CATH Superfamily 2.30.29.30
Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
".
FunFam 57: Fermitin family homolog 2 (Drosophila)
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 8 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
7 | Q8K1B8 (/IPI) Q8K1B8 (/IPI) Q96AC1 (/IPI) Q96AC1 (/IPI) Q96AC1 (/IPI) Q96AC1 (/IPI) Q96AC1 (/IPI) |
Phosphatidylinositol-3,4,5-trisphosphate binding GO:0005547
Interacting selectively and non-covalently with phosphatidylinositol-3,4,5-trisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3', 4' and 5' positions.
|
5 | Q96AC1 (/IDA) Q96AC1 (/IDA) Q96AC1 (/IDA) Q96AC1 (/IDA) Q96AC1 (/IDA) |
Integrin binding GO:0005178
Interacting selectively and non-covalently with an integrin.
|
3 | Q32LP0 (/ISS) Q86UX7 (/ISS) Q86UX7 (/ISS) |
Actin filament binding GO:0051015
Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
|
3 | P59113 (/IDA) Q8CIB5 (/IDA) Q8CIB5 (/IDA) |
Integrin binding GO:0005178
Interacting selectively and non-covalently with an integrin.
|
2 | Q8K1B8 (/IDA) Q8K1B8 (/IDA) |
Integrin binding GO:0005178
Interacting selectively and non-covalently with an integrin.
|
2 | Q8K1B8 (/IPI) Q8K1B8 (/IPI) |
Phosphatidylinositol-3,4,5-trisphosphate binding GO:0005547
Interacting selectively and non-covalently with phosphatidylinositol-3,4,5-trisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3', 4' and 5' positions.
|
2 | Q8CIB5 (/ISO) Q8CIB5 (/ISO) |
Phosphatidylinositol-3,4,5-trisphosphate binding GO:0005547
Interacting selectively and non-covalently with phosphatidylinositol-3,4,5-trisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3', 4' and 5' positions.
|
2 | Q8CIB5 (/ISS) Q8CIB5 (/ISS) |
Showing 1 to 8 of 8 entries
There are 64 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Integrin activation GO:0033622
The aggregation, arrangement and bonding together of an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits, that lead to the increased affinity of the integrin for its extracellular ligands.
|
11 |
Q86UX7 (/IMP)
Q86UX7 (/IMP)
Q8CIB5 (/IMP)
Q8CIB5 (/IMP)
Q8K1B8 (/IMP)
Q8K1B8 (/IMP)
Q96AC1 (/IMP)
Q96AC1 (/IMP)
Q96AC1 (/IMP)
Q96AC1 (/IMP)
(1 more) |
Substrate adhesion-dependent cell spreading GO:0034446
The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate.
|
8 | Q32LP0 (/ISS) Q8K1B8 (/ISS) Q8K1B8 (/ISS) Q96AC1 (/ISS) Q96AC1 (/ISS) Q96AC1 (/ISS) Q96AC1 (/ISS) Q96AC1 (/ISS) |
Cell-matrix adhesion GO:0007160
The binding of a cell to the extracellular matrix via adhesion molecules.
|
7 | Q8CIB5 (/IMP) Q8CIB5 (/IMP) Q96AC1 (/IMP) Q96AC1 (/IMP) Q96AC1 (/IMP) Q96AC1 (/IMP) Q96AC1 (/IMP) |
Integrin-mediated signaling pathway GO:0007229
A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
7 | Q86UX7 (/IMP) Q86UX7 (/IMP) Q96AC1 (/IMP) Q96AC1 (/IMP) Q96AC1 (/IMP) Q96AC1 (/IMP) Q96AC1 (/IMP) |
Cell-matrix adhesion GO:0007160
The binding of a cell to the extracellular matrix via adhesion molecules.
|
5 | Q96AC1 (/ISS) Q96AC1 (/ISS) Q96AC1 (/ISS) Q96AC1 (/ISS) Q96AC1 (/ISS) |
Transforming growth factor beta receptor signaling pathway GO:0007179
A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
5 | Q96AC1 (/IMP) Q96AC1 (/IMP) Q96AC1 (/IMP) Q96AC1 (/IMP) Q96AC1 (/IMP) |
Integrin-mediated signaling pathway GO:0007229
A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
5 | Q32LP0 (/ISS) Q8CIB5 (/ISS) Q8CIB5 (/ISS) Q8K1B8 (/ISS) Q8K1B8 (/ISS) |
Wnt signaling pathway GO:0016055
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state.
|
5 | Q96AC1 (/IMP) Q96AC1 (/IMP) Q96AC1 (/IMP) Q96AC1 (/IMP) Q96AC1 (/IMP) |
Integrin activation GO:0033622
The aggregation, arrangement and bonding together of an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits, that lead to the increased affinity of the integrin for its extracellular ligands.
|
5 | Q32LP0 (/ISS) Q8CIB5 (/ISS) Q8CIB5 (/ISS) Q8K1B8 (/ISS) Q8K1B8 (/ISS) |
Cell junction assembly GO:0034329
A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a cell junction.
|
5 | Q96AC1 (/TAS) Q96AC1 (/TAS) Q96AC1 (/TAS) Q96AC1 (/TAS) Q96AC1 (/TAS) |
Showing 1 to 10 of 64 entries
There are 29 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
|
14 |
A0A024R687 (/IDA)
A0A024R687 (/IDA)
A0A024R687 (/IDA)
A0A024R687 (/IDA)
A0A024R687 (/IDA)
A0A0U1RRM8 (/IDA)
H0YJ34 (/IDA)
H0YJ34 (/IDA)
P59113 (/IDA)
Q96AC1 (/IDA)
(4 more) |
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
13 |
A0A024R687 (/IDA)
A0A024R687 (/IDA)
A0A024R687 (/IDA)
A0A024R687 (/IDA)
A0A024R687 (/IDA)
A0A0U1RRM8 (/IDA)
H0YJ34 (/IDA)
H0YJ34 (/IDA)
Q96AC1 (/IDA)
Q96AC1 (/IDA)
(3 more) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
5 | Q96AC1 (/IDA) Q96AC1 (/IDA) Q96AC1 (/IDA) Q96AC1 (/IDA) Q96AC1 (/IDA) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
5 | Q96AC1 (/IDA) Q96AC1 (/IDA) Q96AC1 (/IDA) Q96AC1 (/IDA) Q96AC1 (/IDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
5 | Q96AC1 (/TAS) Q96AC1 (/TAS) Q96AC1 (/TAS) Q96AC1 (/TAS) Q96AC1 (/TAS) |
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
|
5 | Q96AC1 (/HDA) Q96AC1 (/HDA) Q96AC1 (/HDA) Q96AC1 (/HDA) Q96AC1 (/HDA) |
Extrinsic component of cytoplasmic side of plasma membrane GO:0031234
The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region.
|
5 | Q96AC1 (/IDA) Q96AC1 (/IDA) Q96AC1 (/IDA) Q96AC1 (/IDA) Q96AC1 (/IDA) |
Podosome GO:0002102
An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm.
|
3 | Q32LP0 (/ISS) Q86UX7 (/ISS) Q86UX7 (/ISS) |
Podosome GO:0002102
An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm.
|
2 | Q8K1B8 (/IDA) Q8K1B8 (/IDA) |
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
|
2 | Q86UX7 (/TAS) Q86UX7 (/TAS) |
Showing 1 to 10 of 29 entries