The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 221: Lysosomal trafficking regulator

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 1 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 Q99698 (/IPI)

There are 32 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Pigmentation GO:0043473
The accumulation of pigment in an organism, tissue or cell, either by increased deposition or by increased number of cells.
3 P97412 (/IMP) Q99698 (/IMP) Q9Z2X9 (/IMP)
Endosome to lysosome transport via multivesicular body sorting pathway GO:0032510
The directed movement of substances from endosomes to lysosomes by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the lysosome.
2 A5A776 (/ISS) Q9TTK4 (/ISS)
Natural killer cell mediated cytotoxicity GO:0042267
The directed killing of a target cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.
2 A5A776 (/ISS) Q9TTK4 (/ISS)
Pigmentation GO:0043473
The accumulation of pigment in an organism, tissue or cell, either by increased deposition or by increased number of cells.
2 A5A776 (/ISS) Q9TTK4 (/ISS)
Neutrophil mediated immunity GO:0002446
Any process involved in the carrying out of an immune response by a neutrophil.
1 P97412 (/IMP)
T cell mediated immunity GO:0002456
Any process involved in the carrying out of an immune response by a T cell.
1 P97412 (/IMP)
Phospholipid metabolic process GO:0006644
The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester.
1 P97412 (/IMP)
Microtubule-based process GO:0007017
Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins.
1 P97412 (/IMP)
Lysosome organization GO:0007040
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases.
1 P97412 (/IMP)
Blood coagulation GO:0007596
The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.
1 P97412 (/IMP)
Leukocyte chemotaxis GO:0030595
The movement of a leukocyte in response to an external stimulus.
1 P97412 (/IMP)
Leukocyte chemotaxis GO:0030595
The movement of a leukocyte in response to an external stimulus.
1 Q99698 (/ISS)
Melanosome organization GO:0032438
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a melanosome. A melanosome is a tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored.
1 P97412 (/IMP)
Melanosome organization GO:0032438
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a melanosome. A melanosome is a tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored.
1 Q99698 (/ISS)
Endosome to lysosome transport via multivesicular body sorting pathway GO:0032510
The directed movement of substances from endosomes to lysosomes by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the lysosome.
1 Q99698 (/IMP)
Endosome to lysosome transport via multivesicular body sorting pathway GO:0032510
The directed movement of substances from endosomes to lysosomes by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the lysosome.
1 P97412 (/ISO)
Positive regulation of natural killer cell activation GO:0032816
Any process that activates or increases the frequency, rate or extent of natural killer cell activation.
1 P97412 (/IMP)
Secretion of lysosomal enzymes GO:0033299
The controlled release of lysosomal enzymes by a cell.
1 P97412 (/IMP)
Mast cell secretory granule organization GO:0033364
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule in a mast cell. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion.
1 P97412 (/IMP)
Mast cell secretory granule organization GO:0033364
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule in a mast cell. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion.
1 Q99698 (/ISS)
Natural killer cell mediated cytotoxicity GO:0042267
The directed killing of a target cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.
1 Q99698 (/IMP)
Natural killer cell mediated cytotoxicity GO:0042267
The directed killing of a target cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.
1 P97412 (/ISO)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 P97412 (/IMP)
Defense response to bacterium GO:0042742
Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
1 P97412 (/IMP)
Defense response to bacterium GO:0042742
Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
1 Q99698 (/ISS)
Defense response to protozoan GO:0042832
Reactions triggered in response to the presence of a protozoan that act to protect the cell or organism.
1 P97412 (/IMP)
Defense response to protozoan GO:0042832
Reactions triggered in response to the presence of a protozoan that act to protect the cell or organism.
1 Q99698 (/ISS)
Pigmentation GO:0043473
The accumulation of pigment in an organism, tissue or cell, either by increased deposition or by increased number of cells.
1 P97412 (/ISO)
Pigment granule organization GO:0048753
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pigment granule.
1 P97412 (/IMP)
Defense response to virus GO:0051607
Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
1 P97412 (/IMP)
Defense response to virus GO:0051607
Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
1 Q99698 (/ISS)
Phospholipid homeostasis GO:0055091
Any process involved in the maintenance of an internal steady state of phospholipid within an organism or cell.
1 P97412 (/IMP)

There are 4 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Microtubule cytoskeleton GO:0015630
The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins.
2 A5A776 (/ISS) Q9TTK4 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P97412 (/IDA)
Microtubule cytoskeleton GO:0015630
The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins.
1 Q99698 (/IDA)
Microtubule cytoskeleton GO:0015630
The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins.
1 P97412 (/ISO)
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