The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 262: Disabled, isoform F

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 4 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
4 A5JYR4 (/IPI) Q8I4G9 (/IPI) Q8I4H0 (/IPI) Q9U3A6 (/IPI)
Clathrin heavy chain binding GO:0032050
Interacting selectively and non-covalently with a clathrin heavy chain.
4 A5JYR4 (/IDA) Q8I4G9 (/IDA) Q8I4H0 (/IDA) Q9U3A6 (/IDA)
Sevenless binding GO:0005118
Interacting selectively and non-covalently with the sevenless (sev) protein, a receptor tyrosine kinase.
1 P98081 (/IPI)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 P98081 (/IPI)

There are 18 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nematode larval development GO:0002119
The process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew.
4 A5JYR4 (/IGI) Q8I4G9 (/IGI) Q8I4H0 (/IGI) Q9U3A6 (/IGI)
Receptor-mediated endocytosis GO:0006898
An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles.
4 A5JYR4 (/IMP) Q8I4G9 (/IMP) Q8I4H0 (/IMP) Q9U3A6 (/IMP)
Protein localization GO:0008104
Any process in which a protein is transported to, or maintained in, a specific location.
4 A5JYR4 (/IMP) Q8I4G9 (/IMP) Q8I4H0 (/IMP) Q9U3A6 (/IMP)
Protein secretion GO:0009306
The controlled release of proteins from a cell.
4 A5JYR4 (/IMP) Q8I4G9 (/IMP) Q8I4H0 (/IMP) Q9U3A6 (/IMP)
Embryo development ending in birth or egg hatching GO:0009792
The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell.
4 A5JYR4 (/IGI) Q8I4G9 (/IGI) Q8I4H0 (/IGI) Q9U3A6 (/IGI)
Oviposition GO:0018991
The deposition of eggs (either fertilized or not) upon a surface or into a medium such as water.
4 A5JYR4 (/IMP) Q8I4G9 (/IMP) Q8I4H0 (/IMP) Q9U3A6 (/IMP)
Positive regulation of growth rate GO:0040010
Any process that increases the rate of growth of all or part of an organism.
4 A5JYR4 (/IMP) Q8I4G9 (/IMP) Q8I4H0 (/IMP) Q9U3A6 (/IMP)
Positive regulation of locomotion GO:0040017
Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism.
4 A5JYR4 (/IMP) Q8I4G9 (/IMP) Q8I4H0 (/IMP) Q9U3A6 (/IMP)
Ecdysis, collagen and cuticulin-based cuticle GO:0042395
The shedding of the old collagen and cuticulin-based cuticle fragments during the molting cycle. Examples of this process are found in invertebrates.
4 A5JYR4 (/IMP) Q8I4G9 (/IMP) Q8I4H0 (/IMP) Q9U3A6 (/IMP)
Positive regulation of endocytosis GO:0045807
Any process that activates or increases the frequency, rate or extent of endocytosis.
3 Q8I4G9 (/IDA) Q8I4H0 (/IDA) Q9U3A6 (/IDA)
Cellularization GO:0007349
The separation of a multi-nucleate cell or syncytium into individual cells. An example of this is found in Drosophila melanogaster embryo development.
1 P98081 (/IMP)
Dorsal closure GO:0007391
The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally.
1 P98081 (/IMP)
Motor neuron axon guidance GO:0008045
The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues.
1 P98081 (/IMP)
Compound eye photoreceptor development GO:0042051
The process whose specific outcome is the progression of a light-responsive receptor in the compound eye over time, from its formation to the mature structure.
1 P98081 (/IMP)
Positive regulation of endocytosis GO:0045807
Any process that activates or increases the frequency, rate or extent of endocytosis.
1 A5JYR4 (/IMP)
Positive regulation of sevenless signaling pathway GO:0045874
Any process that activates or increases the frequency, rate or extent of the sevenless signaling pathway.
1 P98081 (/IGI)
Synaptic vesicle endocytosis GO:0048488
A vesicle-mediated transport process, in which the synaptic vesicle membrane constituents are retrieved from the presynaptic membrane on the axon terminal after neurotransmitter secretion by exocytosis. Synaptic vesicle endocytosis can occur via clathrin-dependent and clathrin-independent mechanisms.
1 P98081 (/IDA)
Clathrin-dependent endocytosis GO:0072583
An endocytosis process that begins when material is taken up into clathrin-coated pits, which then pinch off to form clathrin-coated endocytic vesicles.
1 P98081 (/IDA)

There are 7 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
4 A5JYR4 (/IDA) Q8I4G9 (/IDA) Q8I4H0 (/IDA) Q9U3A6 (/IDA)
Golgi-associated vesicle GO:0005798
Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell.
4 A5JYR4 (/IDA) Q8I4G9 (/IDA) Q8I4H0 (/IDA) Q9U3A6 (/IDA)
Cell cortex GO:0005938
The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
4 A5JYR4 (/IDA) Q8I4G9 (/IDA) Q8I4H0 (/IDA) Q9U3A6 (/IDA)
Extrinsic component of cytoplasmic side of plasma membrane GO:0031234
The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region.
4 A5JYR4 (/IDA) Q8I4G9 (/IDA) Q8I4H0 (/IDA) Q9U3A6 (/IDA)
Vesicle GO:0031982
Any small, fluid-filled, spherical organelle enclosed by membrane.
4 A5JYR4 (/IDA) Q8I4G9 (/IDA) Q8I4H0 (/IDA) Q9U3A6 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P98081 (/IDA)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
1 P98081 (/IDA)