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CATH Superfamily 2.30.29.30

Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 38: Myotubularin 1, isoform CRA_a

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Phosphatidylinositol-3-phosphatase. [EC: 3.1.3.64]
1-phosphatidyl-1D-myo-inositol 3-phosphate + H(2)O = 1-phosphatidyl- 1D-myo-inositol + phosphate.
  • This enzyme still works when the 2,3-bis(acyloxy)propyl group is removed, i.e., it hydrolyzes Ins(1,3)P(2) to Ins-1-P.
  • Formerly EC 3.1.3.65.
 47 A0A024RC06 A0A024RC06 A0A024RC06 A0A024RC06 A0A2R9BKD5 A0A2R9BKD5 A0A2R9BKD5 A0A2R9BKD5 A0A2R9CCM1 A0A2R9CCM1
(37 more...)
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase. [EC: 3.1.3.95]
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H(2)O = 1-phosphatidyl- 1D-myo-inositol 5-phosphate + phosphate.
  • The enzyme is found in both plants and animals.
  • It also has the activity of EC 3.1.3.64.
 47 A0A024RC06 A0A024RC06 A0A024RC06 A0A024RC06 A0A2R9BKD5 A0A2R9BKD5 A0A2R9BKD5 A0A2R9BKD5 A0A2R9CCM1 A0A2R9CCM1
(37 more...)
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