CATH Superfamily 2.30.29.30
Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
".
FunFam 133: myosin phosphatase Rho-interacting protein isoform...
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 8 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
1 | Q6WCQ1 (/IPI) |
|
GTP-Rho binding GO:0017049
Interacting selectively and non-covalently with the GTP-bound form of the Rho protein.
|
1 | Q9H2D6 (/NAS) |
|
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
|
1 | Q9H2D6 (/IPI) |
|
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
|
1 | Q99KW3 (/ISO) |
|
Myosin II binding GO:0045159
Interacting selectively and non-covalently with a class II myosin, any member of the class of 'conventional' double-headed myosins that includes muscle myosin.
|
1 | Q9H2D6 (/NAS) |
|
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
|
1 | Q6WCQ1 (/HDA) |
|
Actin filament binding GO:0051015
Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
|
1 | Q9H2D6 (/IDA) |
|
Actin filament binding GO:0051015
Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
|
1 | Q99KW3 (/ISO) |
There are 12 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Positive regulation of substrate adhesion-dependent cell spreading GO:1900026
Any process that activates or increases the frequency, rate or extent of substrate adhesion-dependent cell spreading.
|
2 | Q99KW3 (/IDA) Q9H2D6 (/IDA) |
|
Positive regulation of protein phosphorylation GO:0001934
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
|
1 | Q9ERE6 (/IMP) |
|
Positive regulation of protein phosphorylation GO:0001934
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
|
1 | P97434 (/ISO) |
|
Sensory perception of sound GO:0007605
The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound.
|
1 | Q99KW3 (/IMP) |
|
Actin modification GO:0030047
Covalent modification of an actin molecule.
|
1 | Q9H2D6 (/NAS) |
|
Maintenance of protein location in cell GO:0032507
Any process in which a protein is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere.
|
1 | Q9ERE6 (/IMP) |
|
Maintenance of protein location in cell GO:0032507
Any process in which a protein is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere.
|
1 | P97434 (/ISO) |
|
Negative regulation of myosin-light-chain-phosphatase activity GO:0035509
Any process that stops, prevents, or reduces the frequency, rate or extent of myosin-light-chain-phosphatase activity.
|
1 | Q9ERE6 (/IMP) |
|
Negative regulation of myosin-light-chain-phosphatase activity GO:0035509
Any process that stops, prevents, or reduces the frequency, rate or extent of myosin-light-chain-phosphatase activity.
|
1 | P97434 (/ISO) |
|
Barbed-end actin filament capping GO:0051016
The binding of a protein or protein complex to the barbed (or plus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits.
|
1 | Q9H2D6 (/NAS) |
|
Auditory receptor cell stereocilium organization GO:0060088
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a stereocilium. A stereocilium is an actin-based protrusion from the apical surface of auditory hair cells.
|
1 | Q99KW3 (/IMP) |
|
Positive regulation of substrate adhesion-dependent cell spreading GO:1900026
Any process that activates or increases the frequency, rate or extent of substrate adhesion-dependent cell spreading.
|
1 | Q99KW3 (/ISO) |
There are 8 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Actin cytoskeleton GO:0015629
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
|
3 | J3KSW8 (/IDA) Q6WCQ1 (/IDA) Q9H2D6 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | J3KSW8 (/IDA) Q6WCQ1 (/IDA) |
|
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
|
2 | Q6WCQ1 (/HDA) Q9H2D6 (/HDA) |
|
Actin cytoskeleton GO:0015629
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
|
2 | P97434 (/ISO) Q99KW3 (/ISO) |
|
Stress fiber GO:0001725
A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber.
|
1 | Q9ERE6 (/IDA) |
|
Stress fiber GO:0001725
A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber.
|
1 | P97434 (/ISO) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | P97434 (/ISO) |
|
Actin cytoskeleton GO:0015629
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
|
1 | Q9H2D6 (/NAS) |
