The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 53: Engulfment and cell motility protein 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
17 Q8BPU7 (/IPI) Q8BPU7 (/IPI) Q8MS15 (/IPI) Q92556 (/IPI) Q92556 (/IPI) Q92556 (/IPI) Q92556 (/IPI) Q92556 (/IPI) Q92556 (/IPI) Q92556 (/IPI)
(7 more)
SH3 domain binding GO:0017124
Interacting selectively and non-covalently with a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins.
8 Q92556 (/IPI) Q92556 (/IPI) Q92556 (/IPI) Q92556 (/IPI) Q92556 (/IPI) Q92556 (/IPI) Q92556 (/IPI) Q92556 (/IPI)
Receptor tyrosine kinase binding GO:0030971
Interacting selectively and non-covalently with a receptor that possesses protein tyrosine kinase activity.
5 Q96JJ3 (/IPI) Q96JJ3 (/IPI) Q96JJ3 (/IPI) Q96JJ3 (/IPI) Q96JJ3 (/IPI)
SH3 domain binding GO:0017124
Interacting selectively and non-covalently with a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins.
2 Q8BPU7 (/ISO) Q8BPU7 (/ISO)
Receptor tyrosine kinase binding GO:0030971
Interacting selectively and non-covalently with a receptor that possesses protein tyrosine kinase activity.
1 Q8BHL5 (/ISO)

There are 35 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038096
An Fc-gamma receptor signaling pathway that contributes to the endocytic engulfment of external particulate material by phagocytes.
13 Q92556 (/TAS) Q92556 (/TAS) Q92556 (/TAS) Q92556 (/TAS) Q92556 (/TAS) Q92556 (/TAS) Q92556 (/TAS) Q92556 (/TAS) Q96JJ3 (/TAS) Q96JJ3 (/TAS)
(3 more)
Vascular endothelial growth factor receptor signaling pathway GO:0048010
Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor (VEGFR) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription.
13 Q92556 (/TAS) Q92556 (/TAS) Q92556 (/TAS) Q92556 (/TAS) Q92556 (/TAS) Q92556 (/TAS) Q92556 (/TAS) Q92556 (/TAS) Q96JJ3 (/TAS) Q96JJ3 (/TAS)
(3 more)
Phagocytosis, engulfment GO:0006911
The internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis, including the membrane and cytoskeletal processes required, which involves one of three mechanisms: zippering of pseudopods around a target via repeated receptor-ligand interactions, sinking of the target directly into plasma membrane of the phagocytosing cell, or induced uptake via an enhanced membrane ruffling of the phagocytosing cell similar to macropinocytosis.
8 Q92556 (/IGI) Q92556 (/IGI) Q92556 (/IGI) Q92556 (/IGI) Q92556 (/IGI) Q92556 (/IGI) Q92556 (/IGI) Q92556 (/IGI)
Apoptotic process GO:0006915
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
8 Q92556 (/NAS) Q92556 (/NAS) Q92556 (/NAS) Q92556 (/NAS) Q92556 (/NAS) Q92556 (/NAS) Q92556 (/NAS) Q92556 (/NAS)
Rac protein signal transduction GO:0016601
A series of molecular signals within the cell that are mediated by a member of the Rac family of proteins switching to a GTP-bound active state.
8 Q92556 (/IGI) Q92556 (/IGI) Q92556 (/IGI) Q92556 (/IGI) Q92556 (/IGI) Q92556 (/IGI) Q92556 (/IGI) Q92556 (/IGI)
Actin cytoskeleton organization GO:0030036
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
8 Q92556 (/IGI) Q92556 (/IGI) Q92556 (/IGI) Q92556 (/IGI) Q92556 (/IGI) Q92556 (/IGI) Q92556 (/IGI) Q92556 (/IGI)
Cell motility GO:0048870
Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another.
8 Q92556 (/IGI) Q92556 (/IGI) Q92556 (/IGI) Q92556 (/IGI) Q92556 (/IGI) Q92556 (/IGI) Q92556 (/IGI) Q92556 (/IGI)
Regulation of defense response to virus by virus GO:0050690
Any viral process that modulates the frequency, rate, or extent of the antiviral response of the host cell or organism.
8 Q92556 (/TAS) Q92556 (/TAS) Q92556 (/TAS) Q92556 (/TAS) Q92556 (/TAS) Q92556 (/TAS) Q92556 (/TAS) Q92556 (/TAS)
Cell chemotaxis GO:0060326
The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
5 Q96JJ3 (/IMP) Q96JJ3 (/IMP) Q96JJ3 (/IMP) Q96JJ3 (/IMP) Q96JJ3 (/IMP)
Lymphangiogenesis GO:0001946
Lymph vessel formation when new vessels emerge from the proliferation of pre-existing vessels.
3 A0A0R4IHP8 (/IMP) A0A2R8RS12 (/IMP) Q6NV39 (/IMP)
Positive regulation of angiogenesis GO:0045766
Any process that activates or increases angiogenesis.
3 A0A0R4IHP8 (/IMP) A0A2R8RS12 (/IMP) Q6NV39 (/IMP)
Cilium assembly GO:0060271
The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.
3 A0A0R4IHP8 (/IGI) A0A2R8RS12 (/IGI) Q6NV39 (/IGI)
Cell chemotaxis GO:0060326
The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
3 A4FUD6 (/ISS) Q5RCC1 (/ISS) Q8BHL5 (/ISS)
Phagocytosis GO:0006909
A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.
2 Q8BPU7 (/IDA) Q8BPU7 (/IDA)
Phagocytosis, engulfment GO:0006911
The internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis, including the membrane and cytoskeletal processes required, which involves one of three mechanisms: zippering of pseudopods around a target via repeated receptor-ligand interactions, sinking of the target directly into plasma membrane of the phagocytosing cell, or induced uptake via an enhanced membrane ruffling of the phagocytosing cell similar to macropinocytosis.
2 Q8BPU7 (/ISO) Q8BPU7 (/ISO)
Phagocytosis, engulfment GO:0006911
The internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis, including the membrane and cytoskeletal processes required, which involves one of three mechanisms: zippering of pseudopods around a target via repeated receptor-ligand interactions, sinking of the target directly into plasma membrane of the phagocytosing cell, or induced uptake via an enhanced membrane ruffling of the phagocytosing cell similar to macropinocytosis.
2 Q8BPU7 (/ISS) Q8BPU7 (/ISS)
Actin filament organization GO:0007015
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking.
2 Q8MS15 (/IMP) Q9VKB2 (/IMP)
Border follicle cell migration GO:0007298
The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster.
2 Q8MS15 (/IMP) Q9VKB2 (/IMP)
Central nervous system development GO:0007417
The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.
2 Q8MS15 (/IMP) Q9VKB2 (/IMP)
Myoblast fusion GO:0007520
A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
2 Q8MS15 (/IMP) Q9VKB2 (/IMP)
Muscle attachment GO:0016203
The developmental process in which a skeletal muscle attaches to its target (such as bone or body wall).
2 Q8MS15 (/IGI) Q9VKB2 (/IGI)
Muscle attachment GO:0016203
The developmental process in which a skeletal muscle attaches to its target (such as bone or body wall).
2 Q8MS15 (/IMP) Q9VKB2 (/IMP)
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
2 Q8MS15 (/IGI) Q9VKB2 (/IGI)
Rac protein signal transduction GO:0016601
A series of molecular signals within the cell that are mediated by a member of the Rac family of proteins switching to a GTP-bound active state.
2 Q8BPU7 (/ISO) Q8BPU7 (/ISO)
Rac protein signal transduction GO:0016601
A series of molecular signals within the cell that are mediated by a member of the Rac family of proteins switching to a GTP-bound active state.
2 Q8BPU7 (/ISS) Q8BPU7 (/ISS)
Actin filament-based process GO:0030029
Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins.
2 Q8BPU7 (/IDA) Q8BPU7 (/IDA)
Actin cytoskeleton organization GO:0030036
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
2 Q8BPU7 (/ISO) Q8BPU7 (/ISO)
Actin cytoskeleton organization GO:0030036
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
2 Q8BPU7 (/ISS) Q8BPU7 (/ISS)
Cell motility GO:0048870
Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another.
2 Q8BPU7 (/ISO) Q8BPU7 (/ISO)
Cell motility GO:0048870
Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another.
2 Q8BPU7 (/ISS) Q8BPU7 (/ISS)
Activation of GTPase activity GO:0090630
Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP.
2 Q8MS15 (/IGI) Q9VKB2 (/IGI)
Positive regulation of JNK cascade GO:0046330
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade.
1 Q9VKB2 (/IDA)
Imaginal disc fusion, thorax closure GO:0046529
The joining of the parts of the wing imaginal discs, giving rise to the adult thorax.
1 Q9VKB2 (/IMP)
Vascular endothelial growth factor receptor signaling pathway GO:0048010
Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor (VEGFR) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 Q9VKB2 (/IMP)
Cell chemotaxis GO:0060326
The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
1 Q8BHL5 (/ISO)

There are 17 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
13 Q92556 (/TAS) Q92556 (/TAS) Q92556 (/TAS) Q92556 (/TAS) Q92556 (/TAS) Q92556 (/TAS) Q92556 (/TAS) Q92556 (/TAS) Q96JJ3 (/TAS) Q96JJ3 (/TAS)
(3 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
10 Q8MS15 (/IDA) Q92556 (/IDA) Q92556 (/IDA) Q92556 (/IDA) Q92556 (/IDA) Q92556 (/IDA) Q92556 (/IDA) Q92556 (/IDA) Q92556 (/IDA) Q9VKB2 (/IDA)
Guanyl-nucleotide exchange factor complex GO:0032045
A protein complex that stimulates the exchange of guanyl nucleotides associated with a GTPase.
10 Q8BPU7 (/IDA) Q8BPU7 (/IDA) Q92556 (/IDA) Q92556 (/IDA) Q92556 (/IDA) Q92556 (/IDA) Q92556 (/IDA) Q92556 (/IDA) Q92556 (/IDA) Q92556 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
8 Q5JVZ5 (/IDA) Q5JVZ5 (/IDA) Q5JVZ5 (/IDA) Q96JJ3 (/IDA) Q96JJ3 (/IDA) Q96JJ3 (/IDA) Q96JJ3 (/IDA) Q96JJ3 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
8 Q92556 (/IDA) Q92556 (/IDA) Q92556 (/IDA) Q92556 (/IDA) Q92556 (/IDA) Q92556 (/IDA) Q92556 (/IDA) Q92556 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
8 Q92556 (/HDA) Q92556 (/HDA) Q92556 (/HDA) Q92556 (/HDA) Q92556 (/HDA) Q92556 (/HDA) Q92556 (/HDA) Q92556 (/HDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
5 Q96JJ3 (/IDA) Q96JJ3 (/IDA) Q96JJ3 (/IDA) Q96JJ3 (/IDA) Q96JJ3 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 A4FUD6 (/ISS) Q5RCC1 (/ISS) Q8BHL5 (/ISS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
3 A4FUD6 (/ISS) Q5RCC1 (/ISS) Q8BHL5 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 Q8MS15 (/IDA) Q9VKB2 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q8BPU7 (/ISO) Q8BPU7 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q8BPU7 (/ISS) Q8BPU7 (/ISS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 Q8BPU7 (/ISO) Q8BPU7 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 Q8BPU7 (/ISS) Q8BPU7 (/ISS)
Guanyl-nucleotide exchange factor complex GO:0032045
A protein complex that stimulates the exchange of guanyl nucleotides associated with a GTPase.
2 Q8BPU7 (/ISO) Q8BPU7 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q8BHL5 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q8BHL5 (/ISO)
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