CATH Superfamily 2.30.29.30
Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
".
FunFam 466: carboxyl-terminal PDZ ligand of neuronal nitric ox...
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 1 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nitric-oxide synthase binding GO:0050998
Interacting selectively and non-covalently with the enzyme nitric-oxide synthase.
|
1 | H0VD63 (/IPI) |
There are 12 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
1 | H0VD63 (/IMP) |
|
Positive regulation of nitric oxide mediated signal transduction GO:0010750
Any process that increases the rate, frequency or extent of nitric oxide mediated signal transduction. Nitric oxide mediated signal transduction is a series of molecular signals mediated by the detection of nitric oxide (NO).
|
1 | H0VD63 (/IMP) |
|
Positive regulation of nitric oxide biosynthetic process GO:0045429
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.
|
1 | H0VD63 (/IMP) |
|
Protein stabilization GO:0050821
Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
|
1 | H0VD63 (/IC) |
|
Positive regulation of nitric-oxide synthase activity GO:0051000
Any process that activates or increases the activity of the enzyme nitric-oxide synthase.
|
1 | H0VD63 (/IMP) |
|
Regulation of ventricular cardiac muscle cell membrane repolarization GO:0060307
Any process that modulates the establishment or extent of a membrane potential in the polarizing direction towards the resting potential in a ventricular cardiomyocyte.
|
1 | H0VD63 (/IMP) |
|
Regulation of cardiac muscle cell action potential GO:0098901
Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a cardiac muscle cell. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.
|
1 | H0VD63 (/IMP) |
|
Positive regulation of potassium ion transmembrane transport GO:1901381
Any process that activates or increases the frequency, rate or extent of potassium ion transmembrane transport.
|
1 | H0VD63 (/IMP) |
|
Regulation of high voltage-gated calcium channel activity GO:1901841
Any process that modulates the frequency, rate or extent of high voltage-gated calcium channel activity.
|
1 | H0VD63 (/IMP) |
|
Positive regulation of delayed rectifier potassium channel activity GO:1902261
Any process that activates or increases the frequency, rate or extent of delayed rectifier potassium channel activity.
|
1 | H0VD63 (/IMP) |
|
Regulation of calcium ion transmembrane transport via high voltage-gated calcium channel GO:1902514
Any process that modulates the frequency, rate or extent of generation of calcium ion transmembrane transport via high voltage-gated calcium channel.
|
1 | H0VD63 (/IMP) |
|
Positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization GO:1903762
Any process that activates or increases the frequency, rate or extent of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization.
|
1 | H0VD63 (/IMP) |
There are 2 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Sarcolemma GO:0042383
The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers.
|
1 | H0VD63 (/IDA) |
|
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
|
1 | H0VD63 (/IDA) |
