CATH Superfamily 2.30.29.30
Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
".
FunFam 272: Rho guanine nucleotide exchange factor 15
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 4 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Rho guanyl-nucleotide exchange factor activity GO:0005089
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
|
16 |
E1BDY4 (/ISS)
F6V5A2 (/ISS)
F6VCK1 (/ISS)
F7IL25 (/ISS)
G1PAW4 (/ISS)
G1RG00 (/ISS)
G1TQ06 (/ISS)
G3R8J7 (/ISS)
G3SQE5 (/ISS)
G5B5F9 (/ISS)
(6 more) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
4 | A0A0G2JTU0 (/IPI) D3DTR7 (/IPI) O94989 (/IPI) O94989 (/IPI) |
|
Rho guanyl-nucleotide exchange factor activity GO:0005089
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
|
3 | O94989 (/IDA) O94989 (/IDA) Q5FWH6 (/IDA) |
|
Rho guanyl-nucleotide exchange factor activity GO:0005089
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
|
1 | Q5FWH6 (/ISO) |
There are 8 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Positive regulation of stress fiber assembly GO:0051496
Any process that activates or increases the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts.
|
17 |
E1BDY4 (/ISS)
F6V5A2 (/ISS)
F6VCK1 (/ISS)
F7IL25 (/ISS)
G1PAW4 (/ISS)
G1RG00 (/ISS)
G1TQ06 (/ISS)
G3R8J7 (/ISS)
G3SQE5 (/ISS)
G5B5F9 (/ISS)
(7 more) |
|
Negative regulation of synapse maturation GO:2000297
Any process that stops, prevents or reduces the frequency, rate or extent of synapse maturation.
|
16 |
E1BDY4 (/ISS)
F6V5A2 (/ISS)
F6VCK1 (/ISS)
F7IL25 (/ISS)
G1PAW4 (/ISS)
G1RG00 (/ISS)
G1TQ06 (/ISS)
G3R8J7 (/ISS)
G3SQE5 (/ISS)
G5B5F9 (/ISS)
(6 more) |
|
Regulation of catalytic activity GO:0050790
Any process that modulates the activity of an enzyme.
|
15 |
E1BDY4 (/ISS)
F6V5A2 (/ISS)
F6VCK1 (/ISS)
F7IL25 (/ISS)
G1PAW4 (/ISS)
G1RG00 (/ISS)
G1TQ06 (/ISS)
G3R8J7 (/ISS)
G3SQE5 (/ISS)
G5B5F9 (/ISS)
(5 more) |
|
Regulation of catalytic activity GO:0050790
Any process that modulates the activity of an enzyme.
|
2 | O94989 (/IDA) O94989 (/IDA) |
|
Regulation of catalytic activity GO:0050790
Any process that modulates the activity of an enzyme.
|
1 | Q5FWH6 (/ISO) |
|
Positive regulation of stress fiber assembly GO:0051496
Any process that activates or increases the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts.
|
1 | Q5FWH6 (/ISO) |
|
Retina vasculature morphogenesis in camera-type eye GO:0061299
The process in which the vasculature of the retina is generated and organized.
|
1 | Q5FWH6 (/IMP) |
|
Negative regulation of synapse maturation GO:2000297
Any process that stops, prevents or reduces the frequency, rate or extent of synapse maturation.
|
1 | Q5FWH6 (/IMP) |
There are 4 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
17 |
E1BDY4 (/ISS)
F6V5A2 (/ISS)
F6VCK1 (/ISS)
F7IL25 (/ISS)
G1PAW4 (/ISS)
G1RG00 (/ISS)
G1TQ06 (/ISS)
G3R8J7 (/ISS)
G3SQE5 (/ISS)
G5B5F9 (/ISS)
(7 more) |
|
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
|
16 |
E1BDY4 (/ISS)
F6V5A2 (/ISS)
F6VCK1 (/ISS)
F7IL25 (/ISS)
G1PAW4 (/ISS)
G1RG00 (/ISS)
G1TQ06 (/ISS)
G3R8J7 (/ISS)
G3SQE5 (/ISS)
G5B5F9 (/ISS)
(6 more) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q5FWH6 (/ISO) |
|
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
|
1 | Q5FWH6 (/IDA) |
