The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 124: carboxyl-terminal PDZ ligand of neuronal nitric ox...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 11 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
9 O54960 (/IPI) O75052 (/IPI) O75052 (/IPI) O75052 (/IPI) O75052 (/IPI) O75052 (/IPI) O75052 (/IPI) O75052 (/IPI) Q8STF6 (/IPI)
Nitric-oxide synthase binding GO:0050998
Interacting selectively and non-covalently with the enzyme nitric-oxide synthase.
7 O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS)
Nitric-oxide synthase binding GO:0050998
Interacting selectively and non-covalently with the enzyme nitric-oxide synthase.
2 O54960 (/IPI) Q9D3A8 (/IPI)
Protease binding GO:0002020
Interacting selectively and non-covalently with any protease or peptidase.
1 O54960 (/IPI)
Protease binding GO:0002020
Interacting selectively and non-covalently with any protease or peptidase.
1 Q9D3A8 (/ISO)
Structural constituent of muscle GO:0008307
The action of a molecule that contributes to the structural integrity of a muscle fiber.
1 Q8STF6 (/IDA)
PDZ domain binding GO:0030165
Interacting selectively and non-covalently with a PDZ domain of a protein, a domain found in diverse signaling proteins.
1 O54960 (/IDA)
PDZ domain binding GO:0030165
Interacting selectively and non-covalently with a PDZ domain of a protein, a domain found in diverse signaling proteins.
1 Q9D3A8 (/ISO)
Nitric-oxide synthase regulator activity GO:0030235
Modulates the activity of nitric oxide synthase.
1 Q8STF6 (/NAS)
Nitric-oxide synthase binding GO:0050998
Interacting selectively and non-covalently with the enzyme nitric-oxide synthase.
1 O54960 (/IDA)
Nitric-oxide synthase binding GO:0050998
Interacting selectively and non-covalently with the enzyme nitric-oxide synthase.
1 Q9D3A8 (/ISO)

There are 38 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of heart rate by chemical signal GO:0003062
The regulation of the rate of heart contraction mediated by chemical signaling, hormonal, autocrine or paracrine.
7 O75052 (/IMP) O75052 (/IMP) O75052 (/IMP) O75052 (/IMP) O75052 (/IMP) O75052 (/IMP) O75052 (/IMP)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
7 O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS)
Positive regulation of nitric oxide mediated signal transduction GO:0010750
Any process that increases the rate, frequency or extent of nitric oxide mediated signal transduction. Nitric oxide mediated signal transduction is a series of molecular signals mediated by the detection of nitric oxide (NO).
7 O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS)
Regulation of nitric oxide biosynthetic process GO:0045428
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.
7 O75052 (/NAS) O75052 (/NAS) O75052 (/NAS) O75052 (/NAS) O75052 (/NAS) O75052 (/NAS) O75052 (/NAS)
Positive regulation of nitric oxide biosynthetic process GO:0045429
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.
7 O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS)
Regulation of nitric-oxide synthase activity GO:0050999
Any process that modulates the activity of the enzyme nitric-oxide synthase.
7 O75052 (/NAS) O75052 (/NAS) O75052 (/NAS) O75052 (/NAS) O75052 (/NAS) O75052 (/NAS) O75052 (/NAS)
Positive regulation of nitric-oxide synthase activity GO:0051000
Any process that activates or increases the activity of the enzyme nitric-oxide synthase.
7 O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS)
Regulation of ventricular cardiac muscle cell membrane repolarization GO:0060307
Any process that modulates the establishment or extent of a membrane potential in the polarizing direction towards the resting potential in a ventricular cardiomyocyte.
7 O75052 (/IMP) O75052 (/IMP) O75052 (/IMP) O75052 (/IMP) O75052 (/IMP) O75052 (/IMP) O75052 (/IMP)
Regulation of ventricular cardiac muscle cell membrane repolarization GO:0060307
Any process that modulates the establishment or extent of a membrane potential in the polarizing direction towards the resting potential in a ventricular cardiomyocyte.
7 O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS)
Regulation of cardiac muscle cell action potential GO:0098901
Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a cardiac muscle cell. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.
7 O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS)
Regulation of cardiac muscle cell action potential GO:0098901
Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a cardiac muscle cell. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.
7 O75052 (/TAS) O75052 (/TAS) O75052 (/TAS) O75052 (/TAS) O75052 (/TAS) O75052 (/TAS) O75052 (/TAS)
Postsynaptic actin cytoskeleton organization GO:0098974
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the postsynaptic actin cytoskeleton.
7 O75052 (/IDA) O75052 (/IDA) O75052 (/IDA) O75052 (/IDA) O75052 (/IDA) O75052 (/IDA) O75052 (/IDA)
Postsynaptic actin cytoskeleton organization GO:0098974
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the postsynaptic actin cytoskeleton.
7 O75052 (/IMP) O75052 (/IMP) O75052 (/IMP) O75052 (/IMP) O75052 (/IMP) O75052 (/IMP) O75052 (/IMP)
Positive regulation of potassium ion transmembrane transport GO:1901381
Any process that activates or increases the frequency, rate or extent of potassium ion transmembrane transport.
7 O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS)
Regulation of high voltage-gated calcium channel activity GO:1901841
Any process that modulates the frequency, rate or extent of high voltage-gated calcium channel activity.
7 O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS)
Positive regulation of delayed rectifier potassium channel activity GO:1902261
Any process that activates or increases the frequency, rate or extent of delayed rectifier potassium channel activity.
7 O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS)
Regulation of calcium ion transmembrane transport via high voltage-gated calcium channel GO:1902514
Any process that modulates the frequency, rate or extent of generation of calcium ion transmembrane transport via high voltage-gated calcium channel.
7 O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS)
Regulation of calcium ion transmembrane transport via high voltage-gated calcium channel GO:1902514
Any process that modulates the frequency, rate or extent of generation of calcium ion transmembrane transport via high voltage-gated calcium channel.
7 O75052 (/TAS) O75052 (/TAS) O75052 (/TAS) O75052 (/TAS) O75052 (/TAS) O75052 (/TAS) O75052 (/TAS)
Positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization GO:1903762
Any process that activates or increases the frequency, rate or extent of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization.
7 O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS)
Positive regulation of peptidyl-cysteine S-nitrosylation GO:2000170
Any process that activates or increases the frequency, rate or extent of peptidyl-cysteine S-nitrosylation.
7 O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS)
Neurotransmitter secretion GO:0007269
The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium-regulated exocytosis during synaptic transmission.
1 O54960 (/NAS)
Locomotory behavior GO:0007626
The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.
1 Q8STF6 (/IMP)
Neuron projection regeneration GO:0031102
The regrowth of neuronal processes such as axons or dendrites in response to their loss or damage.
1 O54960 (/IEP)
Positive regulation of locomotion GO:0040017
Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism.
1 Q8STF6 (/IMP)
Sarcomere organization GO:0045214
The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
1 Q8STF6 (/IGI)
Regulation of nitric oxide biosynthetic process GO:0045428
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.
1 O54960 (/TAS)
Regulation of oviposition GO:0046662
Any process that modulates the frequency, rate or extent of the deposition of eggs, either fertilized or not, upon a surface or into a medium.
1 Q8STF6 (/IMP)
Muscle cell cellular homeostasis GO:0046716
The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state.
1 Q8STF6 (/IMP)
Regulation of nitric-oxide synthase activity GO:0050999
Any process that modulates the activity of the enzyme nitric-oxide synthase.
1 O54960 (/IC)
Regulation of nitric-oxide synthase activity GO:0050999
Any process that modulates the activity of the enzyme nitric-oxide synthase.
1 O54960 (/TAS)
Regulation of cardiac muscle cell action potential GO:0098901
Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a cardiac muscle cell. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.
1 O54960 (/IC)
Negative regulation of neuron death GO:1901215
Any process that stops, prevents or reduces the frequency, rate or extent of neuron death.
1 O54960 (/IMP)
Negative regulation of neuron death GO:1901215
Any process that stops, prevents or reduces the frequency, rate or extent of neuron death.
1 Q9D3A8 (/ISO)
Regulation of high voltage-gated calcium channel activity GO:1901841
Any process that modulates the frequency, rate or extent of high voltage-gated calcium channel activity.
1 O54960 (/IDA)
Regulation of high voltage-gated calcium channel activity GO:1901841
Any process that modulates the frequency, rate or extent of high voltage-gated calcium channel activity.
1 Q9D3A8 (/ISO)
Regulation of calcium ion transmembrane transport via high voltage-gated calcium channel GO:1902514
Any process that modulates the frequency, rate or extent of generation of calcium ion transmembrane transport via high voltage-gated calcium channel.
1 O54960 (/IC)
Positive regulation of peptidyl-cysteine S-nitrosylation GO:2000170
Any process that activates or increases the frequency, rate or extent of peptidyl-cysteine S-nitrosylation.
1 O54960 (/IMP)
Positive regulation of peptidyl-cysteine S-nitrosylation GO:2000170
Any process that activates or increases the frequency, rate or extent of peptidyl-cysteine S-nitrosylation.
1 Q9D3A8 (/ISO)

There are 29 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
8 O54960 (/IDA) O75052 (/IDA) O75052 (/IDA) O75052 (/IDA) O75052 (/IDA) O75052 (/IDA) O75052 (/IDA) O75052 (/IDA)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
8 O54960 (/IMP) O75052 (/IMP) O75052 (/IMP) O75052 (/IMP) O75052 (/IMP) O75052 (/IMP) O75052 (/IMP) O75052 (/IMP)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
7 O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
7 O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
7 O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS)
Z disc GO:0030018
Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.
7 O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS)
Sarcoplasmic reticulum membrane GO:0033017
The lipid bilayer surrounding the sarcoplasmic reticulum.
7 O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS)
Sarcolemma GO:0042383
The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers.
7 O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
7 O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS) O75052 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 O54960 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q9D3A8 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 O54960 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q9D3A8 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 O54960 (/NAS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q9D3A8 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 O54960 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q9D3A8 (/ISO)
Dystrophin-associated glycoprotein complex GO:0016010
A multiprotein complex that forms a strong mechanical link between the cytoskeleton and extracellular matrix; typical of, but not confined to, muscle cells. The complex is composed of transmembrane, cytoplasmic, and extracellular proteins, including dystrophin, sarcoglycans, dystroglycan, dystrobrevins, syntrophins, sarcospan, caveolin-3, and NO synthase.
1 Q8STF6 (/IGI)
Z disc GO:0030018
Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.
1 Q9D3A8 (/IDA)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
1 Q8STF6 (/IDA)
Sarcoplasmic reticulum membrane GO:0033017
The lipid bilayer surrounding the sarcoplasmic reticulum.
1 Q9D3A8 (/IDA)
Striated muscle dense body GO:0055120
A vinculin-containing myofibril attachment structure of striated muscle that connects sarcomeres to the extracellular matrix. In nematode body wall muscle, the dense body performs the dual role of Z-disk and costamere.
1 Q8STF6 (/IDA)
Presynapse GO:0098793
The part of a synapse that is part of the presynaptic cell.
1 O54960 (/IDA)
Presynapse GO:0098793
The part of a synapse that is part of the presynaptic cell.
1 O54960 (/IMP)
Presynapse GO:0098793
The part of a synapse that is part of the presynaptic cell.
1 Q9D3A8 (/ISO)
Postsynapse GO:0098794
The part of a synapse that is part of the post-synaptic cell.
1 O54960 (/IDA)
Postsynapse GO:0098794
The part of a synapse that is part of the post-synaptic cell.
1 O54960 (/IMP)
Postsynapse GO:0098794
The part of a synapse that is part of the post-synaptic cell.
1 Q9D3A8 (/ISO)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
1 Q9D3A8 (/ISO)
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