CATH Superfamily 2.30.29.30
Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
".
FunFam 526: Rho GTPase-activating protein
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 3 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
|
2 | P32873 (/IDA) P32873 (/IDA) |
|
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
|
2 | P32873 (/IGI) P32873 (/IGI) |
|
Phosphatidylinositol-3-phosphate binding GO:0032266
Interacting selectively and non-covalently with phosphatidylinositol-3-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' position.
|
2 | P32873 (/IDA) P32873 (/IDA) |
There are 5 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Establishment of cell polarity GO:0030010
The specification and formation of anisotropic intracellular organization or cell growth patterns.
|
2 | P32873 (/IMP) P32873 (/IMP) |
|
Septin ring organization GO:0031106
Control of the formation, spatial distribution, and breakdown of the septin ring.
|
2 | P32873 (/IGI) P32873 (/IGI) |
|
Negative regulation of Rho protein signal transduction GO:0035024
Any process that stops, prevents, or reduces the frequency, rate or extent of Rho protein signal transduction.
|
2 | P32873 (/IGI) P32873 (/IGI) |
|
Negative regulation of Rho protein signal transduction GO:0035024
Any process that stops, prevents, or reduces the frequency, rate or extent of Rho protein signal transduction.
|
2 | P32873 (/IMP) P32873 (/IMP) |
|
Negative regulation of Rho protein signal transduction GO:0035024
Any process that stops, prevents, or reduces the frequency, rate or extent of Rho protein signal transduction.
|
2 | P32873 (/IPI) P32873 (/IPI) |
There are 6 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Incipient cellular bud site GO:0000131
The portion of the budding yeast plasma membrane where a daughter cell will emerge. The yeast marks this spot with bud-site selection proteins before bud emergence occurs. Actin is polarized to this spot just prior to and during bud emergence.
|
2 | P32873 (/IDA) P32873 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | P32873 (/IDA) P32873 (/IDA) |
|
Cellular bud tip GO:0005934
The end of a cellular bud distal to the site of attachment to the mother cell.
|
2 | P32873 (/IDA) P32873 (/IDA) |
|
Cell cortex GO:0005938
The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
|
2 | P32873 (/IDA) P32873 (/IDA) |
|
Mating projection tip GO:0043332
The apex of the mating projection in unicellular fungi exposed to mating pheromone; site of polarized growth.
|
2 | P32873 (/HDA) P32873 (/HDA) |
|
Mating projection tip GO:0043332
The apex of the mating projection in unicellular fungi exposed to mating pheromone; site of polarized growth.
|
2 | P32873 (/IDA) P32873 (/IDA) |