The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 270: Pleckstrin homology-like domain family A member 3

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 18 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Phosphatidylinositol-4,5-bisphosphate binding GO:0005546
Interacting selectively and non-covalently with phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions.
20 Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA)
(10 more)
Phosphatidylinositol-3,4,5-trisphosphate binding GO:0005547
Interacting selectively and non-covalently with phosphatidylinositol-3,4,5-trisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3', 4' and 5' positions.
20 Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA)
(10 more)
Phosphatidylinositol-5-phosphate binding GO:0010314
Interacting selectively and non-covalently with phosphatidylinositol-5-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 5' position.
20 Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA)
(10 more)
Phosphatidylinositol-3-phosphate binding GO:0032266
Interacting selectively and non-covalently with phosphatidylinositol-3-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' position.
20 Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA)
(10 more)
Phosphatidylinositol-3,4-bisphosphate binding GO:0043325
Interacting selectively and non-covalently with phosphatidylinositol-3,4-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 4' positions.
20 Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA)
(10 more)
Phosphatidylinositol-3,5-bisphosphate binding GO:0080025
Interacting selectively and non-covalently with phosphatidylinositol-3,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 5' positions.
20 Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA)
(10 more)
Phosphatidylinositol-4,5-bisphosphate binding GO:0005546
Interacting selectively and non-covalently with phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions.
10 Q5PQT7 (/ISS) Q8AW35 (/ISS) Q9WV95 (/ISS) Q9WV95 (/ISS) Q9WV95 (/ISS) Q9WV95 (/ISS) Q9WV95 (/ISS) Q9WV95 (/ISS) Q9WV95 (/ISS) Q9WV95 (/ISS)
Phosphatidylinositol-3,4,5-trisphosphate binding GO:0005547
Interacting selectively and non-covalently with phosphatidylinositol-3,4,5-trisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3', 4' and 5' positions.
10 Q5PQT7 (/ISS) Q8AW35 (/ISS) Q9WV95 (/ISS) Q9WV95 (/ISS) Q9WV95 (/ISS) Q9WV95 (/ISS) Q9WV95 (/ISS) Q9WV95 (/ISS) Q9WV95 (/ISS) Q9WV95 (/ISS)
Phosphatidylinositol-5-phosphate binding GO:0010314
Interacting selectively and non-covalently with phosphatidylinositol-5-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 5' position.
10 Q5PQT7 (/ISS) Q8AW35 (/ISS) Q9WV95 (/ISS) Q9WV95 (/ISS) Q9WV95 (/ISS) Q9WV95 (/ISS) Q9WV95 (/ISS) Q9WV95 (/ISS) Q9WV95 (/ISS) Q9WV95 (/ISS)
Phosphatidylinositol-3-phosphate binding GO:0032266
Interacting selectively and non-covalently with phosphatidylinositol-3-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' position.
10 Q5PQT7 (/ISS) Q8AW35 (/ISS) Q9WV95 (/ISS) Q9WV95 (/ISS) Q9WV95 (/ISS) Q9WV95 (/ISS) Q9WV95 (/ISS) Q9WV95 (/ISS) Q9WV95 (/ISS) Q9WV95 (/ISS)
Phosphatidylinositol-3,4-bisphosphate binding GO:0043325
Interacting selectively and non-covalently with phosphatidylinositol-3,4-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 4' positions.
10 Q5PQT7 (/ISS) Q8AW35 (/ISS) Q9WV95 (/ISS) Q9WV95 (/ISS) Q9WV95 (/ISS) Q9WV95 (/ISS) Q9WV95 (/ISS) Q9WV95 (/ISS) Q9WV95 (/ISS) Q9WV95 (/ISS)
Phosphatidylinositol-3,5-bisphosphate binding GO:0080025
Interacting selectively and non-covalently with phosphatidylinositol-3,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 5' positions.
10 Q5PQT7 (/ISS) Q8AW35 (/ISS) Q9WV95 (/ISS) Q9WV95 (/ISS) Q9WV95 (/ISS) Q9WV95 (/ISS) Q9WV95 (/ISS) Q9WV95 (/ISS) Q9WV95 (/ISS) Q9WV95 (/ISS)
Phosphatidylinositol-4,5-bisphosphate binding GO:0005546
Interacting selectively and non-covalently with phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions.
8 Q9WV95 (/ISO) Q9WV95 (/ISO) Q9WV95 (/ISO) Q9WV95 (/ISO) Q9WV95 (/ISO) Q9WV95 (/ISO) Q9WV95 (/ISO) Q9WV95 (/ISO)
Phosphatidylinositol-3,4,5-trisphosphate binding GO:0005547
Interacting selectively and non-covalently with phosphatidylinositol-3,4,5-trisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3', 4' and 5' positions.
8 Q9WV95 (/ISO) Q9WV95 (/ISO) Q9WV95 (/ISO) Q9WV95 (/ISO) Q9WV95 (/ISO) Q9WV95 (/ISO) Q9WV95 (/ISO) Q9WV95 (/ISO)
Phosphatidylinositol-5-phosphate binding GO:0010314
Interacting selectively and non-covalently with phosphatidylinositol-5-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 5' position.
8 Q9WV95 (/ISO) Q9WV95 (/ISO) Q9WV95 (/ISO) Q9WV95 (/ISO) Q9WV95 (/ISO) Q9WV95 (/ISO) Q9WV95 (/ISO) Q9WV95 (/ISO)
Phosphatidylinositol-3-phosphate binding GO:0032266
Interacting selectively and non-covalently with phosphatidylinositol-3-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' position.
8 Q9WV95 (/ISO) Q9WV95 (/ISO) Q9WV95 (/ISO) Q9WV95 (/ISO) Q9WV95 (/ISO) Q9WV95 (/ISO) Q9WV95 (/ISO) Q9WV95 (/ISO)
Phosphatidylinositol-3,4-bisphosphate binding GO:0043325
Interacting selectively and non-covalently with phosphatidylinositol-3,4-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 4' positions.
8 Q9WV95 (/ISO) Q9WV95 (/ISO) Q9WV95 (/ISO) Q9WV95 (/ISO) Q9WV95 (/ISO) Q9WV95 (/ISO) Q9WV95 (/ISO) Q9WV95 (/ISO)
Phosphatidylinositol-3,5-bisphosphate binding GO:0080025
Interacting selectively and non-covalently with phosphatidylinositol-3,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 5' positions.
8 Q9WV95 (/ISO) Q9WV95 (/ISO) Q9WV95 (/ISO) Q9WV95 (/ISO) Q9WV95 (/ISO) Q9WV95 (/ISO) Q9WV95 (/ISO) Q9WV95 (/ISO)

There are 19 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Anatomical structure morphogenesis GO:0009653
The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.
20 Q9Y5J5 (/TAS) Q9Y5J5 (/TAS) Q9Y5J5 (/TAS) Q9Y5J5 (/TAS) Q9Y5J5 (/TAS) Q9Y5J5 (/TAS) Q9Y5J5 (/TAS) Q9Y5J5 (/TAS) Q9Y5J5 (/TAS) Q9Y5J5 (/TAS)
(10 more)
Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771
A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage, and ends when the execution phase of apoptosis is triggered.
20 Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA)
(10 more)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
20 Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA)
(10 more)
Negative regulation of protein kinase B signaling GO:0051898
Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
20 Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA)
(10 more)
Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771
A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage, and ends when the execution phase of apoptosis is triggered.
10 Q5PQT7 (/ISS) Q8AW35 (/ISS) Q9WV95 (/ISS) Q9WV95 (/ISS) Q9WV95 (/ISS) Q9WV95 (/ISS) Q9WV95 (/ISS) Q9WV95 (/ISS) Q9WV95 (/ISS) Q9WV95 (/ISS)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
10 Q5PQT7 (/ISS) Q8AW35 (/ISS) Q9WV95 (/ISS) Q9WV95 (/ISS) Q9WV95 (/ISS) Q9WV95 (/ISS) Q9WV95 (/ISS) Q9WV95 (/ISS) Q9WV95 (/ISS) Q9WV95 (/ISS)
Negative regulation of protein kinase B signaling GO:0051898
Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
10 Q5PQT7 (/ISS) Q8AW35 (/ISS) Q9WV95 (/ISS) Q9WV95 (/ISS) Q9WV95 (/ISS) Q9WV95 (/ISS) Q9WV95 (/ISS) Q9WV95 (/ISS) Q9WV95 (/ISS) Q9WV95 (/ISS)
Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771
A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage, and ends when the execution phase of apoptosis is triggered.
8 Q9WV95 (/ISO) Q9WV95 (/ISO) Q9WV95 (/ISO) Q9WV95 (/ISO) Q9WV95 (/ISO) Q9WV95 (/ISO) Q9WV95 (/ISO) Q9WV95 (/ISO)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
8 Q9WV95 (/ISO) Q9WV95 (/ISO) Q9WV95 (/ISO) Q9WV95 (/ISO) Q9WV95 (/ISO) Q9WV95 (/ISO) Q9WV95 (/ISO) Q9WV95 (/ISO)
Negative regulation of protein kinase B signaling GO:0051898
Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
8 Q9WV95 (/ISO) Q9WV95 (/ISO) Q9WV95 (/ISO) Q9WV95 (/ISO) Q9WV95 (/ISO) Q9WV95 (/ISO) Q9WV95 (/ISO) Q9WV95 (/ISO)
Placenta development GO:0001890
The process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin.
1 O08969 (/IDA)
Apoptotic process GO:0006915
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
1 Q53GA4 (/TAS)
Animal organ morphogenesis GO:0009887
Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
1 O08969 (/IMP)
Regulation of gene expression GO:0010468
Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 O08969 (/IDA)
Regulation of cell migration GO:0030334
Any process that modulates the frequency, rate or extent of cell migration.
1 O08969 (/IDA)
Regulation of embryonic development GO:0045995
Any process that modulates the frequency, rate or extent of embryonic development.
1 O08969 (/IDA)
Regulation of spongiotrophoblast cell proliferation GO:0060721
Any process that modulates the rate, frequency or extent of spongiotrophoblast cell proliferation.
1 O08969 (/IMP)
Regulation of glycogen metabolic process GO:0070873
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving glycogen.
1 O08969 (/IDA)
Regulation of growth hormone activity GO:1903547
Any process that modulates the frequency, rate or extent of growth hormone activity.
1 O08969 (/IMP)

There are 4 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
20 Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA) Q9Y5J5 (/IDA)
(10 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
10 Q5PQT7 (/ISS) Q8AW35 (/ISS) Q9WV95 (/ISS) Q9WV95 (/ISS) Q9WV95 (/ISS) Q9WV95 (/ISS) Q9WV95 (/ISS) Q9WV95 (/ISS) Q9WV95 (/ISS) Q9WV95 (/ISS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
8 Q9WV95 (/ISO) Q9WV95 (/ISO) Q9WV95 (/ISO) Q9WV95 (/ISO) Q9WV95 (/ISO) Q9WV95 (/ISO) Q9WV95 (/ISO) Q9WV95 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 O08969 (/TAS)
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