CATH Superfamily 2.30.29.30
Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
".
FunFam 523: Protostome-specific GEF, isoform E
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 2 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Rho guanyl-nucleotide exchange factor activity GO:0005089
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
|
8 | E1JJB8 (/ISM) M9PGC1 (/ISM) M9PGJ2 (/ISM) M9PGV0 (/ISM) Q7K6U7 (/ISM) Q7KVY9 (/ISM) Q9W4Y9 (/ISM) Q9W4Z0 (/ISM) |
|
Calcium-dependent phospholipid binding GO:0005544
Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium.
|
8 | E1JJB8 (/ISM) M9PGC1 (/ISM) M9PGJ2 (/ISM) M9PGV0 (/ISM) Q7K6U7 (/ISM) Q7KVY9 (/ISM) Q9W4Y9 (/ISM) Q9W4Z0 (/ISM) |
There are 4 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Mushroom body development GO:0016319
The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells.
|
8 | E1JJB8 (/IGI) M9PGC1 (/IGI) M9PGJ2 (/IGI) M9PGV0 (/IGI) Q7K6U7 (/IGI) Q7KVY9 (/IGI) Q9W4Y9 (/IGI) Q9W4Z0 (/IGI) |
|
Regulation of actin filament polymerization GO:0030833
Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament.
|
8 | E1JJB8 (/IDA) M9PGC1 (/IDA) M9PGJ2 (/IDA) M9PGV0 (/IDA) Q7K6U7 (/IDA) Q7KVY9 (/IDA) Q9W4Y9 (/IDA) Q9W4Z0 (/IDA) |
|
Positive regulation of Rac protein signal transduction GO:0035022
Any process that activates or increases the frequency, rate or extent of Rac protein signal transduction.
|
8 | E1JJB8 (/IDA) M9PGC1 (/IDA) M9PGJ2 (/IDA) M9PGV0 (/IDA) Q7K6U7 (/IDA) Q7KVY9 (/IDA) Q9W4Y9 (/IDA) Q9W4Z0 (/IDA) |
|
Positive regulation of ruffle assembly GO:1900029
Any process that activates or increases the frequency, rate or extent of ruffle assembly.
|
8 | E1JJB8 (/IDA) M9PGC1 (/IDA) M9PGJ2 (/IDA) M9PGV0 (/IDA) Q7K6U7 (/IDA) Q7KVY9 (/IDA) Q9W4Y9 (/IDA) Q9W4Z0 (/IDA) |
There are 1 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q7KVY9 (/IDA) |