A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).

Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.

Any process that modulates the rate of GTP hydrolysis by a GTPase.

The series of molecular signals generated as a consequence of an ephrin receptor binding to an ephrin.

Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction.

Any process that decreases the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.

The change in form (cell shape and size) that occurs during the differentiation of an endothelial cell.

Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

Any process that modulates the rate of GTP hydrolysis by a GTPase.

The series of molecular signals generated as a consequence of an ephrin receptor binding to an ephrin.

The series of molecular signals generated as a consequence of an ephrin receptor binding to an ephrin.

The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).

The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).

The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).

Any process that decreases the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.

Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP.

Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP.

Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP.

Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP.

The aggregation, arrangement and bonding together of a set of components to form a ruffle, a projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork. The formation of ruffles (also called membrane ruffling) is thought to be controlled by a group of enzymes known as Rho GTPases, specifically RhoA, Rac1 and cdc42.

A cellular process that results in the controlled breakdown of synapse. After it starts the process is continuous until the synapse has disappeared.

A cellular process that results in the controlled breakdown of synapse. After it starts the process is continuous until the synapse has disappeared.

Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane.

Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane.

Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane.

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

A synapse that uses glutamate as a neurotransmitter.

A synapse that uses glutamate as a neurotransmitter.