The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 220: methylosome subunit pICln isoform X1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
11 P54105 (/HDA) P54105 (/HDA) P54105 (/HDA) P54105 (/HDA) P54105 (/HDA) P54105 (/HDA) P54105 (/HDA) P54105 (/HDA) P54105 (/HDA) P54105 (/HDA)
(1 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
11 P54105 (/IPI) P54105 (/IPI) P54105 (/IPI) P54105 (/IPI) P54105 (/IPI) P54105 (/IPI) P54105 (/IPI) P54105 (/IPI) P54105 (/IPI) P54105 (/IPI)
(1 more)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
11 P54105 (/IDA) P54105 (/IDA) P54105 (/IDA) P54105 (/IDA) P54105 (/IDA) P54105 (/IDA) P54105 (/IDA) P54105 (/IDA) P54105 (/IDA) P54105 (/IDA)
(1 more)
Intracellular calcium activated chloride channel activity GO:0005229
Enables the transmembrane transfer of chloride by a channel that opens in response to stimulus by a calcium ion or ions. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism.
1 P35521 (/IMP)
Potassium channel activity GO:0005267
Enables the facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
1 P35521 (/IMP)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
1 Q61189 (/ISO)
Splicing factor binding GO:1990935
Interacting selectively and non-covalently with any protein involved in the process of removing sections of the primary RNA transcript to form the mature form of the RNA.
1 P35521 (/IPI)

There are 12 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Spliceosomal snRNP assembly GO:0000387
The aggregation, arrangement and bonding together of one or more snRNA and multiple protein components to form a ribonucleoprotein complex that is involved in formation of the spliceosome.
11 P54105 (/IDA) P54105 (/IDA) P54105 (/IDA) P54105 (/IDA) P54105 (/IDA) P54105 (/IDA) P54105 (/IDA) P54105 (/IDA) P54105 (/IDA) P54105 (/IDA)
(1 more)
Spliceosomal snRNP assembly GO:0000387
The aggregation, arrangement and bonding together of one or more snRNA and multiple protein components to form a ribonucleoprotein complex that is involved in formation of the spliceosome.
11 P54105 (/TAS) P54105 (/TAS) P54105 (/TAS) P54105 (/TAS) P54105 (/TAS) P54105 (/TAS) P54105 (/TAS) P54105 (/TAS) P54105 (/TAS) P54105 (/TAS)
(1 more)
Spliceosomal snRNP assembly GO:0000387
The aggregation, arrangement and bonding together of one or more snRNA and multiple protein components to form a ribonucleoprotein complex that is involved in formation of the spliceosome.
7 P35521 (/ISS) P54106 (/ISS) P54106 (/ISS) Q04753 (/ISS) Q28678 (/ISS) Q5R719 (/ISS) Q61189 (/ISS)
Axon extension GO:0048675
Long distance growth of a single axon process involved in cellular development.
4 A0A0R4IJ12 (/IMP) P79725 (/IMP) Q6NY72 (/IMP) Q7ZTV8 (/IMP)
Spliceosomal snRNP assembly GO:0000387
The aggregation, arrangement and bonding together of one or more snRNA and multiple protein components to form a ribonucleoprotein complex that is involved in formation of the spliceosome.
1 Q61189 (/ISO)
Chloride transport GO:0006821
The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q04753 (/IDA)
Chloride transport GO:0006821
The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q61189 (/ISO)
Cell volume homeostasis GO:0006884
Any process involved in maintaining the steady state of a cell's volume. The cell's volume refers to the three-dimensional space occupied by a cell.
1 Q04753 (/IMP)
Cell volume homeostasis GO:0006884
Any process involved in maintaining the steady state of a cell's volume. The cell's volume refers to the three-dimensional space occupied by a cell.
1 Q61189 (/ISO)
Negative regulation of cell volume GO:0045794
Any process that decreases cell volume.
1 Q61189 (/IGI)
Potassium ion transmembrane transport GO:0071805
A process in which a potassium ion is transported from one side of a membrane to the other.
1 P35521 (/IMP)
Chloride transmembrane transport GO:1902476
The process in which chloride is transported across a membrane.
1 P35521 (/IMP)

There are 18 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
24 E9PJF4 (/IDA) E9PJF4 (/IDA) E9PJF4 (/IDA) E9PJF4 (/IDA) E9PJF4 (/IDA) E9PJF4 (/IDA) E9PJF4 (/IDA) E9PJF4 (/IDA) E9PJF4 (/IDA) E9PJF4 (/IDA)
(14 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
22 E9PJF4 (/IDA) E9PJF4 (/IDA) E9PJF4 (/IDA) E9PJF4 (/IDA) E9PJF4 (/IDA) E9PJF4 (/IDA) E9PJF4 (/IDA) E9PJF4 (/IDA) E9PJF4 (/IDA) E9PJF4 (/IDA)
(12 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
11 P54105 (/IDA) P54105 (/IDA) P54105 (/IDA) P54105 (/IDA) P54105 (/IDA) P54105 (/IDA) P54105 (/IDA) P54105 (/IDA) P54105 (/IDA) P54105 (/IDA)
(1 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
11 P54105 (/TAS) P54105 (/TAS) P54105 (/TAS) P54105 (/TAS) P54105 (/TAS) P54105 (/TAS) P54105 (/TAS) P54105 (/TAS) P54105 (/TAS) P54105 (/TAS)
(1 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
11 P54105 (/TAS) P54105 (/TAS) P54105 (/TAS) P54105 (/TAS) P54105 (/TAS) P54105 (/TAS) P54105 (/TAS) P54105 (/TAS) P54105 (/TAS) P54105 (/TAS)
(1 more)
Methylosome GO:0034709
A large (20 S) protein complex that possesses protein arginine methyltransferase activity and modifies specific arginines to dimethylarginines in the arginine- and glycine-rich domains of several spliceosomal Sm proteins, thereby targeting these proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein (snRNP) core particles. Proteins found in the methylosome include the methyltransferase JBP1 (PRMT5), pICln (CLNS1A), MEP50 (WDR77), and unmethylated forms of SM proteins that have RG domains.
11 P54105 (/IDA) P54105 (/IDA) P54105 (/IDA) P54105 (/IDA) P54105 (/IDA) P54105 (/IDA) P54105 (/IDA) P54105 (/IDA) P54105 (/IDA) P54105 (/IDA)
(1 more)
PICln-Sm protein complex GO:0034715
A protein complex that contains pICln (CLNS1A) and several Sm proteins, including SmD1, SmD2, SmE, SmF, and SmG.
11 P54105 (/IDA) P54105 (/IDA) P54105 (/IDA) P54105 (/IDA) P54105 (/IDA) P54105 (/IDA) P54105 (/IDA) P54105 (/IDA) P54105 (/IDA) P54105 (/IDA)
(1 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
7 P35521 (/ISS) P54106 (/ISS) P54106 (/ISS) Q04753 (/ISS) Q28678 (/ISS) Q5R719 (/ISS) Q61189 (/ISS)
Methylosome GO:0034709
A large (20 S) protein complex that possesses protein arginine methyltransferase activity and modifies specific arginines to dimethylarginines in the arginine- and glycine-rich domains of several spliceosomal Sm proteins, thereby targeting these proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein (snRNP) core particles. Proteins found in the methylosome include the methyltransferase JBP1 (PRMT5), pICln (CLNS1A), MEP50 (WDR77), and unmethylated forms of SM proteins that have RG domains.
7 P35521 (/ISS) P54106 (/ISS) P54106 (/ISS) Q04753 (/ISS) Q28678 (/ISS) Q5R719 (/ISS) Q61189 (/ISS)
PICln-Sm protein complex GO:0034715
A protein complex that contains pICln (CLNS1A) and several Sm proteins, including SmD1, SmD2, SmE, SmF, and SmG.
7 P35521 (/ISS) P54106 (/ISS) P54106 (/ISS) Q04753 (/ISS) Q28678 (/ISS) Q5R719 (/ISS) Q61189 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
6 P35521 (/ISS) P54106 (/ISS) P54106 (/ISS) Q28678 (/ISS) Q5R719 (/ISS) Q61189 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q61189 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q61189 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q61189 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 P35521 (/IDA)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
1 P35521 (/IDA)
Methylosome GO:0034709
A large (20 S) protein complex that possesses protein arginine methyltransferase activity and modifies specific arginines to dimethylarginines in the arginine- and glycine-rich domains of several spliceosomal Sm proteins, thereby targeting these proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein (snRNP) core particles. Proteins found in the methylosome include the methyltransferase JBP1 (PRMT5), pICln (CLNS1A), MEP50 (WDR77), and unmethylated forms of SM proteins that have RG domains.
1 Q61189 (/ISO)
PICln-Sm protein complex GO:0034715
A protein complex that contains pICln (CLNS1A) and several Sm proteins, including SmD1, SmD2, SmE, SmF, and SmG.
1 Q61189 (/ISO)
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