GO:0045177
The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.
|
1 | Q99MJ6 (/ISO) |
|
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
1 | Q5T2W1 (/HDA) |
