CATH Superfamily 2.30.29.30
Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
".
FunFam 26: Arf-GAP with coiled-coil, ANK repeat and PH domain...
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 7 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
|
4 | A2ADA6 (/IMP) Q3UH98 (/IMP) Q4QQN0 (/IMP) Q6NXL5 (/IMP) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
2 | Q15027 (/IPI) Q6ZQK5 (/IPI) |
|
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
|
1 | Q7KS50 (/ISM) |
|
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
|
1 | Q6ZQK5 (/ISO) |
|
Phospholipid binding GO:0005543
Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester.
|
1 | Q7KS50 (/ISS) |
|
Rab GTPase binding GO:0017137
Interacting selectively and non-covalently with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases.
|
1 | Q6ZQK5 (/IPI) |
|
Phosphatidylinositol-3,5-bisphosphate binding GO:0080025
Interacting selectively and non-covalently with phosphatidylinositol-3,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 5' positions.
|
1 | Q6ZQK5 (/IDA) |
There are 11 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Endocytic recycling GO:0032456
The directed movement of membrane-bounded vesicles from recycling endosomes back to the plasma membrane where they are recycled for further rounds of transport.
|
7 | Q15057 (/ISS) Q15057 (/ISS) Q15057 (/ISS) Q15057 (/ISS) Q5ZK62 (/ISS) Q6IVG4 (/ISS) Q6ZQK5 (/ISS) |
|
Cellular response to nerve growth factor stimulus GO:1990090
A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nerve growth factor stimulus.
|
7 | Q15057 (/ISS) Q15057 (/ISS) Q15057 (/ISS) Q15057 (/ISS) Q5ZK62 (/ISS) Q6IVG4 (/ISS) Q6ZQK5 (/ISS) |
|
Neuron migration GO:0001764
The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
|
4 | A2ADA6 (/IMP) Q3UH98 (/IMP) Q4QQN0 (/IMP) Q6NXL5 (/IMP) |
|
Regulation of neuron projection development GO:0010975
Any process that modulates the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
|
4 | A2ADA6 (/IMP) Q3UH98 (/IMP) Q4QQN0 (/IMP) Q6NXL5 (/IMP) |
|
Cell morphogenesis GO:0000902
The developmental process in which the size or shape of a cell is generated and organized.
|
1 | Q7KS50 (/IMP) |
|
Actin filament-based process GO:0030029
Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins.
|
1 | Q6ZQK5 (/ISO) |
|
Endocytic recycling GO:0032456
The directed movement of membrane-bounded vesicles from recycling endosomes back to the plasma membrane where they are recycled for further rounds of transport.
|
1 | Q5FVC7 (/IMP) |
|
Endocytic recycling GO:0032456
The directed movement of membrane-bounded vesicles from recycling endosomes back to the plasma membrane where they are recycled for further rounds of transport.
|
1 | Q6ZQK5 (/ISO) |
|
Regulation of GTPase activity GO:0043087
Any process that modulates the rate of GTP hydrolysis by a GTPase.
|
1 | Q7KS50 (/ISM) |
|
Cellular response to nerve growth factor stimulus GO:1990090
A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nerve growth factor stimulus.
|
1 | Q5FVC7 (/IDA) |
|
Cellular response to nerve growth factor stimulus GO:1990090
A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nerve growth factor stimulus.
|
1 | Q6ZQK5 (/ISO) |
There are 7 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Endosome membrane GO:0010008
The lipid bilayer surrounding an endosome.
|
7 | Q15057 (/ISS) Q15057 (/ISS) Q15057 (/ISS) Q15057 (/ISS) Q5ZK62 (/ISS) Q6IVG4 (/ISS) Q6ZQK5 (/ISS) |
|
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
5 | Q15027 (/HDA) Q15057 (/HDA) Q15057 (/HDA) Q15057 (/HDA) Q15057 (/HDA) |
|
Growth cone GO:0030426
The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic.
|
4 | A2ADA6 (/IDA) Q3UH98 (/IDA) Q4QQN0 (/IDA) Q6NXL5 (/IDA) |
|
Ruffle GO:0001726
Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork.
|
1 | Q6ZQK5 (/ISO) |
|
Endosome membrane GO:0010008
The lipid bilayer surrounding an endosome.
|
1 | Q5FVC7 (/IDA) |
|
Endosome membrane GO:0010008
The lipid bilayer surrounding an endosome.
|
1 | Q6ZQK5 (/ISO) |
|
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
1 | Q7KS50 (/ISS) |
