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CATH Superfamily 2.30.29.30

Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 516: Dos, isoform A

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 2 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
 2 Q9VZZ9 (/IPI) Q9VZZ9 (/IPI)
SH2 domain binding GO:0042169
Interacting selectively and non-covalently with a SH2 domain (Src homology 2) of a protein, a protein domain of about 100 amino-acid residues and belonging to the alpha + beta domain class.
 2 Q9VZZ9 (/IPI) Q9VZZ9 (/IPI)

There are 10 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
R7 cell fate commitment GO:0007465
The process in which the R7 photoreceptor commits to its cell fate. The R7 receptor contributes the central part of the rhabdomere in the apical parts of the ommatidium.
 2 Q9VZZ9 (/IGI) Q9VZZ9 (/IGI)
R7 cell fate commitment GO:0007465
The process in which the R7 photoreceptor commits to its cell fate. The R7 receptor contributes the central part of the rhabdomere in the apical parts of the ommatidium.
 2 Q9VZZ9 (/IMP) Q9VZZ9 (/IMP)
Torso signaling pathway GO:0008293
A series of molecular signals initiated by the binding of an extracellular ligand to torso (a receptor tyrosine kinase) on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
 2 Q9VZZ9 (/IGI) Q9VZZ9 (/IGI)
Torso signaling pathway GO:0008293
A series of molecular signals initiated by the binding of an extracellular ligand to torso (a receptor tyrosine kinase) on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
 2 Q9VZZ9 (/IMP) Q9VZZ9 (/IMP)
Anterior/posterior axis specification, embryo GO:0008595
The specification of the anterior/posterior axis of the embryo by the products of genes expressed maternally and genes expressed in the zygote.
 2 Q9VZZ9 (/TAS) Q9VZZ9 (/TAS)
Antimicrobial humoral response GO:0019730
An immune response against microbes mediated through a body fluid. Examples of this process are seen in the antimicrobial humoral response of Drosophila melanogaster and Mus musculus.
 2 Q9VZZ9 (/IMP) Q9VZZ9 (/IMP)
Photoreceptor cell development GO:0042461
Development of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light.
 2 Q9VZZ9 (/IMP) Q9VZZ9 (/IMP)
Sevenless signaling pathway GO:0045500
A series of molecular signals initiated by the binding of an extracellular ligand to sevenless (sev; a receptor tyrosine kinase) on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
 2 Q9VZZ9 (/IGI) Q9VZZ9 (/IGI)
Sevenless signaling pathway GO:0045500
A series of molecular signals initiated by the binding of an extracellular ligand to sevenless (sev; a receptor tyrosine kinase) on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
 2 Q9VZZ9 (/IMP) Q9VZZ9 (/IMP)
Regulation of Ras protein signal transduction GO:0046578
Any process that modulates the frequency, rate or extent of Ras protein signal transduction.
 2 Q9VZZ9 (/IMP) Q9VZZ9 (/IMP)

There are 2 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
 2 Q9VZZ9 (/IDA) Q9VZZ9 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
 2 Q9VZZ9 (/IDA) Q9VZZ9 (/IDA)