CATH Superfamily 2.30.29.30
Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
".
FunFam 58: focal adhesion kinase 1 isoform X1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 35 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
4 | O35346 (/IPI) P34152 (/IPI) Q00944 (/IPI) Q05397 (/IPI) |
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
|
3 | O35346 (/TAS) P34152 (/TAS) Q05397 (/TAS) |
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
|
2 | P34152 (/TAS) Q05397 (/TAS) |
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
|
2 | P34152 (/EXP) Q05397 (/EXP) |
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
|
2 | P34152 (/IDA) Q00944 (/IDA) |
Non-membrane spanning protein tyrosine kinase activity GO:0004715
Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein.
|
2 | O35346 (/ISS) P34152 (/ISS) |
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
2 | O35346 (/IPI) Q00944 (/IPI) |
Protease binding GO:0002020
Interacting selectively and non-covalently with any protease or peptidase.
|
1 | Q00944 (/IPI) |
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
|
1 | Q05397 (/IDA) |
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
|
1 | P34152 (/ISO) |
Showing 1 to 10 of 35 entries
There are 148 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein localization GO:0008104
Any process in which a protein is transported to, or maintained in, a specific location.
|
12 |
A0A0R4ICT0 (/IMP)
A0A2R8Q5G0 (/IMP)
A0A2R8QKV3 (/IMP)
A0A2R8QMF1 (/IMP)
A0A2R8RPC3 (/IMP)
A0A2R8RR02 (/IMP)
B3DGP9 (/IMP)
B3DKK9 (/IMP)
E7F1F9 (/IMP)
F1QT14 (/IMP)
(2 more) |
Lens fiber cell morphogenesis GO:0070309
The process in which the structures of a lens fiber cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a lens fiber cell. A lens fiber cell is any of the elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye.
|
9 | A0A2R8Q5G0 (/IMP) A0A2R8QKV3 (/IMP) A0A2R8QMF1 (/IMP) A0A2R8RPC3 (/IMP) A0A2R8RR02 (/IMP) B3DKK9 (/IMP) E7F1F9 (/IMP) F1QT14 (/IMP) Q98SN4 (/IMP) |
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
|
3 | P34152 (/IDA) Q00944 (/IDA) Q05397 (/IDA) |
Positive regulation of protein phosphorylation GO:0001934
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
|
2 | O35346 (/ISS) P34152 (/ISS) |
Integrin-mediated signaling pathway GO:0007229
A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
2 | O35346 (/IDA) Q05397 (/IDA) |
Integrin-mediated signaling pathway GO:0007229
A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
2 | O35346 (/ISS) P34152 (/ISS) |
Integrin-mediated signaling pathway GO:0007229
A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
2 | P34152 (/TAS) Q05397 (/TAS) |
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
|
2 | P34152 (/IMP) Q00944 (/IMP) |
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
|
2 | O35346 (/ISS) Q05397 (/ISS) |
Regulation of cell shape GO:0008360
Any process that modulates the surface configuration of a cell.
|
2 | O35346 (/ISS) P34152 (/ISS) |
Showing 1 to 10 of 148 entries
There are 39 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
|
6 | E7ESA6 (/IDA) H0YBP1 (/IDA) O35346 (/IDA) P34152 (/IDA) Q00944 (/IDA) Q05397 (/IDA) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
3 | O35346 (/IDA) P34152 (/IDA) Q05397 (/IDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
3 | E7ESA6 (/IDA) H0YBP1 (/IDA) Q05397 (/IDA) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | Q00944 (/IDA) Q05397 (/IDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | P34152 (/TAS) Q05397 (/TAS) |
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
|
2 | O35346 (/IDA) P34152 (/IDA) |
Sarcolemma GO:0042383
The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers.
|
2 | O35346 (/IDA) Q00944 (/IDA) |
Stress fiber GO:0001725
A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber.
|
1 | Q05397 (/IDA) |
Stress fiber GO:0001725
A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber.
|
1 | P34152 (/ISO) |
Cell GO:0005623
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
|
1 | Q00944 (/IDA) |
Showing 1 to 10 of 39 entries