The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Zn-binding ribosomal proteins
".
2.20.25.100
superfamily
Functional Families
Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
Superfamily: Ribosomal protein S27
This superfamily includes the a zinc-binding domain found in the ribosomal protein S27 from the small (30S) subunit of the ribosome. Structurally it is a beta-sandwich, composed of two three-stranded sheets. The human S27 has an N-terminal extension relative to the archaeal S27. This a novel fold due to the uniqueness of the strands arrangement. Highly conserved residues forming a hydrophobic patch are supposed to have a functional importance. S27 is involved in rRNa processing, direct binding to mRNA and degradation of damaged mRNAs. S27 is a C4 zinc finger protein of the CX2CX14-16CX2C class. Zinc finger motifs in ribosomal proteins mediate protein-RNA interactions, however it has been suggested the zinc finger in S27 possibly has no functional importance for modern S27 proteins, and is rather a fossil from ancient evolution. This view is supported by the sequence alignment, showing that the zinc finger motif is not strictly conserved.
GO Diversity
Unique GO annotations
42 Unique GO terms
EC Diversity
Unique EC annotations
0 Unique EC terms
Species Diversity
Unique species annotations
2192 Unique species
Sequence/Structure Diversity
Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.
Superfamily Summary
A general summary of information for this superfamily.
| Structures | |
|---|---|
| Domains: | 68 |
| Domain clusters (>95% seq id): | 9 |
| Domain clusters (>35% seq id): | 3 |
| Unique PDBs: | 68 |
| Alignments | |
| Structural Clusters (5A): | 1 |
| Structural Clusters (9A): | 1 |
| FunFam Clusters: | 8 |
| Function | |
| Unique EC: | |
| Unique GO: | 42 |
| Taxonomy | |
| Unique Species: | 2192 |