The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 160: DCC-interacting protein 13-beta isoform X2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 13 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
5 B2XCM0 (/IPI) F1RB27 (/IPI) Q8K3G9 (/IPI) Q8K3G9 (/IPI) Q8NEU8 (/IPI)
Phosphatidylserine binding GO:0001786
Interacting selectively and non-covalently with phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine.
2 Q8K3G9 (/ISO) Q8K3G9 (/ISO)
Phosphatidylserine binding GO:0001786
Interacting selectively and non-covalently with phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine.
2 Q8K3G9 (/ISS) Q8K3G9 (/ISS)
Rab GTPase binding GO:0017137
Interacting selectively and non-covalently with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases.
2 Q8K3G9 (/ISO) Q8K3G9 (/ISO)
Phosphatidylinositol binding GO:0035091
Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives.
2 Q8K3G9 (/ISO) Q8K3G9 (/ISO)
Phosphatidylinositol binding GO:0035091
Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives.
2 Q8K3G9 (/ISS) Q8K3G9 (/ISS)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
2 Q8K3G9 (/ISO) Q8K3G9 (/ISO)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
2 Q8K3G9 (/ISS) Q8K3G9 (/ISS)
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
2 Q8K3G9 (/ISO) Q8K3G9 (/ISO)
Phosphatidylserine binding GO:0001786
Interacting selectively and non-covalently with phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine.
1 Q8NEU8 (/IDA)
Phosphatidylinositol binding GO:0035091
Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives.
1 Q8NEU8 (/IDA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 Q8NEU8 (/IDA)
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
1 Q8NEU8 (/IPI)

There are 51 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of glucose import GO:0046325
Any process that stops, prevents, or reduces the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle.
4 B4F779 (/ISS) Q8K3G9 (/ISS) Q8K3G9 (/ISS) Q8NEU8 (/ISS)
Glucose homeostasis GO:0042593
Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.
3 B4F779 (/ISS) Q8K3G9 (/ISS) Q8K3G9 (/ISS)
Negative regulation of glucose import GO:0046325
Any process that stops, prevents, or reduces the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle.
3 Q8K3G9 (/IMP) Q8K3G9 (/IMP) Q8NEU8 (/IMP)
Diet induced thermogenesis GO:0002024
The process that results in increased metabolic rate in tissues of an organism. It is triggered by the detection of dietary excess. This process is achieved via signalling in the sympathetic nervous system.
2 Q8K3G9 (/IMP) Q8K3G9 (/IMP)
Protein import into nucleus GO:0006606
The directed movement of a protein from the cytoplasm to the nucleus.
2 Q8K3G9 (/ISO) Q8K3G9 (/ISO)
Protein import into nucleus GO:0006606
The directed movement of a protein from the cytoplasm to the nucleus.
2 Q8K3G9 (/ISS) Q8K3G9 (/ISS)
Transforming growth factor beta receptor signaling pathway GO:0007179
A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2 Q8K3G9 (/ISO) Q8K3G9 (/ISO)
Transforming growth factor beta receptor signaling pathway GO:0007179
A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2 Q8K3G9 (/ISS) Q8K3G9 (/ISS)
Cell population proliferation GO:0008283
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
2 Q8K3G9 (/ISO) Q8K3G9 (/ISO)
Cell population proliferation GO:0008283
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
2 Q8K3G9 (/ISS) Q8K3G9 (/ISS)
Cold acclimation GO:0009631
Any process that increases freezing tolerance of an organism in response to low, nonfreezing temperatures.
2 Q8K3G9 (/IMP) Q8K3G9 (/IMP)
Regulation of fibroblast migration GO:0010762
Any process that modulates the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium.
2 Q8K3G9 (/IMP) Q8K3G9 (/IMP)
Adiponectin-activated signaling pathway GO:0033211
A series of molecular signals initiated by the binding of adiponectin to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2 Q8K3G9 (/IMP) Q8K3G9 (/IMP)
Regulation of toll-like receptor 4 signaling pathway GO:0034143
Any process that modulates the frequency, rate, or extent of toll-like receptor 4 signaling pathway.
2 Q8K3G9 (/IMP) Q8K3G9 (/IMP)
Cellular response to hepatocyte growth factor stimulus GO:0035729
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hepatocyte growth factor stimulus.
2 Q8K3G9 (/IMP) Q8K3G9 (/IMP)
Glucose homeostasis GO:0042593
Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.
2 Q8K3G9 (/ISO) Q8K3G9 (/ISO)
Regulation of innate immune response GO:0045088
Any process that modulates the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection.
2 Q8K3G9 (/IMP) Q8K3G9 (/IMP)
Negative regulation of fatty acid oxidation GO:0046322
Any process that stops, prevents, or reduces the frequency, rate or extent of fatty acid oxidation.
2 Q8K3G9 (/IMP) Q8K3G9 (/IMP)
Negative regulation of glucose import GO:0046325
Any process that stops, prevents, or reduces the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle.
2 Q8K3G9 (/ISO) Q8K3G9 (/ISO)
Negative regulation of neurogenesis GO:0050768
Any process that stops, prevents, or reduces the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system.
2 Q8K3G9 (/IMP) Q8K3G9 (/IMP)
Protein homotetramerization GO:0051289
The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.
2 Q8K3G9 (/ISO) Q8K3G9 (/ISO)
Protein homotetramerization GO:0051289
The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.
2 Q8K3G9 (/ISS) Q8K3G9 (/ISS)
Positive regulation of phagocytosis, engulfment GO:0060100
Any process that activates or increases the frequency, rate or extent of the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis.
2 Q8K3G9 (/IMP) Q8K3G9 (/IMP)
Positive regulation of cold-induced thermogenesis GO:0120162
Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis.
2 Q8K3G9 (/IMP) Q8K3G9 (/IMP)
Negative regulation of cytokine production involved in inflammatory response GO:1900016
Any process that stops, prevents or reduces the frequency, rate or extent of cytokine production involved in inflammatory response.
2 Q8K3G9 (/IMP) Q8K3G9 (/IMP)
Negative regulation of cellular response to insulin stimulus GO:1900077
Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to insulin stimulus.
2 Q8K3G9 (/IMP) Q8K3G9 (/IMP)
Positive regulation of macropinocytosis GO:1905303
Any process that activates or increases the frequency, rate or extent of macropinocytosis.
2 Q8K3G9 (/IMP) Q8K3G9 (/IMP)
Positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis GO:1905451
Any process that activates or increases the frequency, rate or extent of Fc-gamma receptor signaling pathway involved in phagocytosis.
2 Q8K3G9 (/IMP) Q8K3G9 (/IMP)
Negative regulation of neural precursor cell proliferation GO:2000178
Any process that stops, prevents, or reduces the frequency, rate or extent of neural precursor cell proliferation.
2 Q8K3G9 (/IMP) Q8K3G9 (/IMP)
Diet induced thermogenesis GO:0002024
The process that results in increased metabolic rate in tissues of an organism. It is triggered by the detection of dietary excess. This process is achieved via signalling in the sympathetic nervous system.
1 Q8NEU8 (/ISS)
Protein import into nucleus GO:0006606
The directed movement of a protein from the cytoplasm to the nucleus.
1 Q8NEU8 (/IDA)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
1 Q8NEU8 (/TAS)
Transforming growth factor beta receptor signaling pathway GO:0007179
A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 Q8NEU8 (/IMP)
Cell population proliferation GO:0008283
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
1 Q8NEU8 (/IDA)
Cold acclimation GO:0009631
Any process that increases freezing tolerance of an organism in response to low, nonfreezing temperatures.
1 Q8NEU8 (/ISS)
Regulation of fibroblast migration GO:0010762
Any process that modulates the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium.
1 Q8NEU8 (/ISS)
Adiponectin-activated signaling pathway GO:0033211
A series of molecular signals initiated by the binding of adiponectin to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 Q8NEU8 (/ISS)
Regulation of toll-like receptor 4 signaling pathway GO:0034143
Any process that modulates the frequency, rate, or extent of toll-like receptor 4 signaling pathway.
1 Q8NEU8 (/ISS)
Cellular response to hepatocyte growth factor stimulus GO:0035729
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hepatocyte growth factor stimulus.
1 Q8NEU8 (/ISS)
Glucose homeostasis GO:0042593
Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.
1 Q8NEU8 (/IMP)
Regulation of innate immune response GO:0045088
Any process that modulates the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection.
1 Q8NEU8 (/ISS)
Negative regulation of fatty acid oxidation GO:0046322
Any process that stops, prevents, or reduces the frequency, rate or extent of fatty acid oxidation.
1 Q8NEU8 (/ISS)
Negative regulation of neurogenesis GO:0050768
Any process that stops, prevents, or reduces the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system.
1 Q8NEU8 (/ISS)
Protein homotetramerization GO:0051289
The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.
1 Q8NEU8 (/IDA)
Positive regulation of phagocytosis, engulfment GO:0060100
Any process that activates or increases the frequency, rate or extent of the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis.
1 Q8NEU8 (/ISS)
Positive regulation of cold-induced thermogenesis GO:0120162
Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis.
1 Q8NEU8 (/ISS)
Negative regulation of cytokine production involved in inflammatory response GO:1900016
Any process that stops, prevents or reduces the frequency, rate or extent of cytokine production involved in inflammatory response.
1 Q8NEU8 (/ISS)
Negative regulation of cellular response to insulin stimulus GO:1900077
Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to insulin stimulus.
1 Q8NEU8 (/ISS)
Positive regulation of macropinocytosis GO:1905303
Any process that activates or increases the frequency, rate or extent of macropinocytosis.
1 Q8NEU8 (/ISS)
Positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis GO:1905451
Any process that activates or increases the frequency, rate or extent of Fc-gamma receptor signaling pathway involved in phagocytosis.
1 Q8NEU8 (/ISS)
Negative regulation of neural precursor cell proliferation GO:2000178
Any process that stops, prevents, or reduces the frequency, rate or extent of neural precursor cell proliferation.
1 Q8NEU8 (/ISS)

There are 33 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 Q8K3G9 (/IDA) Q8K3G9 (/IDA) Q8NEU8 (/IDA)
Ruffle GO:0001726
Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork.
2 Q8K3G9 (/IDA) Q8K3G9 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 Q8K3G9 (/ISO) Q8K3G9 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 Q8K3G9 (/ISS) Q8K3G9 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q8K3G9 (/IDA) Q8K3G9 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q8K3G9 (/ISO) Q8K3G9 (/ISO)
Endosome GO:0005768
A vacuole to which materials ingested by endocytosis are delivered.
2 B2XCM0 (/IGI) F1RB27 (/IGI)
Endosome GO:0005768
A vacuole to which materials ingested by endocytosis are delivered.
2 Q8K3G9 (/ISO) Q8K3G9 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 Q8K3G9 (/ISO) Q8K3G9 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 Q8K3G9 (/ISS) Q8K3G9 (/ISS)
Endosome membrane GO:0010008
The lipid bilayer surrounding an endosome.
2 Q8K3G9 (/ISO) Q8K3G9 (/ISO)
Endosome membrane GO:0010008
The lipid bilayer surrounding an endosome.
2 Q8K3G9 (/ISS) Q8K3G9 (/ISS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 Q8K3G9 (/ISO) Q8K3G9 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 Q8K3G9 (/ISS) Q8K3G9 (/ISS)
Cytoplasmic vesicle GO:0031410
A vesicle found in the cytoplasm of a cell.
2 Q8K3G9 (/ISO) Q8K3G9 (/ISO)
Cytoplasmic vesicle GO:0031410
A vesicle found in the cytoplasm of a cell.
2 Q8K3G9 (/ISS) Q8K3G9 (/ISS)
Vesicle GO:0031982
Any small, fluid-filled, spherical organelle enclosed by membrane.
2 Q8K3G9 (/ISO) Q8K3G9 (/ISO)
Early phagosome GO:0032009
A membrane-bounded intracellular vesicle as initially formed upon the ingestion of particulate material by phagocytosis.
2 Q8K3G9 (/IDA) Q8K3G9 (/IDA)
Ruffle membrane GO:0032587
The portion of the plasma membrane surrounding a ruffle.
2 Q8K3G9 (/IDA) Q8K3G9 (/IDA)
Early phagosome membrane GO:0036186
The lipid bilayer surrounding an early phagosome.
2 Q8K3G9 (/IDA) Q8K3G9 (/IDA)
Macropinosome GO:0044354
A membrane-bounded, uncoated intracellular vesicle formed by the process of macropinocytosis.
2 Q8K3G9 (/IDA) Q8K3G9 (/IDA)
Ruffle GO:0001726
Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork.
1 Q8NEU8 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q8NEU8 (/IDA)
Endosome GO:0005768
A vacuole to which materials ingested by endocytosis are delivered.
1 Q8NEU8 (/IDA)
Endosome membrane GO:0010008
The lipid bilayer surrounding an endosome.
1 Q8NEU8 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q8NEU8 (/IDA)
Cytoplasmic vesicle GO:0031410
A vesicle found in the cytoplasm of a cell.
1 Q8NEU8 (/IDA)
Vesicle GO:0031982
Any small, fluid-filled, spherical organelle enclosed by membrane.
1 Q8NEU8 (/IDA)
Early phagosome GO:0032009
A membrane-bounded intracellular vesicle as initially formed upon the ingestion of particulate material by phagocytosis.
1 Q8NEU8 (/ISS)
Ruffle membrane GO:0032587
The portion of the plasma membrane surrounding a ruffle.
1 Q8NEU8 (/ISS)
Early phagosome membrane GO:0036186
The lipid bilayer surrounding an early phagosome.
1 Q8NEU8 (/ISS)
Macropinosome GO:0044354
A membrane-bounded, uncoated intracellular vesicle formed by the process of macropinocytosis.
1 Q8NEU8 (/ISS)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 Q8NEU8 (/HDA)