CATH Superfamily 2.30.29.30
Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
".
FunFam 23: Kinesin family member 1B
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 21 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
4 | F1M4A4 (/IPI) O60333 (/IPI) O88658 (/IPI) Q60575 (/IPI) |
Microtubule motor activity GO:0003777
Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP).
|
2 | O60333 (/ISS) O88658 (/ISS) |
Microtubule binding GO:0008017
Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers.
|
2 | F1M4A4 (/IDA) P33173 (/IDA) |
ATPase activity GO:0016887
Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.
|
2 | O88658 (/IDA) Q60575 (/IDA) |
ATPase activity GO:0016887
Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.
|
2 | O60333 (/ISS) O88658 (/ISS) |
Motor activity GO:0003774
Catalysis of the generation of force resulting either in movement along a microfilament or microtubule, or in torque resulting in membrane scission, coupled to the hydrolysis of a nucleoside triphosphate.
|
1 | Q12756 (/TAS) |
Microtubule motor activity GO:0003777
Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP).
|
1 | Q60575 (/IDA) |
Microtubule binding GO:0008017
Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers.
|
1 | P33173 (/ISO) |
Microtubule binding GO:0008017
Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers.
|
1 | Q60575 (/TAS) |
ATPase activity GO:0016887
Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.
|
1 | Q60575 (/ISO) |
Kinesin binding GO:0019894
Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation.
|
1 | O60333 (/TAS) |
Kinase binding GO:0019900
Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group.
|
1 | O88658 (/IPI) |
Kinase binding GO:0019900
Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group.
|
1 | Q60575 (/ISO) |
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
1 | Q12756 (/IPI) |
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
1 | P33173 (/ISO) |
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
1 | F1M4A4 (/IDA) |
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
1 | P33173 (/ISO) |
Scaffold protein binding GO:0097110
Interacting selectively and non-covalently with a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes.
|
1 | O88658 (/IPI) |
Scaffold protein binding GO:0097110
Interacting selectively and non-covalently with a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes.
|
1 | Q60575 (/ISO) |
ATP-dependent microtubule motor activity GO:1990939
Catalysis of movement along a microtubule, coupled to the hydrolysis of ATP.
|
1 | O88658 (/IDA) |
ATP-dependent microtubule motor activity GO:1990939
Catalysis of movement along a microtubule, coupled to the hydrolysis of ATP.
|
1 | Q60575 (/ISO) |
There are 42 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Intracellular mRNA localization GO:0008298
Any process in which mRNA is transported to, or maintained in, a specific location within the cell.
|
3 | C0LSN9 (/IMP) E9QDE5 (/IMP) F1QBV5 (/IMP) |
Myeloid cell differentiation GO:0030099
The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages.
|
3 | C0LSN9 (/IMP) E9QDE5 (/IMP) F1QBV5 (/IMP) |
Macrophage differentiation GO:0030225
The process in which a relatively unspecialized monocyte acquires the specialized features of a macrophage.
|
3 | C0LSN9 (/IMP) E9QDE5 (/IMP) F1QBV5 (/IMP) |
Axon extension GO:0048675
Long distance growth of a single axon process involved in cellular development.
|
3 | C0LSN9 (/IMP) E9QDE5 (/IMP) F1QBV5 (/IMP) |
Posterior lateral line ganglion development GO:0048917
The process whose specific outcome is the progression of the posterior lateral line ganglion over time, from its formation to the mature structure. The posterior lateral line ganglion develops from cranial ectodermal placodes situated behind the ear.
|
3 | C0LSN9 (/IMP) E9QDE5 (/IMP) F1QBV5 (/IMP) |
Posterior lateral line nerve development GO:0048918
The process whose specific outcome is the progression of the posterior lateral line nerve over time, from its formation to the mature structure. The posterior lateral line nerve innervates hair cells of the PLL and projects to an octavolateralis column in the hindbrain that consists of the medial octavolateralis nucleus (MON), the caudal octavolateralis nucleus, and the magnocellular nucleus.
|
3 | C0LSN9 (/IMP) E9QDE5 (/IMP) F1QBV5 (/IMP) |
Neuron projection maintenance GO:1990535
The organization process that preserves a neuron projection in a stable functional or structural state. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
|
3 | C0LSN9 (/IGI) E9QDE5 (/IGI) F1QBV5 (/IGI) |
Neuron projection maintenance GO:1990535
The organization process that preserves a neuron projection in a stable functional or structural state. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
|
3 | C0LSN9 (/IMP) E9QDE5 (/IMP) F1QBV5 (/IMP) |
Microtubule-based movement GO:0007018
A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules.
|
2 | O60333 (/ISS) O88658 (/ISS) |
Neuron-neuron synaptic transmission GO:0007270
The process of synaptic transmission from a neuron to another neuron across a synapse.
|
2 | O60333 (/ISS) O88658 (/ISS) |
Neuromuscular synaptic transmission GO:0007274
The process of synaptic transmission from a neuron to a muscle, across a synapse.
|
2 | O60333 (/ISS) O88658 (/ISS) |
Anterograde axonal transport GO:0008089
The directed movement of organelles or molecules along microtubules from the cell body toward the cell periphery in nerve cell axons.
|
2 | F1M4A4 (/IMP) Q60575 (/IMP) |
Anterograde axonal transport GO:0008089
The directed movement of organelles or molecules along microtubules from the cell body toward the cell periphery in nerve cell axons.
|
2 | O60333 (/ISS) O88658 (/ISS) |
Cytoskeleton-dependent intracellular transport GO:0030705
The directed movement of substances along cytoskeletal fibers such as microfilaments or microtubules within a cell.
|
2 | O60333 (/ISS) O88658 (/ISS) |
Anterograde neuronal dense core vesicle transport GO:1990048
The directed movement of substances in neuronal dense core vesicles along axonal microtubules towards the presynapse.
|
2 | F1M4A4 (/IGI) O88658 (/IGI) |
Anterograde neuronal dense core vesicle transport GO:1990048
The directed movement of substances in neuronal dense core vesicles along axonal microtubules towards the presynapse.
|
2 | P33173 (/ISO) Q60575 (/ISO) |
Retrograde neuronal dense core vesicle transport GO:1990049
The directed movement of neuronal dense core vesicles along axonal microtubules towards the cell body.
|
2 | F1M4A4 (/IGI) O88658 (/IGI) |
Retrograde neuronal dense core vesicle transport GO:1990049
The directed movement of neuronal dense core vesicles along axonal microtubules towards the cell body.
|
2 | P33173 (/ISO) Q60575 (/ISO) |
Microtubule-based movement GO:0007018
A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules.
|
1 | Q60575 (/IDA) |
Neuron-neuron synaptic transmission GO:0007270
The process of synaptic transmission from a neuron to another neuron across a synapse.
|
1 | Q60575 (/IMP) |
Neuromuscular synaptic transmission GO:0007274
The process of synaptic transmission from a neuron to a muscle, across a synapse.
|
1 | Q60575 (/IMP) |
Anterograde axonal transport GO:0008089
The directed movement of organelles or molecules along microtubules from the cell body toward the cell periphery in nerve cell axons.
|
1 | P33173 (/ISO) |
Anterograde axonal transport GO:0008089
The directed movement of organelles or molecules along microtubules from the cell body toward the cell periphery in nerve cell axons.
|
1 | Q12756 (/TAS) |
Embryo development ending in birth or egg hatching GO:0009792
The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell.
|
1 | Q60575 (/NAS) |
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
1 | O88658 (/IMP) |
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
1 | Q60575 (/ISO) |
Transport along microtubule GO:0010970
The movement of organelles or other particles from one location in the cell to another along microtubules, driven by motor activity.
|
1 | O88658 (/IDA) |
Transport along microtubule GO:0010970
The movement of organelles or other particles from one location in the cell to another along microtubules, driven by motor activity.
|
1 | Q60575 (/ISO) |
Interkinetic nuclear migration GO:0022027
The movement of the nucleus of the ventricular zone cell between the apical and the basal zone surfaces. Mitosis occurs when the nucleus is near the apical surface, that is, the lumen of the ventricle.
|
1 | F1M4A4 (/IMP) |
Interkinetic nuclear migration GO:0022027
The movement of the nucleus of the ventricular zone cell between the apical and the basal zone surfaces. Mitosis occurs when the nucleus is near the apical surface, that is, the lumen of the ventricle.
|
1 | P33173 (/ISO) |
Cytoskeleton-dependent intracellular transport GO:0030705
The directed movement of substances along cytoskeletal fibers such as microfilaments or microtubules within a cell.
|
1 | Q60575 (/IDA) |
Lysosome localization GO:0032418
Any process in which a lysosome is transported to, and/or maintained in, a specific location.
|
1 | O88658 (/IMP) |
Lysosome localization GO:0032418
Any process in which a lysosome is transported to, and/or maintained in, a specific location.
|
1 | Q60575 (/ISO) |
Mitochondrion transport along microtubule GO:0047497
The directed movement of a mitochondrion along a microtubule, mediated by motor proteins.
|
1 | Q60575 (/IDA) |
Protein transport along microtubule GO:0098840
The directed movement of a protein along a microtubule, mediated by motor proteins.
|
1 | F1M4A4 (/IDA) |
Protein transport along microtubule GO:0098840
The directed movement of a protein along a microtubule, mediated by motor proteins.
|
1 | P33173 (/ISO) |
Response to rotenone GO:1904647
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rotenone stimulus.
|
1 | O88658 (/IEP) |
Anterograde neuronal dense core vesicle transport GO:1990048
The directed movement of substances in neuronal dense core vesicles along axonal microtubules towards the presynapse.
|
1 | Q12756 (/ISS) |
Retrograde neuronal dense core vesicle transport GO:1990049
The directed movement of neuronal dense core vesicles along axonal microtubules towards the cell body.
|
1 | Q12756 (/ISS) |
Cellular response to nerve growth factor stimulus GO:1990090
A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nerve growth factor stimulus.
|
1 | O88658 (/IEP) |
Protein localization to cell periphery GO:1990778
A process in which a protein is transported to, or maintained in, the cell periphery.
|
1 | O88658 (/IMP) |
Protein localization to cell periphery GO:1990778
A process in which a protein is transported to, or maintained in, the cell periphery.
|
1 | Q60575 (/ISO) |
There are 33 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
2 | O88658 (/IDA) Q60575 (/IDA) |
Microtubule associated complex GO:0005875
Any multimeric complex connected to a microtubule.
|
2 | O60333 (/ISS) O88658 (/ISS) |
Cytoplasmic vesicle membrane GO:0030659
The lipid bilayer surrounding a cytoplasmic vesicle.
|
2 | O60333 (/ISS) O88658 (/ISS) |
Cytoplasmic vesicle GO:0031410
A vesicle found in the cytoplasm of a cell.
|
2 | O60333 (/ISS) Q60575 (/ISS) |
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
|
2 | O88658 (/IDA) P33173 (/IDA) |
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
|
2 | O60333 (/ISS) Q60575 (/ISS) |
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
|
2 | F1M4A4 (/IDA) P33173 (/IDA) |
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
1 | Q60575 (/HDA) |
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
1 | Q60575 (/ISO) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | F1M4A4 (/IDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | P33173 (/ISO) |
Microtubule GO:0005874
Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
|
1 | F1M4A4 (/IDA) |
Microtubule GO:0005874
Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
|
1 | P33173 (/ISO) |
Microtubule associated complex GO:0005875
Any multimeric complex connected to a microtubule.
|
1 | Q60575 (/IDA) |
Synaptic vesicle GO:0008021
A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
|
1 | F1M4A4 (/IDA) |
Synaptic vesicle GO:0008021
A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
|
1 | P33173 (/ISO) |
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
1 | O88658 (/IDA) |
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
1 | Q60575 (/ISO) |
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
|
1 | F1M4A4 (/IDA) |
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
|
1 | P33173 (/ISO) |
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
|
1 | F1M4A4 (/IDA) |
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
|
1 | P33173 (/ISO) |
Cytoplasmic vesicle membrane GO:0030659
The lipid bilayer surrounding a cytoplasmic vesicle.
|
1 | Q60575 (/IDA) |
Cytoplasmic vesicle GO:0031410
A vesicle found in the cytoplasm of a cell.
|
1 | O88658 (/IDA) |
Cytoplasmic vesicle GO:0031410
A vesicle found in the cytoplasm of a cell.
|
1 | Q60575 (/ISO) |
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
|
1 | F1M4A4 (/IDA) |
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
|
1 | P33173 (/ISO) |
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
|
1 | Q60575 (/ISO) |
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
|
1 | P33173 (/ISO) |
Presynapse GO:0098793
The part of a synapse that is part of the presynaptic cell.
|
1 | F1M4A4 (/IDA) |
Presynapse GO:0098793
The part of a synapse that is part of the presynaptic cell.
|
1 | P33173 (/ISO) |
Postsynapse GO:0098794
The part of a synapse that is part of the post-synaptic cell.
|
1 | F1M4A4 (/IDA) |
Postsynapse GO:0098794
The part of a synapse that is part of the post-synaptic cell.
|
1 | P33173 (/ISO) |