The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 371: Pebble, isoform B

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Rho guanyl-nucleotide exchange factor activity GO:0005089
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
11 A8JNN0 (/IDA) D2NUE8 (/IDA) D2NUE8 (/IDA) D2NUE8 (/IDA) D2NUE8 (/IDA) Q8IQ95 (/IDA) Q8IQ96 (/IDA) Q8IQ96 (/IDA) Q8IQ97 (/IDA) Q9U7D8 (/IDA)
(1 more)
Rho guanyl-nucleotide exchange factor activity GO:0005089
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
11 A8JNN0 (/ISS) D2NUE8 (/ISS) D2NUE8 (/ISS) D2NUE8 (/ISS) D2NUE8 (/ISS) Q8IQ95 (/ISS) Q8IQ96 (/ISS) Q8IQ96 (/ISS) Q8IQ97 (/ISS) Q9U7D8 (/ISS)
(1 more)
Rho GTPase binding GO:0017048
Interacting selectively and non-covalently with Rho protein, any member of the Rho subfamily of the Ras superfamily of monomeric GTPases. Proteins in the Rho subfamily are involved in relaying signals from cell-surface receptors to the actin cytoskeleton.
11 A8JNN0 (/IPI) D2NUE8 (/IPI) D2NUE8 (/IPI) D2NUE8 (/IPI) D2NUE8 (/IPI) Q8IQ95 (/IPI) Q8IQ96 (/IPI) Q8IQ96 (/IPI) Q8IQ97 (/IPI) Q9U7D8 (/IPI)
(1 more)
Semaphorin receptor binding GO:0030215
Interacting selectively and non-covalently with semaphorin receptors.
11 A8JNN0 (/IPI) D2NUE8 (/IPI) D2NUE8 (/IPI) D2NUE8 (/IPI) D2NUE8 (/IPI) Q8IQ95 (/IPI) Q8IQ96 (/IPI) Q8IQ96 (/IPI) Q8IQ97 (/IPI) Q9U7D8 (/IPI)
(1 more)
Rac guanyl-nucleotide exchange factor activity GO:0030676
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rac family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
11 A8JNN0 (/IDA) D2NUE8 (/IDA) D2NUE8 (/IDA) D2NUE8 (/IDA) D2NUE8 (/IDA) Q8IQ95 (/IDA) Q8IQ96 (/IDA) Q8IQ96 (/IDA) Q8IQ97 (/IDA) Q9U7D8 (/IDA)
(1 more)
Phosphatidylinositol phosphate binding GO:1901981
Interacting selectively and non-covalently with phosphatidylinositol phosphate.
11 A8JNN0 (/IDA) D2NUE8 (/IDA) D2NUE8 (/IDA) D2NUE8 (/IDA) D2NUE8 (/IDA) Q8IQ95 (/IDA) Q8IQ96 (/IDA) Q8IQ96 (/IDA) Q8IQ97 (/IDA) Q9U7D8 (/IDA)
(1 more)

There are 22 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Mitotic cytokinesis GO:0000281
A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells.
11 A8JNN0 (/IMP) D2NUE8 (/IMP) D2NUE8 (/IMP) D2NUE8 (/IMP) D2NUE8 (/IMP) Q8IQ95 (/IMP) Q8IQ96 (/IMP) Q8IQ96 (/IMP) Q8IQ97 (/IMP) Q9U7D8 (/IMP)
(1 more)
Actomyosin contractile ring assembly GO:0000915
The process of assembly of a ring composed of actin, myosin, and associated proteins that will function in cytokinesis.
11 A8JNN0 (/IMP) D2NUE8 (/IMP) D2NUE8 (/IMP) D2NUE8 (/IMP) D2NUE8 (/IMP) Q8IQ95 (/IMP) Q8IQ96 (/IMP) Q8IQ96 (/IMP) Q8IQ97 (/IMP) Q9U7D8 (/IMP)
(1 more)
Actomyosin contractile ring assembly GO:0000915
The process of assembly of a ring composed of actin, myosin, and associated proteins that will function in cytokinesis.
11 A8JNN0 (/TAS) D2NUE8 (/TAS) D2NUE8 (/TAS) D2NUE8 (/TAS) D2NUE8 (/TAS) Q8IQ95 (/TAS) Q8IQ96 (/TAS) Q8IQ96 (/TAS) Q8IQ97 (/TAS) Q9U7D8 (/TAS)
(1 more)
Meiosis I cytokinesis GO:0007110
A cell cycle process that results in the division of the cytoplasm of a cell after meiosis I, resulting in the separation of the original cell into two daughter cells.
11 A8JNN0 (/IMP) D2NUE8 (/IMP) D2NUE8 (/IMP) D2NUE8 (/IMP) D2NUE8 (/IMP) Q8IQ95 (/IMP) Q8IQ96 (/IMP) Q8IQ96 (/IMP) Q8IQ97 (/IMP) Q9U7D8 (/IMP)
(1 more)
Meiosis II cytokinesis GO:0007111
A cell cycle process that results in the division of the cytoplasm of a cell after meiosis II, resulting in the separation of the original cell into two daughter cells.
11 A8JNN0 (/IMP) D2NUE8 (/IMP) D2NUE8 (/IMP) D2NUE8 (/IMP) D2NUE8 (/IMP) Q8IQ95 (/IMP) Q8IQ96 (/IMP) Q8IQ96 (/IMP) Q8IQ97 (/IMP) Q9U7D8 (/IMP)
(1 more)
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
11 A8JNN0 (/IMP) D2NUE8 (/IMP) D2NUE8 (/IMP) D2NUE8 (/IMP) D2NUE8 (/IMP) Q8IQ95 (/IMP) Q8IQ96 (/IMP) Q8IQ96 (/IMP) Q8IQ97 (/IMP) Q9U7D8 (/IMP)
(1 more)
Defasciculation of motor neuron axon GO:0007415
Separation of a motor axon away from a bundle of axons known as a fascicle.
11 A8JNN0 (/IMP) D2NUE8 (/IMP) D2NUE8 (/IMP) D2NUE8 (/IMP) D2NUE8 (/IMP) Q8IQ95 (/IMP) Q8IQ96 (/IMP) Q8IQ96 (/IMP) Q8IQ97 (/IMP) Q9U7D8 (/IMP)
(1 more)
Malpighian tubule morphogenesis GO:0007443
The process in which the anatomical structures of the Malpighian tubule are generated and organized. This process takes place entirely during the embryonic phase. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which leads into the posterior part of the gut.
11 A8JNN0 (/IMP) D2NUE8 (/IMP) D2NUE8 (/IMP) D2NUE8 (/IMP) D2NUE8 (/IMP) Q8IQ95 (/IMP) Q8IQ96 (/IMP) Q8IQ96 (/IMP) Q8IQ97 (/IMP) Q9U7D8 (/IMP)
(1 more)
Mesoderm migration involved in gastrulation GO:0007509
The migration of mesodermal cells during gastrulation to help establish the multilayered body plan of the organism.
11 A8JNN0 (/IMP) D2NUE8 (/IMP) D2NUE8 (/IMP) D2NUE8 (/IMP) D2NUE8 (/IMP) Q8IQ95 (/IMP) Q8IQ96 (/IMP) Q8IQ96 (/IMP) Q8IQ97 (/IMP) Q9U7D8 (/IMP)
(1 more)
Mesodermal cell migration GO:0008078
The orderly movement of mesodermal cells from one site to another.
11 A8JNN0 (/IMP) D2NUE8 (/IMP) D2NUE8 (/IMP) D2NUE8 (/IMP) D2NUE8 (/IMP) Q8IQ95 (/IMP) Q8IQ96 (/IMP) Q8IQ96 (/IMP) Q8IQ97 (/IMP) Q9U7D8 (/IMP)
(1 more)
Regulation of cell shape GO:0008360
Any process that modulates the surface configuration of a cell.
11 A8JNN0 (/IMP) D2NUE8 (/IMP) D2NUE8 (/IMP) D2NUE8 (/IMP) D2NUE8 (/IMP) Q8IQ95 (/IMP) Q8IQ96 (/IMP) Q8IQ96 (/IMP) Q8IQ97 (/IMP) Q9U7D8 (/IMP)
(1 more)
Maintenance of protein location in cell GO:0032507
Any process in which a protein is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere.
11 A8JNN0 (/IMP) D2NUE8 (/IMP) D2NUE8 (/IMP) D2NUE8 (/IMP) D2NUE8 (/IMP) Q8IQ95 (/IMP) Q8IQ96 (/IMP) Q8IQ96 (/IMP) Q8IQ97 (/IMP) Q9U7D8 (/IMP)
(1 more)
Regulation of GTPase activity GO:0043087
Any process that modulates the rate of GTP hydrolysis by a GTPase.
11 A8JNN0 (/IGI) D2NUE8 (/IGI) D2NUE8 (/IGI) D2NUE8 (/IGI) D2NUE8 (/IGI) Q8IQ95 (/IGI) Q8IQ96 (/IGI) Q8IQ96 (/IGI) Q8IQ97 (/IGI) Q9U7D8 (/IGI)
(1 more)
Positive regulation of GTPase activity GO:0043547
Any process that activates or increases the activity of a GTPase.
11 A8JNN0 (/ISS) D2NUE8 (/ISS) D2NUE8 (/ISS) D2NUE8 (/ISS) D2NUE8 (/ISS) Q8IQ95 (/ISS) Q8IQ96 (/ISS) Q8IQ96 (/ISS) Q8IQ97 (/ISS) Q9U7D8 (/ISS)
(1 more)
Negative regulation of cell size GO:0045792
Any process that reduces cell size.
11 A8JNN0 (/IMP) D2NUE8 (/IMP) D2NUE8 (/IMP) D2NUE8 (/IMP) D2NUE8 (/IMP) Q8IQ95 (/IMP) Q8IQ96 (/IMP) Q8IQ96 (/IMP) Q8IQ97 (/IMP) Q9U7D8 (/IMP)
(1 more)
Regulation of axonogenesis GO:0050770
Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron.
11 A8JNN0 (/IGI) D2NUE8 (/IGI) D2NUE8 (/IGI) D2NUE8 (/IGI) D2NUE8 (/IGI) Q8IQ95 (/IGI) Q8IQ96 (/IGI) Q8IQ96 (/IGI) Q8IQ97 (/IGI) Q9U7D8 (/IGI)
(1 more)
Spindle assembly GO:0051225
The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart.
11 A8JNN0 (/IMP) D2NUE8 (/IMP) D2NUE8 (/IMP) D2NUE8 (/IMP) D2NUE8 (/IMP) Q8IQ95 (/IMP) Q8IQ96 (/IMP) Q8IQ96 (/IMP) Q8IQ97 (/IMP) Q9U7D8 (/IMP)
(1 more)
Negative regulation of canonical Wnt signaling pathway GO:0090090
Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
11 A8JNN0 (/IMP) D2NUE8 (/IMP) D2NUE8 (/IMP) D2NUE8 (/IMP) D2NUE8 (/IMP) Q8IQ95 (/IMP) Q8IQ96 (/IMP) Q8IQ96 (/IMP) Q8IQ97 (/IMP) Q9U7D8 (/IMP)
(1 more)
Mitotic actomyosin contractile ring assembly GO:1903475
Any actomyosin contractile ring assembly that is involved in mitotic cytokinesis.
11 A8JNN0 (/IMP) D2NUE8 (/IMP) D2NUE8 (/IMP) D2NUE8 (/IMP) D2NUE8 (/IMP) Q8IQ95 (/IMP) Q8IQ96 (/IMP) Q8IQ96 (/IMP) Q8IQ97 (/IMP) Q9U7D8 (/IMP)
(1 more)
Response to wounding GO:0009611
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.
1 Q8IQ97 (/IMP)
Actin cytoskeleton reorganization GO:0031532
A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins.
1 Q8IQ97 (/IMP)
Wound healing GO:0042060
The series of events that restore integrity to a damaged tissue, following an injury.
1 Q8IQ97 (/IMP)

There are 5 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
11 A8JNN0 (/IDA) D2NUE8 (/IDA) D2NUE8 (/IDA) D2NUE8 (/IDA) D2NUE8 (/IDA) Q8IQ95 (/IDA) Q8IQ96 (/IDA) Q8IQ96 (/IDA) Q8IQ97 (/IDA) Q9U7D8 (/IDA)
(1 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
11 A8JNN0 (/NAS) D2NUE8 (/NAS) D2NUE8 (/NAS) D2NUE8 (/NAS) D2NUE8 (/NAS) Q8IQ95 (/NAS) Q8IQ96 (/NAS) Q8IQ96 (/NAS) Q8IQ97 (/NAS) Q9U7D8 (/NAS)
(1 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
11 A8JNN0 (/HDA) D2NUE8 (/HDA) D2NUE8 (/HDA) D2NUE8 (/HDA) D2NUE8 (/HDA) Q8IQ95 (/HDA) Q8IQ96 (/HDA) Q8IQ96 (/HDA) Q8IQ97 (/HDA) Q9U7D8 (/HDA)
(1 more)
Cell cortex GO:0005938
The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
11 A8JNN0 (/IDA) D2NUE8 (/IDA) D2NUE8 (/IDA) D2NUE8 (/IDA) D2NUE8 (/IDA) Q8IQ95 (/IDA) Q8IQ96 (/IDA) Q8IQ96 (/IDA) Q8IQ97 (/IDA) Q9U7D8 (/IDA)
(1 more)
Cleavage furrow GO:0032154
The cleavage furrow is a plasma membrane invagination at the cell division site. The cleavage furrow begins as a shallow groove and eventually deepens to divide the cytoplasm.
11 A8JNN0 (/IDA) D2NUE8 (/IDA) D2NUE8 (/IDA) D2NUE8 (/IDA) D2NUE8 (/IDA) Q8IQ95 (/IDA) Q8IQ96 (/IDA) Q8IQ96 (/IDA) Q8IQ97 (/IDA) Q9U7D8 (/IDA)
(1 more)