The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 66: FERM and PDZ domain-containing protein 4

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 3 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
4 D3ZW88 (/IPI) Q14CM0 (/IPI) Q14CM0 (/IPI) Q5SYB0 (/IPI)
Phosphatidylinositol-4,5-bisphosphate binding GO:0005546
Interacting selectively and non-covalently with phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions.
2 Q14CM0 (/IDA) Q14CM0 (/IDA)
Phosphatidylinositol-4,5-bisphosphate binding GO:0005546
Interacting selectively and non-covalently with phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions.
1 A2AFR3 (/ISO)

There are 13 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of synapse structural plasticity GO:0051835
Any process that activates, maintains or increases the frequency, rate or extent of synaptic structural plasticity.
2 Q14CM0 (/IMP) Q14CM0 (/IMP)
Protein localization GO:0008104
Any process in which a protein is transported to, or maintained in, a specific location.
1 Q7SXQ6 (/IMP)
Regulation of G protein-coupled receptor signaling pathway GO:0008277
Any process that modulates the frequency, rate or extent of G protein-coupled receptor signaling pathway.
1 Q5SYB0 (/IMP)
Regulation of G protein-coupled receptor signaling pathway GO:0008277
Any process that modulates the frequency, rate or extent of G protein-coupled receptor signaling pathway.
1 A2AKB4 (/ISO)
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
1 Q5JV73 (/TAS)
Positive regulation of synapse structural plasticity GO:0051835
Any process that activates, maintains or increases the frequency, rate or extent of synaptic structural plasticity.
1 A2AFR3 (/ISO)
Positive regulation of synapse structural plasticity GO:0051835
Any process that activates, maintains or increases the frequency, rate or extent of synaptic structural plasticity.
1 A2AFR3 (/ISS)
Lens fiber cell morphogenesis GO:0070309
The process in which the structures of a lens fiber cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a lens fiber cell. A lens fiber cell is any of the elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye.
1 Q7SXQ6 (/IMP)
Establishment of protein localization to membrane GO:0090150
The directed movement of a protein to a specific location in a membrane.
1 Q5SYB0 (/IMP)
Establishment of protein localization to membrane GO:0090150
The directed movement of a protein to a specific location in a membrane.
1 A2AKB4 (/ISO)
Postsynaptic actin cytoskeleton organization GO:0098974
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the postsynaptic actin cytoskeleton.
1 D4A3K7 (/IDA)
Postsynaptic actin cytoskeleton organization GO:0098974
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the postsynaptic actin cytoskeleton.
1 D4A3K7 (/IMP)
Postsynaptic actin cytoskeleton organization GO:0098974
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the postsynaptic actin cytoskeleton.
1 A2AFR3 (/ISO)

There are 17 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
2 Q14CM0 (/IDA) Q14CM0 (/IDA)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
2 A2AFR3 (/ISO) A2AKB4 (/ISO)
Dendritic spine GO:0043197
A small, membranous protrusion from a dendrite that forms a postsynaptic compartment - typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable including \thin\, \stubby\, \mushroom\, and \branched\, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
2 Q14CM0 (/IDA) Q14CM0 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q5SYB0 (/IMP)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 A2AKB4 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q5JV73 (/TAS)
Postsynaptic density GO:0014069
An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
1 D4A3K7 (/IDA)
Postsynaptic density GO:0014069
An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
1 D4A3K7 (/IMP)
Postsynaptic density GO:0014069
An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
1 A2AFR3 (/ISO)
Secretory granule membrane GO:0030667
The lipid bilayer surrounding a secretory granule.
1 Q5JV73 (/TAS)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
1 Q5SYB0 (/IMP)
Dendritic spine GO:0043197
A small, membranous protrusion from a dendrite that forms a postsynaptic compartment - typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable including \thin\, \stubby\, \mushroom\, and \branched\, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
1 A2AFR3 (/ISO)
Dendritic spine GO:0043197
A small, membranous protrusion from a dendrite that forms a postsynaptic compartment - typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable including \thin\, \stubby\, \mushroom\, and \branched\, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
1 A2AFR3 (/ISS)
Tertiary granule membrane GO:0070821
The lipid bilayer surrounding a tertiary granule.
1 Q5JV73 (/TAS)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
1 D4A3K7 (/IDA)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
1 D4A3K7 (/IMP)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
1 A2AFR3 (/ISO)
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