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CATH Superfamily 2.30.29.30

Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 607: RTT106p Histone chaperone

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Double-stranded DNA binding GO:0003690
Interacting selectively and non-covalently with double-stranded DNA.
 4 P40161 (/IDA) P40161 (/IDA) P40161 (/IDA) P40161 (/IDA)
Double-stranded DNA binding GO:0003690
Interacting selectively and non-covalently with double-stranded DNA.
 4 P40161 (/IMP) P40161 (/IMP) P40161 (/IMP) P40161 (/IMP)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
 4 P40161 (/IPI) P40161 (/IPI) P40161 (/IPI) P40161 (/IPI)
Histone binding GO:0042393
Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity.
 4 P40161 (/IDA) P40161 (/IDA) P40161 (/IDA) P40161 (/IDA)
Histone binding GO:0042393
Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity.
 4 P40161 (/IMP) P40161 (/IMP) P40161 (/IMP) P40161 (/IMP)
Histone binding GO:0042393
Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity.
 4 P40161 (/IPI) P40161 (/IPI) P40161 (/IPI) P40161 (/IPI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
 4 P40161 (/IPI) P40161 (/IPI) P40161 (/IPI) P40161 (/IPI)

There are 7 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
 4 P40161 (/IMP) P40161 (/IMP) P40161 (/IMP) P40161 (/IMP)
DNA replication-dependent nucleosome assembly GO:0006335
The formation of nucleosomes on newly replicated DNA, coupled to strand elongation.
 4 P40161 (/IGI) P40161 (/IGI) P40161 (/IGI) P40161 (/IGI)
DNA replication-independent nucleosome assembly GO:0006336
The formation of nucleosomes outside the context of DNA replication.
 4 P40161 (/IMP) P40161 (/IMP) P40161 (/IMP) P40161 (/IMP)
Transcription elongation from RNA polymerase II promoter GO:0006368
The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II.
 4 P40161 (/IGI) P40161 (/IGI) P40161 (/IGI) P40161 (/IGI)
Transcription elongation from RNA polymerase II promoter GO:0006368
The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II.
 4 P40161 (/IMP) P40161 (/IMP) P40161 (/IMP) P40161 (/IMP)
Heterochromatin assembly involved in chromatin silencing GO:0070869
Any process that results in the assembly of chromatin into heterochromatin and contributes to chromatin silencing.
 4 P40161 (/IGI) P40161 (/IGI) P40161 (/IGI) P40161 (/IGI)
Heterochromatin assembly involved in chromatin silencing GO:0070869
Any process that results in the assembly of chromatin into heterochromatin and contributes to chromatin silencing.
 4 P40161 (/IMP) P40161 (/IMP) P40161 (/IMP) P40161 (/IMP)

There are 1 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
 4 P40161 (/HDA) P40161 (/HDA) P40161 (/HDA) P40161 (/HDA)